Effect of Anthonotha macrophyla (P. Beauv) leaf extract on carrageenan-induced paw oedema, oxidative stress makers and hyperalgesia in murine models

Kumatia, Emmanuel Kofi; Ayertey, Frederick; Appiah–Opong, Regina; Ofori-Attah, Ebenezer; Bolah, Peter; Antwi, Stephen; Appiah, Alfred Ampomah; Ocloo, Augustine

doi:10.1007/s13596-020-00541-8

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…The yield, nature, and phytoconstituents obtained for the extracts were similar to those reported elsewhere [ 20 , 26 , 31 ] because it was the same bath of the plant material used in both studies.…”

Section: Resultssupporting

confidence: 80%

“…Alkaloids were also present in APLE, which contained a greater number of phytochemical constituents among the extracts. e yield, nature, and phytoconstituents obtained for the extracts were similar to those reported elsewhere [20,26,31] because it was the same bath of the plant material used in both studies.…”

Section: Classes Of Phytochemical Constituents In the Extractssupporting

confidence: 78%

“…However, APLE (IC 50 = 110.1 ± 0.12 μ g/mL) was inactive. AMSBE and APLE were shown to demonstrate significant antimalaria activity in mice in vivo [ 20 , 26 ]. However, these extracts were inactive against P. falciparum in vitro.…”

Section: Resultsmentioning

confidence: 99%

“…The plant materials were sun dried for 8 days and pulverized into a coarse powder. Extraction was performed using the protocol of Kumatia et al [ 20 ]. Briefly, the powdered stem bark of A. micraster (200 g) was extracted with 70% ethanol (2 L × 2) at room temperature for four days each filtered and combined.…”

Section: Methodsmentioning

confidence: 99%

“…e stem bark is used to treat venereal diseases and malaria. So far, aphrodisiac, safety, anti-inflammatory, analgesic, and antioxidant activities of the leaf in addition to antiplasmodial activity of the stem bark have been reported [15,[19][20][21]. Antrocaryon micraster (A. Chev.…”

Section: Introductionmentioning

confidence: 99%

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Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts

Dofuor¹,

Kumatia

Chirawurah

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (female Anopheles mosquito and tsetse fly) abound. Various medicinal plants are used to treat these parasitic diseases. However, the scientific basis of their use and toxicological profiles have not been assessed. We have, therefore, evaluated the antiplasmodial, antitrypanosomal, and cytotoxic activities of four African medicinal plant extracts namely, Anthonotha macrophylla leaf (AML), Annickia polycarpa leaf (APLE), Tieghemella heckelii stem bark (THBE), and Antrocaryon micraster stem bark (AMSBE) extracts in vitro against P. falciparum (W2mef laboratory strain), T. brucei (GUTat 3.1 strain), and mammalian RAW 264.7 macrophage cell line, respectively. The most active antiplasmodial extract was AML (IC50 = 5.0 ± 0.08 μg/mL with SI of 21.9). THBE also, produced the most effective antitrypanosomal activity (IC50 = 11.0 ± 0.09 μg/mL and SI of 10.2) among the extracts. In addition, none of the extracts produced toxic effect in the RAW 264.7 macrophage cell line except APLE which was moderately cytotoxic and also produced the least SI in both antitrypanosomal and antiplasmodial assays. These results suggest that AML and THBE could offer safe and alternative therapy for malaria and trypanosomiasis. This is the first study to report the antitrypanosomal and in vitro antiplasmodial activities of these four plants/plant parts. The cytotoxicity of the plant parts used is also being reported for the first time except for the T. heckelii stem bark.

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Section: Resultssupporting

confidence: 80%

Section: Classes Of Phytochemical Constituents In the Extractssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts

Dofuor¹,

Kumatia

Chirawurah

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Aphrodisiac activity of aqueous extract of Anthonotha macrophylla (P. Beauv) leaves in paroxetine-induced sexual dysfunction male Wistar rats

Olutoye,

Yakubu

2025

Journal of Ethnopharmacology

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Antiarthritic and Antioxidant Activities of Antrocaryon micraster Seed Extract and Its Fractions

Kumatia,

Baffour,

Bolah

2024

BioMed Research International

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Rheumatoid arthritis (RA) is an incurable debilitating disease which attacks the joints and impairs quality of life. Antrocaryon micraster is used to treat RA in African traditional medicine. However, its antiarthritic activity has not been pharmacologically studied. This study, therefore, reports the antiarthritic and antioxidant activities of A. micraster seed extract and its fractions. The seed extract (ASE) was produced by Soxhlet extraction and partitioned into petroleum ether (ASEP), ethyl acetate (ASEE), and aqueous (ASEA) fractions. The total polyphenolic content, DPPH antioxidant activity, and in vitro arthritic activity using the protein denaturation assay were evaluated for ASE and its fractions. The arthritic activity of the crude extract (ASE) and its most effective fraction (ASEA), in the in vitro assay, were then evaluated against CFA-induced arthritis in rats. The polyphenolic constituent of ASE was estimated to be 13.00±0.00 mg/100 mg of GAE. ASEA contained the highest quantity of polyphenolic constituents (10.76±0.00 mg/100 mg of GAE) among the fractions of the extract. ASE and ASEA produced profound antioxidant activity (IC50=20.17±1.291 and 19.35±0.865, respectively) which were similar to that of ascorbic acid (IC50=17.35±0.500) in the DPPH free radical scavenging assay. Furthermore, in vitro antiarthritic activity of ASEA was 13.63 and 5.75 times higher than the antiarthritic activity of the crude extract and diclofenac sodium, respectively. In the CFA-induced arthritis assay, both ASE and ASEA significantly (P<0.001) inhibited cachexia, paw edema, infiltration of inflammatory cells, pannus formation, and synovium damage. These results indicate that A. micraster seed extract and its fractions possessed significant antiarthritic activity via inhibition of oxidative stress, inflammation, protein denaturation, infiltration of inflammatory cells, and synovium injury due to its constituents such as polyphenols and phytosterols.

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Effect of Anthonotha macrophyla (P. Beauv) leaf extract on carrageenan-induced paw oedema, oxidative stress makers and hyperalgesia in murine models

Cited by 4 publications

References 35 publications

Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts

Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts

Aphrodisiac activity of aqueous extract of Anthonotha macrophylla (P. Beauv) leaves in paroxetine-induced sexual dysfunction male Wistar rats

Antiarthritic and Antioxidant Activities of Antrocaryon micraster Seed Extract and Its Fractions

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