Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

Wang, Yuan‐Yuan; Hodge, Allison; Wluka, Anita E.; English, Dallas R.; Giles, Graham G.; O’Sullivan, Richard; Forbes, Andrew Benjamin; Cicuttini, Flavia Maria

doi:10.1186/ar2225

Cited by 75 publications

(60 citation statements)

References 26 publications

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“…These findings are supported by a cross-sectional study conducted in 2007, examining the effect of antioxidant intake on knee cartilage and bone in healthy individuals (n 293) (17) . Antioxidant intake was estimated from a baseline FFQ.…”

Section: Discussionsupporting

confidence: 62%

“…MRI of the knee was taken at baseline and again at 10 years. Wang et al (17) found vitamin C intake to be associated with a 50 % risk reduction of bone marrow lesions (OR 5 0?50, 95 % CI 0?29, 0?87, P 5 0?01) and inversely associated with tibial plateau bone area (b 5 235?5 %, 95 % CI 5 268?8, 22?3, P 5 0?04), both of which are involved in the pathogenesis of knee OA. Increased vitamin C intake has also been shown to exhibit a slight chondroprotective effect (P 5 0?08) on the development of spontaneous lesions in guinea pigs, with no such effect on the progression of surgically induced OA (18) .…”

Section: Discussionmentioning

confidence: 99%

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The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

Peregoy

Wilder

2010

Public Health Nutr.

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Objective: To evaluate the association between vitamin C supplementation and the incidence and progression of radiographic knee osteoarthritis (OA). Design: Prospective cohort study. Setting: Clearwater Osteoarthritis Study (COS): (1988 to the present) a longitudinal study. Subjects: Male and female COS participants aged 40 years and above (n 1023). The study exposure was the participants' self-reported history of vitamin C supplementation. The participants underwent biennial, sequential knee radiographs, which were assessed using the Kellgren-Lawrence ordinal scale to determine evidence of the study 2 outcomes: incident radiographic knee OA (RKOA) and progression of RKOA. Results: Individuals without baseline knee OA who self-reported vitamin C supplement usage were 11 % less likely to develop knee OA than were those individuals who self-reported no vitamin C supplement usage (risk ratio (RR) 5 0?89, 95 % CI 0?85, 0?93). Among those participants with RKOA at baseline, vitamin C supplement usage did not demonstrate an association with RKOA progression (RR 5 0?94, 95 % CI

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

Peregoy

Wilder

2010

Public Health Nutr.

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“…[52][53][54] The effect of dietary antioxidants on knee structure in a cohort of healthy, middle-aged subjects with no clinical knee osteoarthritis is examined. 52) Two hundred and ninety-three healthy adults (mean age = 58.0 years) without knee pain or knee injury are selected from an existing community-based cohort. The intake of antioxidant vitamins and food sources by these individuals was estimated from a food frequency questionnaire at baseline.…”

Section: Epidemiological Evidence For Role Of β-Cryptoxanthin In Bonementioning

confidence: 99%

.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

Yamaguchi

2008

JOURNAL OF HEALTH SCIENCE

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Bone loss with aging induces osteoporosis. The most dramatic expression of the disease is represented by fractures of the proximal femur. Pharmacologic and nutritional factors may play a role in the prevention of bone loss with aging. β-Cryptoxanthin, a kind of carotenoid, is abundant in Satsuma mandarin orange (Citrus unshiu MARC.). Amoung various carotenoids including β-cryptoxanthin, lutein, lycopene, β-carotene, astaxanthin, and rutin, β-cryptoxanthin has been found to have a unique anabolic effect on bone calcification in vitro. Hesperidin, which is contained in Satsuma mandarin orange, did not have an anabolic effect on bone calcification in vitro. β-Cryptoxanthin has stimulatory effects on osteoblastic bone formation and inhibitory effects on osteoclastic bone resorption in vitro, thereby increasing bone mass. β-Cryptoxanthin has an effect on the gene expression of various proteins which are related to osteoblastic bone formation and mineralization in vitro. β-Cryptoxanthin has inhibitory effects on enzyme activity which is related to osteoclastic bone resororption, and the carotenoid induces apoptosis of mature osteoclastic cells in vitro. Oral administration of β-cryptoxanthin has been shown to have the anabolic effects on bone components in young and aged rats, and the administration has the preventive effects on bone loss in streptozotocin-diabetic rats and ovariectomized rats in vivo. Moreover, the intake of β-cryptoxanthin-reinforced juice for longer periods has been shown to have both stimulatory effects on bone formation and inhibitory effects on bone resorption in healthy human or postmenopausal women in evaluating with serum biochemical markers of bone metabolism in vivo. Thus the intake of dietary β-cryptoxanthin may have a preventive effect on osteoporosis due to stimulating bone formation and due to inhibiting bone resorption. Moreover, epidemiological studies suggest the potential role of β-cryptoxanthin as a sustainable nutritional approach to improving bone health of human subjects. β-Cryptoxanthin is an important food factor in maintaining bone healthy and in preventing osteoporosis.

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“…Epidemiological studies have further suggested that ß-cryptoxanthin constitutes a sustainable nutritional approach to improving the bone health of human subjects (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts

Yamaguchi¹

2009

Int J Mol Med

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Abstract. The xanthophyll ß-cryptoxanthin is a member of the carotenoid family of plant-derived pigments endowed with anti-osteoporotic properties in vivo. ß-cryptoxanthin was demonstrated to stimulate osteoblastic bone formation and simultaneously repress osteoclastic bone resorption in vitro. However, the mechanisms of action remain to be elucidated. The SMAD signal transduction pathway is established to play a critical role in osteoblast lineage commitment and differentiation. In this study we used transient transfection assays of a SMAD luciferase reporter to investigate whether ß-cryptoxanthin regulates SMAD activation in MC3T3 preosteoblastic cells. ß-cryptoxanthin did not stimulate basal SMAD activity but amplified transforming growth factor (TGF)-ß1-induced SMAD activation. Interestingly, ß-cryptoxanthin did not affect bone morphogenetic protein-2 (BMP-2)-induced SMAD activation in osteoblastic cells, suggesting specificity of action on the TGF-ß1 pathway. This study suggests that the carotenoid ß-cryptoxanthin may promote osteoblast differentiation and activity by amplifying TGF-ß1-induced lineage commitment of osteoblast precursors.

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Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study

Cited by 75 publications

References 26 publications

The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study

.BETA.-Cryptoxanthin and Bone Metabolism: The Preventive Role in Osteoporosis

The bone anabolic carotenoid β-cryptoxanthin enhances transforming growth factor-β1-induced SMAD activation in MC3T3 preosteoblasts

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