Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Ammar, H. O.; Ghorab, Mostafa M.; Felton, Linda A.; Gad, Shadeed; Fouly, Aya Adel

doi:10.1208/s12249-015-0397-7

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…This is a mechanical property measured to ensure the strength of films and is relatively low with soft and weak polymers. The tensile strength values of NLC-loaded (0.407 N/cm 2 ) and placebo (0.394 N/cm 2 ) films were comparable and indicated sufficient strength [37].…”

Section: Characterization Of Nlc-loaded Buccal Mucoadhesive Filmmentioning

confidence: 86%

“…The tensile strength of the optimized NLC-loaded film and placebo was measured using a texture analyzer (QTS-25, Brookfield Engineering Labs, Middleboro, MA, USA) calibrated with a 5 kg load cell [37]. The films were cut into 7 cm length and 2 cm width strips and fixed between two tensile grips positioned 3 cm apart.…”

Section: Tensile Strengthmentioning

confidence: 99%

“…The films were subjected to a tensile test at a speed of 20 mm/s until they reached their breaking point. The tensile strength was measured according to the formula described in the literature [37].…”

Section: Tensile Strengthmentioning

confidence: 99%

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Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers

AlMulhim,

Nair,

Aldhubiab

et al. 2023

Pharmaceutics

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The therapeutic effectiveness of paliperidone in the treatment of schizophrenia has been limited by its poor oral bioavailability; hence, an alternative route could be appropriate. This study investigates the feasibility of developing a buccal film impregnated with paliperidone-loaded nanostructured lipid carriers (NLCs) and assesses the potential to enhance its bioavailability. Box–Behnken-based design optimization of NLCs was performed by examining the particles’ physical characteristics. The polymeric film was used to load optimized NLCs, which were then assessed for their pharmaceutical properties, permeability, and pharmacokinetics. The optimization outcomes indicated that selected formulation variables had a considerable (p < 0.05) impact on responses such as particle size, entrapment efficiency, and % drug release. Desired characteristics such as a negative charge, higher entrapment efficiency, and nanoparticles with ideal size distribution were shown by optimized NLC dispersions. The developed film demonstrated excellent physico-mechanical properties, appropriate texture, good drug excipient compatibility (chemically stable formulation), and amorphous drug nature. A sustained Weibull model drug release (p < 0.0005) and superior flux (~5-fold higher, p < 0.005) were seen in NLC-loaded film compared to plain-drug-loaded film. The pharmacokinetics profile in rabbits supports the goal of buccal therapy as evidenced by significantly higher AUC0–12 (p < 0.0001) and greater relative bioavailability (236%) than the control. These results support the conclusion that paliperidone-loaded NLC buccal film has the potential to be an alternate therapy for its effective administration in the treatment of schizophrenia.

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Section: Characterization Of Nlc-loaded Buccal Mucoadhesive Filmmentioning

confidence: 86%

Section: Tensile Strengthmentioning

confidence: 99%

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Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers

AlMulhim,

Nair,

Aldhubiab

et al. 2023

Pharmaceutics

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“…12,24 Anti-adherent materials, such as Talc 25,26 and Glyceryl monostearate, 27 are employed to reduce film tackiness and prevent substrate agglomeration. 12,28 Additionally, surfactants like P-80, 29 sorbitan monooleate, 30 and sodium dodecyl sulfate 31 are utilized to emulsify water-insoluble plasticizers, improve substrate wettability, and stabilize suspensions, thereby enhancing the overall properties of the enteric coat film. 12,29 Generic drugs are manufactured by pharmaceutical companies in accordance with FDA.…”

Section: Introductionmentioning

confidence: 99%

Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic tablets

Arafat,

Sakkal,

Bostanudin

et al. 2023

F1000Res

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Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to provide adequate protection. This study is the first to investigate the potential effects of coating materials on the protective functionality of enteric coating films for pantoprazole (PNZ) generic tablets after their recall from the market. Methods: A comparative analysis was conducted between generic and branded PNZ products, using pure drug powder for identification. The in vitro release of the drug was evaluated in different pH media. The study also utilized various analytical and thermal techniques, including differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and confocal Raman microscopy. Results: The in vitro assessment results revealed significant variations in the release profile for the generic product in acidic media at 120 min. DSC and TGA thermal profile analyses showed slight variation between the two products. XRD analysis exhibited a noticeable difference in peak intensity for the generic sample, while SEM revealed smaller particle sizes in the generic product. The obtained spectra profile for the generic product displayed significant variation in peaks and band intensity, possibly due to impurities. These findings suggest that the excipients used in the enteric coating film of the generic product may have affected its protective functionality, leading to premature drug release in acidic media. Additionally, the presence of polysorbate 80 (P-80) in the brand product might improve the properties of the enteric coating film due to its multi-functionality. Conclusions: In conclusion, the excipients used in the brand product demonstrated superior functionality in effectively protecting the drug molecule from acidic media through the enteric coating film, as compared to the generic version.

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A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

et al. 2016

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2 ABSTRACTPurpose. The fabrication of a ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This work aims to adapt a widely used pharmaceutical grade polymer, polyvinylpyrrolidone (PVP), for instant on-demand production of immediate release tablets via FDM 3D printing.Methods. Dipyridamole or theophylline loaded filaments were produced via processing a physical mixture of API (10%) and PVP in the presence of plasticizer through hot-melt extrusion (HME). Computer software was utilized to design a capletshaped tablet. The surface morphology of the printed tablet was assessed using scanning electron microscopy (SEM). The physical form of drug and its integrity following an FDM 3D printing were assessed using x-ray powder diffractometry (XRPD), thermal analysis and HPLC. In vitro drug release studies for all 3D printed tablets were conducted in a USP II dissolution apparatus.Results. Bridging 3D printing process with HME in the presence of a thermostable filler, talc, enabled the fabrication immediate release tablets at temperatures as low as 110 o C. The integrity of two models drugs was maintained following HME and FDM 3D printing. XRPD indicated that a portion of the loaded theophylline remained crystalline in the tablet. The fabricated tablets demonstrated excellent mechanical properties, acceptable in-batch variability and an immediate in vitro release pattern. Conclusions.Combining the advantages of PVP as an impeding polymer with FDM 3D printing at low temperatures, this approach holds a potential in expanding the spectrum of drugs that could be used in FDM 3D printing for on demand manufacturing of individualised dosage forms.

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Effect of Antiadherents on the Physical and Drug Release Properties of Acrylic Polymeric Films

Cited by 10 publications

References 36 publications

Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers

Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers

Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic tablets

A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets

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