Effect of anti-α-fetoprotein serum on human hepatoblastoma

Hata, Yoshinobu; Uchino, Junichi; Sasaki, Fumio; Une, Yoshie; Naito, Haruhiko; Sato, Koichi; Kukita, Kazutaka; Sano, Hidekazu; Kasai, Yoichi; Tsutsumi, Yutaka; Hirai, Hidematsu

doi:10.1016/s0022-3468(84)80107-4

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…Alongside the use of AFP in obstetrics, it is described as a liver tumour marker, as neoplastic cells originating from hepatocytes usually retain the ability to produce AFP (Tatarinov, 1964 ); thus, anti‐AFP antibodies can be used in immunohistochemical staining (Wu et al., 1997 ) and therapy after conjugation with cytotoxic drugs (Hata et al., 1984 ; Kato et al., 1983 ).…”

Section: Hormonesmentioning

confidence: 99%

Markers for internal neoplasia in the horse

Drozdzewska

Gehlen

2022

Veterinary Medicine & Sci

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The diagnosis of internal neoplasia in horses is challenging. Increased production of hormones physiologic for adult animals (e.g., adrenocorticotropin, norepinephrine, and erythropoietin) or typical for the foetal phase (alpha‐fetoprotein, anti‐Müllerian hormone, and parathyroid‐hormone‐related protein) might aid in tumour diagnostics. Thymidine kinase‐1 and alkaline phosphatase are examples of intracellular enzymes, whose activity in the blood may increase in some neoplasia cases. Furthermore, inappropriate production of abnormal monoclonal or autologous antibodies can accompany lymphoma and multiple myeloma. Many of those tumour markers lead to clinical or laboratory changes, called paraneoplastic syndromes, such as hypercalcaemia and erythrocytosis. The interpretation of the results of the tumour marker measurements in horses is complicated due to many factors affecting the markers’ concentration or activity (e.g., young age, pregnancy, and inflammation) and other diseases triggering the same changes. Moreover, the presence of paraneoplastic syndromes is inconsistent, which leads to low sensitivity of those substances as tumour markers. In conclusion, screening for neoplasia in horses is not recommended. The measurement of tumour markers should be performed only in risk groups with suspicious clinical or laboratory findings, and the results should be interpreted with caution. It is advisable to add inflammatory markers to the tumour profile or repeat the measurements.

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Section: Hormonesmentioning

confidence: 99%

Markers for internal neoplasia in the horse

Drozdzewska

Gehlen

2022

Veterinary Medicine & Sci

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“…CD40 expression and function has been described on a variety of cell types [4][5][6][7] , including neurons 8 . Activation of the CD40 pathway is well-known to promote proliferation, survival, differentiation and maturation in a variety of immune and other cell types [9][10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Modulation of neuronal differentiation by CD40 isoforms

Hou

Obregon

Lou

et al. 2008

Biochemical and Biophysical Research Communications

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Neuron differentiation is a complex process involving various cell-cell interactions, and multiple signaling pathways. We showed previously that CD40 is expressed and functional on mouse and human neurons. In neurons, ligation of CD40 protects against serum withdrawal-induced injury and plays a role in survival and differentiation. CD40 deficient mice display neuron dysfunction, aberrant neuron morphologic changes, and associated gross brain abnormalities. Previous studies by Tone and colleagues suggested that 5 isoforms of CD40 exist with 2 predominant isoforms expressed in humans: signal-transducible CD40 type I and a C-terminal truncated, non-signaltransducible CD40 type II. We hypothesized that differential expression of CD40 isoform type I and type II in neurons may modulate neuron differentiation. Results show that adult wild-type, and CD40 −/− deficient mice predominantly express CD40 type I and II isoforms. Whereas adult wildtype mice express mostly CD40 type I in cerebral tissues at relatively high levels, in age and gender-matched CD40 −/− mice CD40 type I expression was almost completely absent; suggesting a predominance of the non-signal-transducible CD40 type II isoform. Younger, 1 day old wildtype mice displayed less CD40 type I, and more CD40 type II, as well as, greater expression of soluble CD40 (CD40L/CD40 signal inhibitor), compared with 1 month old mice. Neuron-like N2a cells express CD40 type I and type II isoforms while in an undifferentiated state, however once induced to differentiate, CD40 type I predominates. Further, differentiated N2a cells treated with CD40 ligand express high levels of neuron specific nuclear protein (NeuN); an effect reduced by anti-CD40 type I siRNA, but not by control (non-targeting) siRNA. Altogether these data suggest that CD40 isoforms may act in a temporal fashion to modulate neuron differentiation during brain development. Thus, modulation of neuronal CD40 isoforms and CD40 signaling may represent important therapeutic modalities for neurodegenerative and neurodevelopmental disorders, as well as, for enhancement of neurogenesis.

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Hepatoblastoma

Stocker¹,

Ishak²

1987

Neoplasms of the Liver

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Effect of anti-α-fetoprotein serum on human hepatoblastoma

Cited by 4 publications

References 3 publications

Markers for internal neoplasia in the horse

Markers for internal neoplasia in the horse

Modulation of neuronal differentiation by CD40 isoforms

Hepatoblastoma

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