Effect of antidepressants on various periodontal parameters: A case–control study

Bey, Afshan; Ahmad, Syed Saeed; Azmi, Sarfuddin; Ahmed, Sheikh Salahuddin

doi:10.4103/jisp.jisp_210_19

Cited by 8 publications

(11 citation statements)

References 20 publications

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“…Among these drugs, imipramine and amitriptyline belong to the tricyclic antidepressant (TCA) class, while other FIASMAs belong to the class of selective serotonin reuptake inhibitor (SSRI) or serotonin‐norepinephrine reuptake inhibitor (SNRI). A recent clinical study reported that both SSRI and SNRI had no significant effect on periodontitis 37 . Interestingly, Hasan et al reported recently that periodontal application of 1% amitriptyline gel or 1% amitriptyline mouthwash for 4 weeks reduced periodontal parameters and inflammatory biomarkers in patients with periodontitis 38 .…”

Section: Discussionmentioning

confidence: 99%

“…A recent clinical study reported that both SSRI and SNRI had no significant effect on periodontitis. 37 Interestingly, Hasan et al reported recently that periodontal application of 1% amitriptyline gel or 1% amitriptyline mouthwash for 4 weeks reduced periodontal parameters and inflammatory biomarkers in patients with periodontitis. 38 Our present study also showed that imipramine attenuated MetS-exacerbated periodontitis in animal model.…”

Section: Ta B L Ementioning

confidence: 99%

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Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss

Zhang

et al. 2021

J of Periodontal Research

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Background and objective: Clinical studies have shown that metabolic syndrome (MetS) exacerbates periodontitis. However, the underlying mechanisms remain largely unknown. Since our animal study has shown that high-fat diet-induced MetS exacerbates lipopolysaccharide (LPS)-stimulated periodontitis in mouse model and our in vitro study showed that acid sphingomyelinase (aSMase) plays a key role in the amplification of LPS-triggered pro-inflammatory response by palmitic acid (PA) in macrophages, we tested our hypothesis that inhibitor of aSMase attenuates MetSexacerbated periodontitis in animal model. Furthermore, to explore the potential underlying mechanisms, we tested our hypothesis that aSMase inhibitor downregulates pro-inflammatory and pro-osteoclastogenic gene expression in macrophages in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Ta B L Ementioning

confidence: 99%

Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss

Zhang

et al. 2021

J of Periodontal Research

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“…Our finding suggests that patients using anti-depressants were over four times more likely to lose favorable teeth in the short term. A recent study also reported that increased periodontal inflammatory parameters, increased pocket depths, and clinical attachment loss were more significant in patients that used anti-depressants than the controlled subjects [ 23 ]. Although the mechanism of this outcome is still not fully understood, patients with mental health issues are often at a greater risk of oral health problems due to poor nutrition, inadequate oral hygiene, and poor compliance [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

The Pattern of Tooth Loss for Periodontally Favorable Teeth: A Retrospective Study

Yanni

Curtis

Kao

et al. 2022

Biology

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To retrospectively analyze local and systemic factors that resulted in the short-term tooth loss of teeth that were previously assigned a favorable prognosis in patients who were seen and treated over an observational five-year period. This retrospective study included the records of patients who had a minimum of two dental exams at least twelve months apart over a 5-year period. This study investigated extracted teeth with an initially favorable periodontal prognosis that were then divided into one of four categories based on the reason for extraction: caries, periodontal disease, endodontic reasons, or fracture. Patient- and tooth-related factors associated with the extracted teeth were recorded: crown-to-root ratio, initial pocket depth, initial periodontal diagnosis, maintenance interval, presence of existing restoration, furcation involvement, and systemic conditions. Data analysis was performed using a linear mixed model. A total of 50 patients with 111 teeth met the inclusion criteria for this study. A higher odds ratio (OR) for tooth loss due to caries, endodontic reasons, and fracture were found in teeth with a history of root canal treatment with an OR of 3.61, 3.86, and 2.52, respectively. For tooth loss due to periodontal disease, higher ORs were found in patients who were on anti-depressants (OR = 4.28) and patients who had an initial diagnosis of Stage III/IV periodontitis (OR = 2.66). In addition, teeth with initial probing depths ≥5 mm (OR = 4.32) and with furcation involvement (OR = 1.93) showed a higher OR for tooth loss due to periodontal disease. Within the limitations of this study, previously root-canal-treated teeth present a higher OR for early loss due to caries, recurrent endodontic lesions, or fracture. In addition, patients with anti-depressant medication use, sporadic maintenance, initial probing depths ≥5 mm, and furcation involvement represent a significantly higher OR of tooth loss due to periodontal disease even for initially favorable teeth.

