Effect of antiserotonin antibodies on pain sensitivity in rats with adjuvant-induced arthritis

Abstract

Active immunization with a serotonin--protein conjugate inducing the formation of antiserotonin antibodies exerts an analgesic effect in rats with adjuvant-induced arthritis and inhibits the development of arthritis in early stages after injection of Freund's complete adjuvant.

Correction of Adjuvant Arthritis with Delphinium Extracts and Alkaloids

“…Hyperalgesia was evaluated on days 9, 12, and 14 of the experiment by the number of vocalizations during passive fl exion of the infl amed joint [1]. Vocalization index was calculated by the formula: V=(N/5)×100%, where N was the number of vocalizations.…”