Effect of Antibiotic Therapy in Asthenozoospermic Men Associated with Increased Agglutination and Minimal Leukospermia

Carranza-Lira, Sebastián; Tserotas, Konstantinos; Morán, Carlos; Merino, G; Barahona, Edgar; Bermúdez, José

doi:10.3109/01485019808987939

Cited by 12 publications

(10 citation statements)

References 24 publications

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“…After screening abstracts and titles, we excluded 1,083 studies. A total of 30 articles were read in full and evaluated and 11 articles subsequently met the criteria for the systematic review [1011121314151617181920]. Nineteen articles were excluded (non-RCT, 9; duplication, 7; did not meet eligibility, 3) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, Merino and Carranza-Lira [13] found that a statistically significant difference in seminal pH was shown in the group treated with trimethoprim/sulfamethoxazole compared with placebo. In addition, Carranza-Lira et al [18] reported a decrement of the number of normal sperm in the quinolone group compared with the trimethoprim/sulfamethoxazole group. One trial reported significant improvement of sperm motility and morphology using data from all participants who had antibiotic treatment (co-trimoxazole, tetracycline, trimethoprim) (Table 2) [16].…”

Section: Resultsmentioning

confidence: 99%

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Treatment of Leukocytospermia in Male Infertility: A Systematic Review

Jung

Kim

et al. 2016

World J Mens Health

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Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies. However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Treatment of Leukocytospermia in Male Infertility: A Systematic Review

Jung

Kim

et al. 2016

World J Mens Health

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“…In addition, they observed that frequent ejaculation improved the efficacy of antibacterial chemotherapy. Carranza‐Lira et al. (1998) compared two antibacterial treatments (trimethoprim‐sulphamethoxazole and ciprofloxacin), but did not include an untreated group.…”

Section: Discussionmentioning

confidence: 99%

Treatment with levofloxacin does not resolve asymptomatic leucocytospermia - a randomized controlled study

et al. 2003

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The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to bacterial infection. However, the efficacy of antibiotic therapy was not unequivocally demonstrated until now. We started a prospective, randomized, controlled study in 36 patients, who consulted our department for infertility with leucocytospermia. None of the patients reported any symptoms of genital infection. The patients were assigned randomly to two groups: group 1 received 250 mg levofloxacin once a day over 10 days, patients of group 2 received no therapy. Semen analysis was repeated 2 weeks later. After administration of levofloxacin, a mean decrease of leucocyte count of 45.8 +/- 72.2% compared with a decrease of only 3 +/- 109.2% in the untreated group was observed. However, this difference is not statistically significant. There were no significant differences between the two groups with respect to leucocyte count, sperm count and sperm cell after treatment. We conclude from our study that antibiotic therapy does not provide benefit for treatment of asymptomatic leucocytospermia.

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“…Also ciprofloxacin had resulted in a significant reduction of semen leukocytic count with a significant improvement in sperm motility and activity in infertile patients 6 . While other studies revealed that the average of morphologically normal sperms significantly decreased after ciprofloxacin treatment in patients with asthenozoospermia and semen analysis suggestive of infection 2 .…”

Section: Introductionmentioning

confidence: 85%

“…Antibiotic administration modifies some of the spermatic parameters (specially motility and morphology) in patients whose semen analysis suggested infection 2 . Among these antibiotics are quinolones which are a group of antibacterial agents with broad spectrum activity 1 .…”

Section: Introductionmentioning

confidence: 99%

Effect of Ciprofloxacin on Semen Analysis in Human Healthy Volinteers

Vartan¹

2003

Basrah Journal of Surgery

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The effect of ciprofloxacin treatment on semen analysis was studied. Six apparently healthy volunteers with age ranging from 30-51 years were included in this study. Ciprofloxacin tablet (500 mg) was given to each volunteer twice daily for 14 days. Semen analysis was performed for them before ciprofloxacin treatment and 2,4 and 6 weeks after treatment. Four weeks after treatment, there was a statistically significant reduction in total sperm count by 53.4% (from 157.16 ± 23.7 to 73.17 ± 19 millions, p < 0.001), in percentage of actively motile sperms by 40.5% (from 35±7.06 to 20.83± 5.23, p<0.001) and in percentage of viable sperms by 15.2% (from 67.6 ± 6.01 to 57.33± 9.48, p < 0.025). It is concluded that administration of ciprofloxacin (500 mg x 2 for 2 weeks) had, therefore, resulted in a significant reduction of various parameters of semen analysis. A finding, if proved to be true, should be taken in consideration during ciprofloxacin treatment for any type of infection in males.

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Effect of Antibiotic Therapy in Asthenozoospermic Men Associated with Increased Agglutination and Minimal Leukospermia

Cited by 12 publications

References 24 publications

Treatment of Leukocytospermia in Male Infertility: A Systematic Review

Treatment of Leukocytospermia in Male Infertility: A Systematic Review

Treatment with levofloxacin does not resolve asymptomatic leucocytospermia - a randomized controlled study

Effect of Ciprofloxacin on Semen Analysis in Human Healthy Volinteers

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