Effect of Antioxidant Mineral Elements Supplementation in the Treatment of Hypertension in Albino Rats

Abstract

<jats:p>Oxidative stress has been implicated in various pathologies, including hypertension, atherosclerosis, diabetes, and chronic renal disease. The current work was designed with the aim of investigating the potentials of antioxidants copper, manganese, and zinc in the treatment of hypertension in Wistar rats. The rats were fed 8% NaCl diet for 5 weeks and treatment with supplements in the presence of the challenging agent for additional 4 weeks. The supplementation significantly decreased the blood pressure as compared with hypertensive control. The result also indicated significant decreased in the levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol, malondialdehyde, insulin and increase in the high-density lipoprotein cholesterol, total antioxidant activities, and nitric oxide of the supplemented groups relative to the hypertensive control. The average percentage protection against atherogenesis indicated 47.13 ± 9.60% for all the supplemented groups. The mean arterial blood pressure showed significant positive correlation with glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, insulin resistance and malondialdehyde while high density lipoprotein-cholesterol and total antioxidant activities showed negative correlation. The result therefore indicated strong relationship between oxidative stress and hypertension and underscores the role of antioxidant minerals in reducing oxidative stress, dyslipidemia, and insulin resistance associated with hypertension.</jats:p>

Polish Journal of Veterinary Sciences

“…In our experiment, the increase in plasma TAG concentration could have resulted from a higher Cu:Zn ratio in blood plasma. Hypercholesterolemia induced by Zn deficiency due to higher dietary intake of Cu was reported in a study of rats (Muhammad et al 2012). In our experiment, plasma TP concentration increased with a rise in the dietary inclusion levels of Cu.…”

Effect of customized mineral supplement on blood biochemical profile, antioxidant indices and immunity in kids

“…Our results are in conformity with the finding of Jing et al (2007), who fed rats on different Zn levels for 6 weeks and reported that rats fed on Zn deficient diet had reduced activities of copper-zinc superoxide dismutase (Cu-Zn SOD) and CAT; and increased malondialdehyde as well as hydrogen peroxide concentrations in liver. Similarly, Muhammad (2012) found that supplementation of antioxidant minerals to the albino rats increased the activities of CAT, Gpx, and SOD as compared with hypertensive control. Nevertheless, CAT activity in the present study was comparable among treatment groups.…”

Evaluation of Body Weight, Serum Lipid Profile, Glucose Homeostasis, Oxidative Stress and Hepatic Function in Healthy Mice Fed With Zinc Sulphate Supplementation

“…Similar to our study, Atakisi et al 24 observed that treatment with zinc on quills raised the NO level in the body. Muhammad et al 41 also showed that the administration of zinc improved endothelial function by increasing the NO level when compared with hypertensive control rats. In our study, zinc is decreasing the oxidative stress by attenuating lipid peroxidation and increasing the non-enzymatic antioxidant.…”