Effect of Antibiotics on Vulvovaginal Candidiasis: A MetroNet Study

Abstract

Purpose: Vulvovaginal candidiasis (VVC) is believed common after systemic antibiotic therapy, yet few studies demonstrate this association. In this pilot study, we evaluate the effect of short-course oral antibiotic use on VVC.Methods: Nonpregnant women aged 18 to 64 years who required >3 days oral antibiotics for nongynecological diseases were recruited from a family medicine office. Age-matched (؎5 years) women seen in the same clinic for noninfectious problems were recruited as controls. The main outcomes are incidence of symptomatic VVC and prevalence of positive vaginal Candida culture 4 to 6 weeks after antibiotics.Results Although vulvovaginal candidiasis (VVC) is one of the most common forms of vaginitis in women of childbearing age, its etiology remains poorly understood.

Prevalence of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis among pregnant women receiving antenatal care in Southwestern Nigeria

“…The prevalence of VVC was 80% among antibiotics users, as eight out of the ten women who had taken antibiotics recently had VVC compared with 31% among nonusers (28 out of 90), which is highly suggestive of a positive correlation between recent antibiotics ingestion and development of vulvovaginal candidiasis. This relationship was also statistically signifi cant in agreement with several other studies that have linked candidiasis to ingestion of antibiotics [29][30][31]. A similar relationship was also found with bacterial vaginosis (70% vs. 34%), which was signifi cant as well.…”

Prevalence and comparison for detection methods of Candida species in vaginal specimens from pregnant and non pregnant Saudi women

“…In the current study, there was no significant correlation between the incidence of Candida-culture positive from women who previously used oral contraceptives (P= 0.146) or antibiotics (P=0.128) and those who did not, whereas other studies showed significant correlation in this regard (Yusuf et al, 2007;Xu et al, 2008;Bahram et al, 2009). Also some reports found no evidence of an association between antibiotic-drugs and symptomatic VVC, whereas others concluded otherwise (Xu et al, 2008).…”

“…Also some reports found no evidence of an association between antibiotic-drugs and symptomatic VVC, whereas others concluded otherwise (Xu et al, 2008). This discrepancy is apparently due to differences in size of studied women subjects, duration and types of used contraceptives or antibiotics, as well as methods of yeast-detection.…”

Efficacy of anti-microbial agents on vaginal microorganisms and reproductive performance of synchronized estrus ewes

“…Likewise, Glover and Larsen [24] concluded that the extensive antibiotic use posed little risk for the development of fungus infection. In the same line, Jinping et al [25] hypothesized that baseline fungus culture obtained from vagina requiring antibiotic therapy may develop symptomatic vulvovaginal mycotic infection after antibiotic therapy. Similarly, Bluestein et al [26] reported 35% fungus colonization at baseline increased to 50% after 10 d of antibiotic therapy.…”