Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L.

Siahaan, Jekson Martiar

doi:10.26911/theijmed.2017.02.02.02

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…To function as a fuel, food cells, especially glucose, must be metabolised first. In the metabolic process, insulin plays an important role, which is to enter glucose into cells, which can then be used as fuel [15], [16].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Obesity and Lipid Profile in Type 2 Diabetes Mellitus Patients at the Endocrine and Metabolic Polyclinic in General Hospital Pirngadi Medan

Silitonga¹,

Siahaan²,

Anto³

2019

Open Access Maced J Med Sci

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BACKGROUND: Obesity is a multifactorial disease that is dangerous and is a factor in the emergence of serious diseases such as dyslipidemia, stroke, coronary heart disease and others. In Type 2 Diabetes Mellitus (T2DM) patients there is a disorder of lipid metabolism, namely dyslipidemia. Changes in lipid profile that occurred were an increase in total cholesterol levels, Low-Density Lipoprotein (LDL), and triglycerides, and decreased levels of high-density lipoprotein (HDL). The phenomenon of an increase in T2DM patients in Indonesia caused double mortality in recent decades. AIM: This study was to determine the relationship between obesity and lipid profile in T2DM patients at Pirngadi Medan Hospital in 2018. METHODS: This study was conducted in an observational analytic with a cross-sectional study approach. Fifteen obese patients with T2DM who were treated at the Endocrine and Metabolic Polyclinic in Pirngadi General Hospital Medan from January to December 2018 were recruited into the study sample. RESULT: Based on the analysis using the results of a one-way correlative analytical test showing that there was a positive correlation between obesity and total cholesterol levels (r = 0.209; p = 0.455) and LDL levels (r = 0.335; p = 0.222) but not significant. There was a negative correlation between obesity and HDL levels (r = -0.072; p = 0.798) and triglyceride levels (r = -0.025; p = 0.930) but not significant. There was no significant relationship between obesity and blood glucose levels (r = 0.463; p = 0.082). This study concluded that there was no significant relationship between obese patients and lipid profiles in T2DM patients. CONCLUSION: Obesity positively correlates with blood glucose level, but its correlation with a lipid profile is not reliable.

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Section: Discussionmentioning

confidence: 99%

Correlation between Obesity and Lipid Profile in Type 2 Diabetes Mellitus Patients at the Endocrine and Metabolic Polyclinic in General Hospital Pirngadi Medan

Silitonga¹,

Siahaan²,

Anto³

2019

Open Access Maced J Med Sci

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“…Swartz), can decrease the blood sugar level (BSL) and increase the antioxidant level in diabetic mice. There was also a difference in the diameter of the pancreatic β-cell between chayotetreated mice and non-treated mice [11], [12].…”

Section: Introductionmentioning

confidence: 94%

The Effect of Ethanol and Ethyl Acetate Fraction of Chayote fruit (Sechium edule Jacq. Swartz) on the Oxidative Stress and Insulin Resistance of Male White Rat Model Type 2 Diabetes Mellitus

