1969
DOI: 10.3181/00379727-131-33793
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Effect of Antilymphocyte Serum on Parameters of Tumor Growth in a Syngeneic Tumor-Host System

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Cited by 24 publications
(14 citation statements)
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“…On the other hand, the resistance of both weanling and older rats to a primary clhallenge of Y-P388 tumour in muscle was reduced by either WBI or ALS; irradiation did not significantly reduce the secondary response of the host to tumour growth in muscle whereas ALS did so but not completely (unpublished results). The finding reported by Fisher, Soliman and Fisher (1969) that ALS enhanced take, growth and metastasis of mouse mammary tumours in syngeneic C3HB/FeJ hosts is also of interest in this respect. Certain other findings also appear relevant to the mode of action of immunosuppressive agents against growth of syngeneic and allogeneic tumours.…”
Section: Discussionmentioning
confidence: 92%
“…On the other hand, the resistance of both weanling and older rats to a primary clhallenge of Y-P388 tumour in muscle was reduced by either WBI or ALS; irradiation did not significantly reduce the secondary response of the host to tumour growth in muscle whereas ALS did so but not completely (unpublished results). The finding reported by Fisher, Soliman and Fisher (1969) that ALS enhanced take, growth and metastasis of mouse mammary tumours in syngeneic C3HB/FeJ hosts is also of interest in this respect. Certain other findings also appear relevant to the mode of action of immunosuppressive agents against growth of syngeneic and allogeneic tumours.…”
Section: Discussionmentioning
confidence: 92%
“…More recently, such tests have been extended to include syngeneic tumour-bearing animals, challenged intravenously (IV) (Vaage, 1973; Proctor et al, 1973a;Milas et al, 1974;Proctor et al, 1974), and such studies have demonstrated that specific immunological factors may influence metastatic spread. Further support for this concept is provided by reports of increased spontaneous blood-borne metastatic spread, following immunosuppressive procedures in syngeneic animal models (Fisher et al, 1969; Proctor et al, 1973a), and either an increase or a decrease in such spread following specific active immunotherapeutic measures (Vanwijk et al, 1971 ;Godrick et al, 1972; Proctor et al, 19736).However, as has been emphasized recently by Weiss et al (1974), relatively little attention has been paid to the influence of specific immune anti-turnour mechanisms on the initial localization and fate of blood-borne tumour cells in the target organ, prior to the establishment of metastases. These authors demonstrated that a high proportion of radiolabelled tumour cells was localized in the lungs of normal, tumour-bearing and hyperimmune mice 1 h after injection and that there was significantly less radioactivity in the lungs of the tumour-bearing and hyperimmune animals than in those of normal controls.…”
mentioning
confidence: 99%
“…The influence of immunologic factors on the formation of metastases has also been described. Treatment with heterologous antilymphocyte serum (ALS) has increased metastasis formation in allogeneic systems (Hellman et al, 1968;Deodhar and Crile, 1969;Gershon and Carter, 1970) and in syngeneic systems (Fisher et al, 1969). Crile and Deodhar (1971) demonstrated significant protection against metastasis formation from Sarcoma 241 in C57BL mice which were specifically immunized against the tumour.…”
mentioning
confidence: 99%