2015
DOI: 10.1016/j.rpsmen.2015.03.001
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Effect of anticholinergic drugs on cognitive impairment in the elderly

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Cited by 12 publications
(8 citation statements)
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“…Physicians must be aware that, in addition to classical atropinic antiparkinsonian drugs, several others such as psychotropics also possess lateral atropinic effects that can be clinically importantly harmful for PD patients. With regard to the well‐established putative consequences of this widespread use of atropinics (serious adverse drug reactions for a reduced clinical efficacy), large, widespread information campaigns for minimizing atropinic prescriptions in PD patients should be urgently undertaken. Atropinic risk scales, like Duran's list can help prescribers in clinical practice.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Physicians must be aware that, in addition to classical atropinic antiparkinsonian drugs, several others such as psychotropics also possess lateral atropinic effects that can be clinically importantly harmful for PD patients. With regard to the well‐established putative consequences of this widespread use of atropinics (serious adverse drug reactions for a reduced clinical efficacy), large, widespread information campaigns for minimizing atropinic prescriptions in PD patients should be urgently undertaken. Atropinic risk scales, like Duran's list can help prescribers in clinical practice.…”
Section: Resultsmentioning
confidence: 99%
“…In fact, the benefit‐harm balance of atropinic drugs is widely debated in general populations and especially in the elderly because they can induce several adverse drug reactions that are often “serious”: intestinal paresis, xerostomia, blurred vision, increase in heart rate, dyspepsia, dizziness, confusion, memory loss, or cognitive impairment . In older patients, they increased the risk of falls, and their use was associated with increased mortality .…”
Section: Atropinic Risk Scalesmentioning
confidence: 99%
“…For this we may need to improve knowledge and understanding of anticholinergic medicines and switch patients' prescriptions to lower anticholinergic burden when they are at risk of falls (or confusion). 35 In addition, we would explore ways in which the electronic prescribing record system could alert to the need for a medicines review following medicines reconciliation documentation as described by Graabaek et al . 36 …”
Section: Discussionmentioning
confidence: 99%
“…Cholinergic deficit plays a central role in the pathophysiology of Alzheimer's disease. The muscarinic system in the central nervous system mediates processes of attention, learning and short‐term memory; therefore, the use of anticholinergic drugs can produce impaired cognitive function, drowsiness, delirium, hallucinations, confusion, an increased risk of falls and poor quality of life …”
Section: Introductionmentioning
confidence: 99%