Siahaan

Illyas

Lindarto

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Oxidative stress in type 2 diabetes mellitus (T2D) causes insulin resistance and disordered insulin secretion. Pathomechanisms of T2D consist of dysfunctional pancreatic β-cell and insulin resistance caused by free radical (reactive oxygen species and reactive nitrogen species) that produced from the glucose metabolism pathway. Insulin resistance can be measured using the homeostatic model assessment of insulin resistance (HOMA-IR). Oxidative stress can measure through the activities of malondialdehyde (MDA) and superoxide dismutase (SOD). AIM: This research aims to study the potential of chayote (Sechium edule Jacq. Swartz) to be used as antihyperglycemic in T2D. MATERIALS AND METHODS: This research was conducted with a post-test randomized controlled group design. Eleven groups with four male rats each were used. Normal untreated rats were treated under ad libitum feeding and drinking condition. Meanwhile, the rat models were induced with the combination of 45 mg/kg b.w. streptozotocin, 110 mg/kg b.w. nicotinamide, 40.5 mg/kg b.w. metformin, high-fat diet, and/or chayote extract. The chayote extract was orally administered to the rat in the form of ethanol extract and/or ethyl acetate fraction, with three dosages of 45 mg/kg b.w., 100 mg/kg b.w., and 150 mg/kg b.w. for each extract type. The body weight, glucose level, insulin level, MDA, and SOD activities were measured. The HOMA-IR was used. RESULTS: The lowest body weight of the rat model in week 0 was 145 ± 25.31, founded in Group H that was treated with ethyl acetate fraction of chayote extract (45 mg/kg b.w.). The lowest blood sugar level in the group with 2 h glucose load was 112.5 ± 27.00 on average, found in Group G that was treated with chayote ethanolic extract (150 mg/kg b.w.). The highest SOD in the group treated with chayote extract was 1.27 ± 0.20, founded in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest level of MDA was 0.86 ± 0.70 in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest fasting blood sugar spectrophotometer level was 150.54 ± 17.24 mg/dl in Group K with metformin treatment, followed by 155.16 ± 31.92 mg/dl in Group K treated 45 mg/kg b.w. ethanol treatment. The highest insulin level was 6.14 ± 0.71, founded in Group F that was treated with chayote ethanolic extract 100 mg/kg b.w. The lowest measurement of HOMA-IR was 0.16 ± 0.80 in Group E treated with ethanol extract of chayote 45 mg/kg b.w. CONCLUSION: Ethanol extract and fractionation of chayote work as an antioxidant and anti-insulin resistance.

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“…In other hand, STZ also can caused increasing of Xanthine oxidase which catalysed the formation of superoxide anion. (Siahaan, 2017) ROS can oxidize polyunsaturated fatty acids (PUFAs) of plasma membranes to form malondialdehyde (MDA) compounds (Ayala et al, 2014) which can altered membrane fluidity, increase permeability, cause the loss of membrane integrity, consequently it will decrease the cell viability (Jaggi and Adav, 2015). The increased level of MDA caused of lipid peroxidation is a pathogenesis symptom which has important role for some diseases, such as DM (Suryawanshi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The Role of Sechium edule Fruits Ethanolic Extract in Insulin Production and Malondialdehyde Level in Stz-Induced Diabetic Rat

Lukiati

Nugrahaningsih

Arifah

2019

J.Tropical Biodiversity Biotechnology

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The objectives of this research were to examine the effect of Sechium edule ethanolic extract in insulin and Malondialdehyde (MDA) levels in streptozotocin (STZ) induced diabetic rats. Type 1 diabetic rat were obtained by intraperitonially injected with multiple low dose STZ (MLD-STZ) 20 mg/kgBW for 5 days. The animals were divided into 5 groups: untreated rats in group (K) were considered as negative control, MLD-STZ induced type 1 diabetic rats in group (S) were considered as positive control. In another 3 group (A, B, C) type 1 diabetic rats were orally treated with three doses of S. edule ethanolic extract (14, 28, 42 mg/kg BW) for 7 days. The animals were sacrificed in two days after last treatment, serum were collected for measuring of the insulin concentration by ELISA method. Level of MDA on kidney, liver and pancreas were measured by TBA method. The treatment with S. edule ethanolic extracts unable to increase of insulin yet but the treatment with 42 mg/kg BW of S. edule ethanolic extract showed significantly decreased MDA levels on liver but not significant on kidney and pancreas.

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Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L.

Cited by 5 publications

References 7 publications

Correlation between Obesity and Lipid Profile in Type 2 Diabetes Mellitus Patients at the Endocrine and Metabolic Polyclinic in General Hospital Pirngadi Medan

Correlation between Obesity and Lipid Profile in Type 2 Diabetes Mellitus Patients at the Endocrine and Metabolic Polyclinic in General Hospital Pirngadi Medan

The Effect of Ethanol and Ethyl Acetate Fraction of Chayote fruit (Sechium edule Jacq. Swartz) on the Oxidative Stress and Insulin Resistance of Male White Rat Model Type 2 Diabetes Mellitus

The Role of Sechium edule Fruits Ethanolic Extract in Insulin Production and Malondialdehyde Level in Stz-Induced Diabetic Rat

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