Effect of anti-tumor necrosis factor α treatment on radiographic progression in patient with ankylosing spondylitis: A systematic review and meta-analysis

Zong, He-Xiang; Xu, Shengqian; Tong, Hui; Wang, Xinrong; Pan, Meijuan; Teng, Yuzhu

doi:10.1080/14397595.2018.1525017

Cited by 16 publications

(10 citation statements)

References 38 publications

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“…Ankylosing spondylitis (AS) is an autoinflammatory disease with a largely unknown etiology. It primarily involves the axial skeleton and is characterized by sacroiliac arthritis and enthesitis with pain, stiffness, and joint deformity [ 1 ]. The pain in AS patients is currently considered as an inflammatory pain (IP).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics

Zhou

et al. 2021

Pain Ther

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Introduction: Pain in ankylosing spondylitis is currently considered an inflammatory pain (IP). However, it was found that some patients still had the sensation of pain even without inflammation. Our study was to investigate the prevalence and characteristics of neuropathic pain (NeP) in Chinese Han ankylosing spondylitis (AS) patients. Methods: The study consisted of three parts. Firstly, we assessed the prevalence and clinical data of NeP in 182 AS patients. Secondly, we evaluated pain improvement after etanercept therapy in 63 patients. Finally, serum neurotransmitters were measured for 20 AS patients and ten healthy controls (HC).Results: Out of 182 AS patients, our study showed that 14 patients (7.70%) had likely NeP and 55 (30.21%) had uncertain NeP. There were significant differences among the three groups with respect to nocturnal pain (NP), peripheral pain (PP), total back pain (TBP), BASDAI, ASDAS-CRP, HAD-A, HAD-D, and BASDAIfatigue except fort CRP concentrations. Principal component analysis (PCA) of AS pain revealed that the weight of NeP was greater than PP in the first principal component (0.703 vs. 0.639). Structural equation modeling (SEM) revealed that NeP altered disease activity (b = 0.62, P \ 0.001), which influenced psychological status (b = 0.42, P \ 0.001). Of 63 patients who used etanercept for 3 months, significant improvement was found in NP, TBP, and PP (all P \ 0.0001) but not in PDQ (10.60 ± 6.85 vs. 9.98 ± 6.40, P = 0.0671). Serum norepinephrine concentrations in patients with PDQ [ 19 were higher than those in patients with PDQ B 19 and HC. Conclusions: We conclude that NeP contributes to pain in AS patients.

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Section: Introductionmentioning

confidence: 99%

Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics

Zhou

et al. 2021

Pain Ther

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“…TNF-α inhibitor treatment clearly improves the functional outcomes, disease activity, and the quality of life of patients who are unresponsive to conventional therapy 1 . However, previous studies have reported inconsistent findings regarding the effect of TNF-α inhibitor treatment on spinal radiographic progression in patients with AS 5–9 , whereas TNF-α inhibitors have been effective in preventing structural damage as well as reducing disease activity in psoriatic arthritis and rheumatoid arthritis (RA), in which bone erosion dominates bone formation 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Effect of tumor necrosis factor inhibition on spinal inflammation and spinal ankylosis in SKG mice

Lim

Lee

Kwon

et al. 2019

Sci Rep

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To prevent spinal progression in ankylosing spondylitis, initiating TNF-inhibitor treatment as early as possible is suggested. However, the outcomes are inconsistent in previous clinical studies. Here, we investigated the effect of TNF inhibition alone on spinal progression when used during arthritis development in a murine model. We injected 8-week-old SKG mice with curdlan (curdlan group). We injected adalimumab at 3 and 9 weeks after the first curdlan injection (ADA group). The clinical scores of peripheral arthritis decreased in the ADA group at 3 weeks after first adalimumab injection. Using positron emission tomography–magnetic resonance imaging and histologic examination, spinal inflammation was observed in the curdlan group, and was significantly deceased in the ADA group. However, spinal osteoblast activities by imaging using OsteoSense 680 EX and bone metabolism-related cytokines such as receptor activator of nuclear factor-kappa B ligand, osteoprotegerin, Dickkopf-1, and sclerostin levels except IL-17A level were not different between the two groups. We conclude that treating TNF inhibitor alone reduced peripheral arthritis score and spinal inflammation in curdlan-injected SKG mice but did not decrease the spinal osteoblast activity, suggesting little effect on spinal ankylosis.

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“… 31 A meta-analysis of 14 studies (3186 patients) with low to moderate risk of bias demonstrated that anti-TNF therapy can significantly improve disease activity and physical function in AS. 32 In this context, caution is needed to interpret our data since the study design did not consider temporality; thus, the influence of any medicine in the improvement in both objective and subjective indicators of disease activity and patient functioning is out of the scope of this research.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Temporomandibular Joint Disorders in Patients with Ankylosing Spondylitis: A Cross-Sectional Study

Souza¹,

Sousa²,

Sousa³

et al. 2021

CCIDE

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Effect of anti-tumor necrosis factor α treatment on radiographic progression in patient with ankylosing spondylitis: A systematic review and meta-analysis

Abstract: Our meta-analysis found no significant effect on delaying radiographic progression in AS treated with TNF α inhibitor, although TNF α inhibitor could do improve significantly disease activity and physical function in AS.

Cited by 16 publications

References 38 publications

Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics

Assessment of Neuropathic Pain in Ankylosing Spondylitis: Prevalence and Characteristics

Effect of tumor necrosis factor inhibition on spinal inflammation and spinal ankylosis in SKG mice

Prevalence of Temporomandibular Joint Disorders in Patients with Ankylosing Spondylitis: A Cross-Sectional Study

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