Effect of antioxidant supplementation on skeletal muscle and metabolic profile in aging mice

Tsukamoto-Sen, Sakuka; Kawakami, S.; Maruki‐Uchida, Hiroko; Ito, Ryouichi; Matsui, Naoko; Komiya, Yuki; Mita, Yoshitaka; Morisasa, Mizuki; Goto‐Inoue, Naoko; Furuichi, Yukio; Manabe, Yasuko; Morita, Minoru; Fujii, Nobuharu

doi:10.1039/d0fo02051f

Cited by 17 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are highly relevant for elderly and frail individuals or people who often experience inflammation and loss of muscle quality. Additionally, studies have confirmed that an increase in the intake of components with antioxidant and anti-inflammatory properties from diet or from supplementation could effectively prevent the negative impact of antioxidant deficiency, including oxidative status, lower muscle strength and muscle fatigue after an exercise challenge [ 14 , 21 , 45 , 46 , 47 ]. As typical bioactive peptides, WOPs have been shown to have great anti-inflammatory and antioxidative biological activities [ 24 , 25 , 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

Fan

Hao

et al. 2022

Nutrients

View full text Add to dashboard Cite

Aging-related muscle loss is a hallmark of aging and is the cause of some negative outcomes. An optimized diet and supplements have a positive effect in slowing down the process of muscle loss. This study was designed to evaluate the beneficial effects of walnut oligopeptides (WOPs) on aging-related muscle loss and explore the possible underlying mechanism in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice. SAMP8 mice were randomly divided into four groups (n = 15/group), including one group which was the SAMP8 age control group and three groups those were WOP intervention groups. Meanwhile, Senescence Accelerated Resistant Mouse 1 (SAMR1) mice (n = 12), which had normal senescence rates, were used as model controls. During the six-month intervention period, the age control and normal control groups were given sterilized water, while the three WOP intervention groups were given WOP solution with low (110 mg/kg·bw), medium (220 mg/kg·bw) and high concentrations (440 mg/kg·bw), respectively. The results showed that WOPs could significantly increase muscle mass and improve physical performance (wire hang and catwalk behavioral tests) in aging mice. Moreover, WOPs could significantly reduce the levels of IL-1β, IL-6 and TNF-α in serum and gastrocnemius tissues and increase the mitochondrial DNA content, as well as the expression levels of AMPK, PGC-1α, NRF-1 and TFAM in the gastrocnemius muscle of aging mice, which was speculated to be the specific mechanism related to mitochondrial function improvement and inflammation reduction. These results indicate that WOPs can improve aging-related muscle loss, in term of both muscle mass and physical performance, and WOP supplements seems to be potentially effective in elderly individuals.

show abstract

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

Fan

Hao

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“…Sarcopenic patients are susceptible to loss of strength due to muscle fibre loss caused by overproduction of reactive oxygen species and pro-inflammatory mediators, immune senescence, and anabolic resistance status [ 64 , 65 , 66 , 67 ]. The main treatments for sarcopenia are nutritional therapies aimed at achieving a caloric intake of 24–36 kcal/kg body weight/day and a protein intake of 1.0–1.5 g/kg body weight/day [ 68 , 69 ] and supplementation with antioxidants [ 70 ], protein and essential amino acids (EAA) [ 71 ], omega-3 fatty acids, and creatine monohydrate [ 72 ].…”

Section: Musclesmentioning

confidence: 99%

Probiotics in Orthopedics: From Preclinical Studies to Current Applications and Future Perspective

Mazzotti,

Langone,

Arceri

et al. 2023

Microorganisms

View full text Add to dashboard Cite

In recent years, probiotics have been emerging as an attractive therapeutic strategy for several diseases. In orthopedics, probiotics seem to be a promising supplementation for treatment of osteoporosis, osteoarthritis, muscle loss-related disease, wound and ulcer issues, and prevention of surgical antibiotic prophylaxis side effects. Although probiotics are still not included in guidelines for these conditions, several studies have reported theoretical benefits of their administration. Further high-level clinical trials are necessary to convert research into solid clinical practice. However, probiotics represent a cost-effective future perspective and may play a role in association with traditional orthopedic therapies.

show abstract

“…As muscle is a critical organ in regulating the metabolism of the whole body, a metabolic profile under sitting and exercise conditions was also determined. Chronic administration of EMIQ prevented the age-related decrease in lipid oxidation and slightly improved the antioxidant capacity and oxidative stress in skeletal muscle, increasing the expression of genes for the antioxidant enzyme glutathione peroxidase and reducing the level of carbonyl proteins [ 66 ].…”

Section: Bioactivitymentioning

confidence: 99%

Enzymatically Modified Isoquercitrin: Production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms

Owczarek

Magiera

Olszewska

2022

IJMS

View full text Add to dashboard Cite

Quercetin and its glycosides, such as isoquercitrin or rutin, are among the most ubiquitous flavonoids present in plants. They possess numerous health-promoting properties, whose applicability is, however, limited by poor water solubility and absorption issues. Enzymatically modified isoquercitrin (EMIQ) is an isoquercitrin derivative obtained from rutin via enzymatic transformations that greatly enhance its bioavailability. Due to advantageous reports on its safety and bioactivity, EMIQ is currently gaining importance as a food additive and a constituent of dietary supplements. This review summarizes the thus-far-conducted investigations into the metabolism, toxicity, biological properties, and molecular mechanisms of EMIQ and presents a comprehensive characterization of this valuable substance, which might represent the future of flavonoid supplementation.

show abstract

Effect of antioxidant supplementation on skeletal muscle and metabolic profile in aging mice

Abstract: Chronic antioxidant (piceatannol or enzymatically modified isoquercitrin) supplementation improved metabolic profile and locomotor activity in aging mice.

Cited by 17 publications

References 43 publications

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

Beneficial Effects of Walnut Oligopeptides on Muscle Loss in Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Focusing on Mitochondrial Function

Probiotics in Orthopedics: From Preclinical Studies to Current Applications and Future Perspective

Enzymatically Modified Isoquercitrin: Production, Metabolism, Bioavailability, Toxicity, Pharmacology, and Related Molecular Mechanisms

Contact Info

Product

Resources

About