The sections in this article are:
Historical Background
Renin
Aldosterone
A Coordinated Renal‐Adrenal Hormonal System: Renin, Angiotensin, and Aldosterone
Comparative Aspects
Brief Overview of the Renin‐Angiotensin‐Aldosterone System
Biochemistry and Molecular Biology of the Renin System
Prorenin
Renin
Renin Substrate
Angiotensins I and
II
Angiotensin‐Converting Enzyme
Aldosterone
Methods of Measurement
Physiology
Prorenin
Renin
Renin Substrate
Angiotensin
II
Aldosterone
Cybernetics of the System
Coordinated Regulation of Sodium, Potassium, and Blood Pressure
Use of the Renin System to Understand Blood Pressure Control and Disorders of Pressure‐Volume Homeostasis
Two Forms of Vasoconstriction: Vasoconstriction‐Volume Analysis
Three Basic Tenets Concerning Plasma Renin Measurements
The Sodium—Calcium Connection
Dynamic Reciprocity of Two Forms of Vasoconstriction
The Sympathetic Nervous System and Modulation of the Two Forms of Arteriolar Vasoconstriction
Human Disorders of the Renin System
Hypertensive Disorders
Renin System Abnormalities in Edematous States
Hypokalemic Normotensive States
Summary