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“…31,32 In contrast, Bey et al showed that the use of SNRI and SSRI did not improve periodontal parameters in patients with moderate-to-severe depression. 33 Considering the high usage of antidepressant in labeled and off-label, there is a critical need for clinicians to determine whether antidepressant medications affect periodontal health, and whether the effect, if it exists, is associated with certain pharmacological groups of antidepressants. Therefore, this retrospective study aimed to determine the relationship of antidepressants with periodontal diseases, exploring the association of different pharmacological classes of antidepressant with clinical attachment loss (CAL) and alveolar bone level (BL) in patients with periodontitis.…”

Section: Introductionmentioning

confidence: 99%

“…Bhatia's studies reported that the use of SSRI and SNRI was associated with lower numbers of deep pockets, and improvements in bleeding on probing and clinical attachment loss (CAL) in patients with periodontitis and depression 31,32 . In contrast, Bey et al showed that the use of SNRI and SSRI did not improve periodontal parameters in patients with moderate‐to‐severe depression 33 . Considering the high usage of antidepressant in labeled and off‐label, there is a critical need for clinicians to determine whether antidepressant medications affect periodontal health, and whether the effect, if it exists, is associated with certain pharmacological groups of antidepressants.…”

Section: Introductionmentioning

confidence: 99%

Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study

Hakam

Duarte

Mbadu

et al. 2021

J of Periodontal Research

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Objective: Our study aimed to determine the relationship of antidepressant medicine use with periodontal diseases, exploring the association of different pharmacological classes of antidepressant with observations of clinical attachment loss (CAL) and alveolar bone level (BL) in patients with periodontitis. Background: Existing evidence on the impact of antidepressant medication on periodontal tissues has focused on some classes only and is still unclear. Therefore, this retrospective study evaluated the association of different antidepressant classes with clinical attachment loss (CAL) and alveolar bone level (BL). Methods: This study was carried out in a population of patients aged ≥ 30 years old with periodontitis who sought treatment at the University of Florida from 2014 to 2018. The following variables were obtained from patients' records; usage of antidepressant medications and their pharmacological classes (selective serotonin reuptake inhibitors [SSRI], serotonin-norepinephrine reuptake inhibitors [SNRI], tricyclic, atypical, and monoamine oxidase inhibitors [MAO]), age, gender, smoking habit, mild systemic diseases, CAL, and cement-enamel junction (CEJ) and alveolar bone crest (BC) distance, defined as BL, in the Ramfjord index teeth.Results: Five hundred and eighty-two periodontitis patients were evaluated, of which 113 (19.4%) were antidepressant users. Antidepressant users exhibited significantly lower BL and fewer sites with severe CAL (≥5 mm), than non-users (p < .05). Among all single-class antidepressant users, the SSRI users showed significantly less CAL and lower BL than non-users (p < .05). Patients taking combinations of the different classes of antidepressants also showed better CAL and BL than non-users. Generalized linear models, including variables such as gender, age, systemic diseases, and smoking, demonstrated that antidepressant users were more likely to have lower mean BL and fewer sites with severe bone loss (i.e. BL > 3 and >5 mm) than non-users (p < .05).Conclusions: Antidepressant medications were associated with higher alveolar bone level and less clinical attachment loss in patients with periodontitis. When the different classes of antidepressants were analyzed individually, only the SSRI class

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Effect of antidepressants on various periodontal parameters: A case–control study

Cited by 8 publications

References 20 publications

Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss

Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss

The Pattern of Tooth Loss for Periodontally Favorable Teeth: A Retrospective Study

Association of different antidepressant classes with clinical attachment level and alveolar bone loss in patients with periodontitis: A retrospective study

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