Effect of anti-asthmatic drugs on dental health: A comparative study

Chellaih, P; Ganapathy, Sivadas; Chintu, S; Vedam, Vaishnavi; Arunachalam, Rajeev; Sarsu, M

doi:10.4103/0975-7406.191973

Cited by 14 publications

(1 citation statement)

References 17 publications

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“…For case-control studies, Hassanpour et al conducted a study comparing 70 asthmatic children receiving inhaled CSs for a year or longer to 70 age-matched healthy children and found significantly higher mean DMFT, mean dmft, in addition to higher mean decayed, missing, and filled teeth in the asthmatic group [ 10 ]. Chellaih et al conducted a study comparing 55 asthmatic patients receiving daily inhaled CSs and bronchodilators for two years or more to 55 healthy subjects and reported significantly higher mean DMFT in the asthmatic group with a risk of 6.26 times to develop caries [ 13 ]. Stensson et al compared 20 asthmatic patients (eight receiving fluticasone with a mean dose of 240 µg/day and salmeterol, and 12 receiving budesonide with a mean dose of 320 µg/day and formoterol) to 20 healthy subjects.…”

Section: Reviewmentioning

confidence: 99%

The Association Between Long-Term Corticosteroids Use and Dental Caries: A Systematic Review

Jan,

Khayat,

Bushnag

et al. 2023

Cureus

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Corticosteroids (CSs) are a group of medications prescribed regularly to treat a wide range of inflammatory and immune-related conditions with great benefit. The impact of long-term use of CSs on the oral cavity has been reported before, including increased risk of periodontal disease and dental caries. Thus, the aim of this study is to evaluate the prevalence of dental caries in patients using CSs. A literature review was completed using PubMed and Cochrane search engines. The search was based on questions related to adults and children (P); corticosteroids (I); no corticosteroids (C); and dental caries (O) (PICO questions) using the keywords “steroids” and “caries” with all relevant variations and MeSH terms. Decay missing filling tooth/decay missing filling surface (DMFT/DMFS) scores were selected as parameters to assess the effects of CSs on caries prevalence. Data was extracted and analyzed for comparisons. The search yielded 1,206 articles from January 2001 to January 2023, of which 21 papers were eligible for analysis. Overall, 14 studies reported an increase in caries with CSs use. However, seven studies failed to report an association of caries prevalence with CSs use. Current evidence supports the correlation between increased risk of caries with chronic CSs use, specifically for inhaler formulation. Future studies with randomized controlled clinical studies are warranted to confirm these findings.

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Section: Reviewmentioning

confidence: 99%

The Association Between Long-Term Corticosteroids Use and Dental Caries: A Systematic Review

Jan,

Khayat,

Bushnag

et al. 2023

Cureus

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Influence of childhood asthma on dental caries: A longitudinal study

Samec

Jan

2021

Clinical & Exp Dental Res

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Objectives: The study investigated the influence of childhood asthma on dental caries development and caries risk factors among children with asthma in Slovenia. Material and methods:The study population consisted of 2-17 years old children (n = 138), who had used anti-asthmatic medicines for at least 1 year. Controls were their non-asthmatic siblings (n = 140). International Caries Detection and Assessment System-II was used to assess caries status. After 3 years, 106 baseline participants (53 asthmatic and 53 siblings) were reexamined. Questionnaires completed by parents and data from the patients' medical records provided information on demographics, child's medical history, medication usage, and oral health behaviors.Additional 308 asthmatic children were examined to assess caries risk factors among children with asthma.Results: Asthmatic children had significantly higher mean d 12 fs and D 12 MFS (p ≤ 0.05), and fewer caries-free individuals (p ≤ 0.01). In asthmatic children, 3 years mean increment in D 12 MFS was significantly higher (p ≤ 0.05). Furthermore, progression over 3 years from sound tooth surfaces to decayed cavitated and filled lesions in primary and permanent teeth were present in significantly higher (p ≤ 0.05) percentage, and likewise transition from decayed cavitated lesions to missing tooth surfaces because of caries in primary teeth, and from filled to filled non-cavitated and cavitated lesions in permanent teeth. Lower caries experience in asthmatic children was associated with lower doses of inhaled glucocorticoid use, leucotriene antagonist use, and daily milk and cheese consumption.Conclusions: Asthmatic children who had used anti-asthmatic medicines had higher caries experience and higher caries progression over 3 years in both primary and permanent dentitions. Besides anti-asthmatic medicines, other factors were associated with higher caries experience in asthmatic children.

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