Effect of antiepileptic drugs on serum biochemical marker levels of first and second trimester screening tests

Besimoğlu, Berhan; Öcal, Fatma Doğa; Sınacı, Selcan; Atalay, Altay; Şahın, Dilek

doi:10.1111/jog.15250

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Antiepileptic drugs such as lamotrigine, levetiracetam, carbamazepine, oxcarbamazepine, valproic acid and clonazepam affect the increase in AFP and E3 levels in the second trimester of pregnancy [64].…”

Section: Medicines and Supplementsmentioning

confidence: 99%

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Głowska-Ciemny¹,

Szymański²,

Pankiewicz³

et al. 2023

Ginekol Pol

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Alpha-fetoprotein (AFP) is one of the biochemical components of the triple (T-3) and quadruple (T-4) test used so far in prenatal screening mainly for trisomy 21 (T21) and neural tube defects (NTDs). Based on many years of experience and data collected during these studies, a variety of factors have been identified that can affect a pregnant woman's serum AFP level, and thus the risk assessment of trisomy 21 (T21) and neural tube defects. These include both unaccounted for purely medical data (e.g., from baseline information about the patient, assisted reproduction methods used, comorbidities and emerging pregnancy pathologies) and errors made during statistical analysis. Since the triple or quadruple test is usually performed between 15 and 20 weeks of pregnancy, most scientific studies are based solely on results from this period of pregnancy -limited data are available for the first and third trimesters of pregnancy. In the era of new improved screening tests, AFP has the potential to become an independent marker for pregnancy well-being evaluation.

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Section: Medicines and Supplementsmentioning

confidence: 99%

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Głowska-Ciemny¹,

Szymański²,

Pankiewicz³

et al. 2023

Ginekol Pol

View full text Add to dashboard Cite

show abstract

First and second trimester laboratory changes and perinatal outcomes in pregnant women with epilepsy

Şeyhanlı,

Ulusoy,

Karabay

et al. 2024

Journal of Health Sciences and Medicine

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Aims: The aim of this study is to comprehensively evaluate the demographic, first-second trimester laboratory parameters and perinatal outcomes in pregnant women with epilepsy. Methods: The study had a total of 73 pregnant women with epilepsy, along with 149 healthy pregnant women. Demographic data, first-second trimester laboratory parameters, seizures during pregnancy, the administration of antiepileptic medicines and perinatal outcomes were documented from September 2022 to 2023. Pregnant women with epilepsy were formed into subgroups according to whether they had seizures during pregnancy or not and whether they used antiepileptic drugs, and first- and second-trimester laboratory parameters were compared between the groups. Furthermore, univariate and multivariate linear regression analysis investigated the relationship between these parameters with the composite adverse neonatal outcomes (CANO). Results: In the study, 72.7% of pregnant women diagnosed with epilepsy were receiving antiepileptic treatment (75.4% monotherapy and 24.6% polytherapy). The incidence of seizures during pregnancy was 38.3%. The epilepsy group exhibited statistically significant differences from the control group in the following areas: gestational age at delivery, preterm birth rate, cesarean section rate, birth weight, neonatal head circumference, APGAR score

show abstract

Effect of antiepileptic drugs on serum biochemical marker levels of first and second trimester screening tests

Cited by 2 publications

References 15 publications

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

Influence of selected factors on serum AFP levels in pregnant women in terms of prenatal screening accuracy — literature review

First and second trimester laboratory changes and perinatal outcomes in pregnant women with epilepsy

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