Effect of Antihypertensive Drugs on Homocysteine level among Hypertensive Patients

Rawat, Rahul; Joshi, Yogesh

doi:10.5958/2231-5659.2018.00037.1

Asia. Journ. of Resear. in Pharmac. Scie.

2018

DOI: 10.5958/2231-5659.2018.00037.1

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Effect of Antihypertensive Drugs on Homocysteine level among Hypertensive Patients

Rahul Rawat¹,

Yogesh Joshi²

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Cited by 7 publications

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Effect of Amlodipine in Proliferative Retinopathy: Biochemical Estimation and Zebrafish (Danio rerio) Modeling

Nanda

Aparna

Sahoo

et al. 2022

RJPT

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Proliferative retinopathy is described as a progressive neovascularization in the inner surface of the retina or vitreous, which subsequently threatens vision by causing retinal detachment or vitreous hemorrhage. Reactive oxygen species generation and its related vasoproliferative factor up regulation play a major role in progression of the disease. The present study focuses on Carr induced reactive species generation with its related vasoproliferative factor up regulation and ameliorative activity of AML. Biochemical estimation of catalase, lipid peroxidation, hypoxia inducing factor (HIF-1α) and guanyl-s-transferase (GST) were done. AML treated group showed significant increase in catalase enzyme, guanyl-s-transferase and significantly reduced the lipid peroxidation. Western blotting assay showed a significant decrease in HIF-1α in AML treated group. The progression of PR alters the endogenous cell signalling thus causing havoc in retinal cells. Therefore, it could be hypothesized that use of AML can be a new detection method for therapeutic strategies to prevent blindness in PR.

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Effect of Amlodipine in Proliferative Retinopathy: Biochemical Estimation and Zebrafish (Danio rerio) Modeling

Nanda

Aparna

Sahoo

et al. 2022

RJPT

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Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients

Gburi

Hashim

Kadhim

et al. 2022

RJPT

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The Growth Differentiation Factor -15 (GDF-15) is a member of the transforming growth factor β superfamily. İt represents an example of the stress response cytokines. It's mostly found in cardiac myocytes, adipocytes, macrophages, endothelial cells, and vascular endothelial cells, whether they're generated normally or not. GDF-15 levels have increased and are associated with cardiovascular risk. Aim of the study: To investigate the correlation between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) with the level of plasma GDF-15 in a group of hypertensive patients. Materials and methods: A case-control study involved 90 individuals, 60 hypertensive patients (36 on ACE inhibitors and 24 on ARBs) and 30 healthy individuals. Serum GDF-15 was measured and compared statistically between the two groups. Results: serum GDF-15 was significantly higher in both groups of hypertensive patients compared to the control group. İn addition, there was no significant difference in mean serum GDF-15 concentration between patients treated with ACE inhibitors with those treated with angiotensin II receptor blockers. Conclusion: GDF-15 increases in hypertensive patients and might be a reasonable marker of cardiovascular disease. Both ACE inhibitors and ARBs are not powerful enough to decrease GDF-15 concentration to that of the control group.

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The effect of Hyperhomocysteinemia on the Osteoclasts activity in Male New Zealand White Rabbits

Majid

Jbori

2022

RJPT

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Methionine is a specific amino acid which contains sulfur, and can be used to make proteins, found in fish, meat, and dairy products, the excess intake of L-methionine lead to elevated homocysteine (Hcy) level that known as Hyperhomocysteinemia (HHcy). Increased Hcy plasma may represent an independent risk factor for osteoporotic fractures, and therefore may also negatively affect bone metabolism. This study was designed to examine the impact of Hcy on osteoclast activity in Male Rabbits, following methionine overload. To achieve this study's aims, we recruiting (20) males of New Zealand white rabbits that were divided into (10/group) control group and a group treated with methionine. Then after the intubation of methionine overload, we measured the "Receptor Activator of Nuclear factor Kappa-b" (RANK) and "Receptor Activator of Nuclear factor Kappa-b ligand" (RANK-L) levels in the blood, in addition to histological examination of the trabecular structure of femur bone. The results show a significant (p≤0.001) increase in serum RANK and RANK-L levels of methionine treated group in comparison with the control group. The histological examination of the trabecular structure of femur bone shows an increase in osteoclasts percentage, activity, and large resorption pits in the methionine treated group. The HHcy that was induced by methionine overload, caused an increase in osteoclast activity and numbers in male rabbits suggested a mechanistic role for bone resorption by Hcy. Future research clarifying the mechanistic function of elevated concentrations of Hcy in osteoporosis may have important therapeutic implications.

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Effect of Antihypertensive Drugs on Homocysteine level among Hypertensive Patients

Cited by 7 publications

References 0 publications

Effect of Amlodipine in Proliferative Retinopathy: Biochemical Estimation and Zebrafish (Danio rerio) Modeling

Effect of Amlodipine in Proliferative Retinopathy: Biochemical Estimation and Zebrafish (Danio rerio) Modeling

Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients

The effect of Hyperhomocysteinemia on the Osteoclasts activity in Male New Zealand White Rabbits

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