Effect of antiepileptic drugs on the elimination of various tetracycline derivatives

Neuvonen, Pertti J.; Penttilä, O; Lehtovaara, R.; Aho, Kimmo

doi:10.1007/bf00614011

Cited by 38 publications

(13 citation statements)

References 12 publications

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“…The t1/2sb of doxycycline was shortened from 929 ± 180 min with placebo to 539 ± 108 min (P < 0.01) when doxycycline was administered with pirenzepine. Previous studies reported an acceleration of elimination when doxycycline was given to patients receiving long-term therapy with barbiturates or anticonvulsants or after long-term alcohol consumption (27)(28)(29). In our investigation, volunteers received only a 1-day treatment with pirenzepine.…”

Section: Discussionmentioning

confidence: 99%

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Deppermann

Lode

Höffken

et al. 1989

Antimicrob Agents Chemother

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Two randomized double-blind crossover studies and one randomized crossover study were performed to document possible drug-drug interactions between antacids (aluminum magnesium hydroxide, 10 ml per dose for 10 doses), antimuscarinic drugs (pirenzepine, 50 mg per dose for 4 doses), and H2-blockers (ranitidine, 150 mg per dose for 3 doses) and amoxicillin (1,000 mg), cephalexin (1,000 mg), doxycycline (200 mg), and amoxicillin-clavulanic acid (625 mg). Ten healthy volunteers participated in each study. Concentrations in serum and urine were measured by bioassay, and pharmacokinetic parameters were calculated by the usual open one-or two-compartment models (statistics were determined by the Wilcoxon test). The antacid, pirenzepine, and ranitidine had no influence on the bioavailability of amoxicillin, cephalexin, and amoxicillinclavulanic acid. Only small differences could be observed in the pharmacokinetic parameters, but they are not of therapeutic importance. However, the antacid caused a significant (P < 0.01) reduction in the gastrointestinal absorption of doxycycline (area under the concentration-time curve, 38.6 + 22.7 mg * h/liter, fasting; 6.0 + 3.2 mg. h/liter, with antacid), resulting in subtherapeutic levels of doxycycline.

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Section: Discussionmentioning

confidence: 99%

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Deppermann

Lode

Höffken

et al. 1989

Antimicrob Agents Chemother

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“…Increased rate of drug clearance in patients on antiepileptic drugs have been reported (Petruch, Schuppel & Steinhilber, 1974;Welch, DeAngelis, Wingfield & Farmer, 1975;Neuvonen, Penttila, Lehtovaara & Aho, 1975;Stevenson, O'Malley & Shepherd, 1976). Billing & Black (1971) demonstrated a significant rise in the microsomal cytochrome P-450 content in biopsies of subjects treated with phenobarbitone for a week before abdominal surgery, and Remmer, Schoene, Fleischmann & Held (1973) showed increased activities of drug-metabolizing enzymes in liver biopsy of a female epileptic treated with phenytoin and phenobarbitone.…”

Section: Introductionmentioning

confidence: 94%

Drug metabolism in epileptics: in vivo and in vitro correlations.

Ea¹,

Pelkonen²,

Ahokas³

et al. 1978

Brit J Clinical Pharma

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I The effect of inducing drug therapy on the relationship between in vitro (cytochrome P-450 content) and in vivo (antipyrine kinetics) was investigated by comparing eleven consecutively treated epileptics with two groups of controls, eleven subjects with normal liver histology and eleven disease matched non-epileptics, all underwent diagnostic liver biopsy. 2 The epileptics had significantly higher cytochrome P-450 level in biopsies and they also metabolized antipyrine taster than the controls. 3 Decrease in antipyrine half-life in epileptics was related with alterations in liver histology, whereas the level of cytochrome P-450 was not. 4 There was a linear relationship between these two indices of enzyme induction when regressed on logarithmic data.

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“…Barbiturates, carbamazepine, and phenytoin are believed to decrease the half-life of doxycycline by inducing microsomal enzyme activity 41,120. It has been suggested to double the doxycycline dosage (take twice daily) in those taking antiepileptics 120…”

Section: Drug Interactionsmentioning

confidence: 99%

Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

Tan¹,

Magill²,

Parise³

et al. 2011

The American Society of Tropical Medicine and Hygiene

185

134

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Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.

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Effect of antiepileptic drugs on the elimination of various tetracycline derivatives

Cited by 38 publications

References 12 publications

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid

Drug metabolism in epileptics: in vivo and in vitro correlations.

Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

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