Effect of Antioxidant Activity and Induction of DNA Damage on Human Gastric Cancer Cell by Rubus coreanus Miquel

Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression

“…[6][7][8][9] These RCM constituents have been shown to exert diverse functional effects, including anti-osteoporosis, anti-inflammation, and anti-carcinogenesis. 10,11) Anti-carcinogenic functions of RCM are suggested to act partly by inducing DNA damage, 12) activating apoptosis, 13) and reducing angiogenesis. 14) Sanguiin H-6 extracted from RCM has been shown to decrease angiogenesis in endothelial cells via the inhibition of vascular endothelial growth factor receptor-ligand binding.…”

Ethanolic extract from Rubus coreanus enhanced swimming capacity in mice

“…Bokbunja fruits contain antioxidants, including anthocyanins, epicatechin, ellagic acid, and ferulic acid, and high levels of sugars, organic acids, and vitamins. Some studies have indicated the efficacy of the fruit as anti-rheumatism, anti-oxidant, and anti-cancer agents (17). In a previous study, ethanol extract of freeze-dried Rubus coreanus fruit were implicated in relief of fatigue caused by 3 days of exhaustive swimming exercise based on enhancement of antioxidant enzyme activities (18).…”

Anti-inflammatory effect of a standardized triterpenoid-rich fraction isolated from Rubus coreanus on dextran sodium sulfate-induced acute colitis in mice and LPS-induced macrophages

“…Rubus coreanus has traditionally been used as a remedy for prostate and liver diseases and inflammatory diseases, such as diarrhea, asthma, allergy, and stomach ailment, and also for the prevention of uterine, cervical, and colon cancer (Hummer, 2010;Kim et al, 2012b;Chae et al, 2014). Furthermore, Rubus coreanus are recently reported to have anti-cancer, anti-inflammatory , anti-bacterial (Oh et al, 2012), and anti-oxidant functions (Jeon et al, 2007). Scientists have tried to elucidate the active components in Rubus coreanus and found that it contains various flavonoids, anthocyanins, polyphenols (Lim et al, 2012a(Lim et al, , 2012b and triterpenoids (niga-ichigoside F1 and its aglycone 23-hydroxytormentic acid) (Choi et al, 2003).…”