Effect of antenatal spiramycin treatment on the frequency of retinochoroiditis due to congenital toxoplasmosis in a Colombian cohort

Zuluaga, Liliana; Hernández, John Camilo; Castaño, Carlos Felipe; Donado, Jorge

doi:10.7705/biomedica.v37i2.2818

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…In that study, ocular toxoplasmosis was found in 1/15 children (6.6%) from pregnant women who used spiramycin, whereas it was found in 5/8 babies (62.5%) from untreated pregnant women, and in two of these cases, involvement of the central nervous system was verified. 28 …”

Section: Discussionmentioning

confidence: 99%

Characterization of prenatal healthcare for implementation of congenital toxoplasmosis surveillance program: cross-sectional study

Benitez

Gomes

Dias³

et al. 2020

Sao Paulo Med. J.

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The transmission routes for toxoplasmosis include consumption of raw foods, undercooked meats and untreated water; contact with soil contaminated with the evolutionary infective forms of the protozoon Toxoplasma gondii (T. gondii); and transplacental infection. 1 Differences in pregnant women's food intake and cultural habits around the world are responsible for variations in the prevalence of congenital toxoplasmosis among countries, 2 and between communities within the same nation. 3 Preventive measures are common to all populations, since they concentrate on health education and early detection of infection during pregnancy. 4 However, the public health strategies for prevention of this parasitosis need to be appropriate for each situation. T. gondii infection is a major problem within gestational health because of the possibility of irreversibly damaging the fetus. 1 The main types of damage reported have included chorioretinitis, deafness, intracranial calcification, microcephaly, hydrocephalus, seizures and intellectual disability. In addition, occurrences of spontaneous abortions, neonatal death and neurodevelopmental disorders have been recorded. 5 Researchers from the World Health Organization (WHO) reported that in 2010, despite neglect due to little attention given to the prevalence, prevention and treatment of toxoplasmosis, 10.3 million cases of this disease were recorded worldwide, with 825,000 Disability-Adjusted Life Years (DALYs), one of the highest among foodborne parasitic diseases. 2 The Brazilian strains of T. gondii are highly damaging to the eye tissue, in comparison with strains in other countries. 6 However, reduction of the incidence of congenital infection, through early identification of maternal infection and adoption of strategic therapy for pregnant women and

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Section: Discussionmentioning

confidence: 99%

Characterization of prenatal healthcare for implementation of congenital toxoplasmosis surveillance program: cross-sectional study

Benitez

Gomes

Dias³

et al. 2020

Sao Paulo Med. J.

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Secuelas clínicas y neurodesarrollo de pacientes pediátricos con toxoplasmosis congénita en un centro de cuarto nivel

Posada-Bustos,

Mariño,

Espinosa-García

2024

Biomed.

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Introducción. La toxoplasmosis congénita es una enfermedad parasitaria de importante prevalencia a nivel mundial, con gran morbilidad y afectación del neurodesarrollo en pacientes pediátricos.Objetivo. Describir las secuelas y valorar el neurodesarrollo de pacientes pediátricos con toxoplasmosis congénita en el Hospital Militar Central del 2013 al 2020.Materiales y métodos. Se trata de un estudio observacional, descriptivo y de corte transversal, con componente analítico, que incluyó los pacientes pediátricos con diagnóstico de toxoplasmosis congénita que consultaron al Hospital Militar Central durante el periodo de enero de 2013 a diciembre de 2020. En los niños menores de seis años, se utilizó la escala de neurodesarrollo Ages and Stages Questionnaires 3.Resultados. Se incluyeron 45 pacientes con toxoplasmosis congénita confirmada, con una media de edad de 5,9 años; 60 % eran de sexo masculino. El 11,2 % estaban sintomáticos al nacer y el 33 % presentó coriorretinitis. Durante el seguimiento, el 73 % presentó secuelas oftalmológicas; el 64 %, tenía calcificaciones en la tomografía computarizada; el 4,4 %, hidrocefalia; el 11,2 %, parálisis cerebral, y el 13,4 %, epilepsia focal. El 58 % de los menores de seis años presentó compromiso del neurodesarrollo y el 62 % de los mayores de seis años tenía déficit cognitivo. En esta cohorte, el 68 % de los pacientes recibió tratamiento posnatal. Se obtuvo una asociación estadísticamente significativa entre no recibir tratamiento y las secuelas oftalmológicas (OR = 5,2; p < 0,001).Conclusiones. La toxoplasmosis congénita se asoció con secuelas a largo plazo, similares a las descritas en otras series de casos latinoamericanos. Es de suma importancia hacer un diagnóstico temprano, con evaluación, tratamiento y seguimiento interdisciplinario oportunos en los pacientes colombianos para mejorar su pronóstico.

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Effect of antenatal spiramycin treatment on the frequency of retinochoroiditis due to congenital toxoplasmosis in a Colombian cohort

Cited by 2 publications

References 23 publications

Characterization of prenatal healthcare for implementation of congenital toxoplasmosis surveillance program: cross-sectional study

Characterization of prenatal healthcare for implementation of congenital toxoplasmosis surveillance program: cross-sectional study

Secuelas clínicas y neurodesarrollo de pacientes pediátricos con toxoplasmosis congénita en un centro de cuarto nivel

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