Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: Evidence for dopaminergic supersensitivity in protracted abstinence

Gianutsos, Gerald; Hynes, Martin D.; Puri, Surendra K.; Drawbaugh, Richard B.; Lal, Harbans

doi:10.1007/bf00421218

Cited by 114 publications

(25 citation statements)

References 17 publications

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“…Part of this work was presented by invitation at the Symposium on 'Interaction of drugs of abuse', promoted by the National Institute of Drug Abuse, held at the New York Academy of Sciences, 1976. morphine administration (6,10,15), behavioral changes observed after discontinuation of chronic neuroleptic administration (8,9,25), and after the destruction of brain catechol amine systems (16,26,27). These authors support their claims by comparing the effects of apomorphine and other agonists of dopamine receptors in experimental and con trol animals.…”

mentioning

confidence: 99%

Does REM Sleep Deprivation Induce a Supersensitivity of Dopaminergic Receptors in the Rat Brain?

Tufik

Lindsey

Carlini³

1978

Pharmacology

197

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The possibility that REM sleep deprivation induces increased sensitivity of rats to the effects of apomorphine was investigated. Rats were deprived of REM sleep by placing them on 6.0 cm platforms for 3 days. Stress control groups consisting of rats placed on 14 cm platforms (control rats) and groups of nonmanipulated animals (normal rats) were used for comparison purposes. Several doses of apomorphine were administered to these 3 groups of animals, and aggressive behavior, stereotyped behavior, verticalization and body temperature were recorded. All measures indicated that REM-deprived rats were more responsive to apomorphine than the normal and control animals, with the exception of verticalization effect, in which both REM-deprived and control animals reacted similarly. These results suggest that REM deprivation induced supersensitivity in brain dopamine receptors. Other possible interpretations are also discussed.

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mentioning

confidence: 99%

Does REM Sleep Deprivation Induce a Supersensitivity of Dopaminergic Receptors in the Rat Brain?

Tufik

Lindsey

Carlini³

1978

Pharmacology

197

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“…Much of the work has been done with brain acetylcholine and dopamine receptors. Both behavioural and biochemical evidence suggest that supersensitivity of dopamine and acetylcholine receptors develops with chronic morphine treatment (Puri & Lal, 1973;Gianutsos, Hynes, Puri, Drawbaugh & Lal, 1974;Iwatsubo & Clouet, 1975). However, conflicting reports also exist, indicating lack of effect on dopamine stimulated adenylate cyclase (Kushinsky, 1975) and decreased dopamine receptor binding (Puri, Spaulding & Mantione, 1978) after chronic morphine treatment.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Melanotrophin Release Inhibiting Factor (Mif) and Cyclo (Leu‐gly) on the Tolerance to Morphine‐induced Antinociception in the Rat: A Dose‐response Study

Bhargava

1981

British J Pharmacology

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I The effects of melanotrophin release inhibiting factor (MIF) and its cyclic analogue cyclo (Leu-Gly) on tolerance to the analgesic effect of morphine were studied in male Sprague-Dawley rats.2 Tolerance to morphine was induced by implantation of four morphine pellets (each containing 75 mg of morphine free base) during a 3 day period. 3 Daily subcutaneous administration of MIF and cyclo (Leu-Gly) before and during the morphine pellet implantation inhibited the development of tolerance to morphine analgesia. The minimum daily dose of the peptides required to produce a significant effect was 0.5 mg/kg. 4 The effects of single injections of MIF and cyclo (Leu-Gly) on morphine tolerance revealed that the minimum doses of cyclo (Leu-Gly) and MIF to inhibit morphine tolerance were 4 and 8 mg/kg, respectively.5 Chronic treatment with morphine resulted in an enhanced hypothermic response to a dopamine agonist, apomorphine. The enhancement of this response was blocked by both MIF and cyclo (Leu-Gly) in doses that inhibited morphine tolerance. 6 It is concluded that MIF and cyclo (Leu-Gly) block the development of analgesic tolerance as well as dopamine receptor hypersensitivity induced by chronic morphine treatment and the two phenomena may be interrelated.

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“…Similarly, cannabis induces aggressive behaviour in 6-hydroxydopamine (6-OHDA) pretreated rats (Musty et al, 1976) and in morphine-abstinent rats (Carlini & Gonzalez, 1972). Opiate (Gianutsos, Hynes, Puri, Drawbaugh & Lal, 1974) and 6-OHDA (Barnes, Cann, Karczmar, Kindel & Longo, 1973) (Kramer & Ben David, 1974) and induction of turning behaviour (Waters & Glick, 1973;Hine, Friedman, Torrelio & Gershon, 1975) serve as examples. A question that may be asked is, if the changes that were observed in response to nomifensine and A9-THC or marihuana are due to REM sleep-deprivation per se or to the stress derived from the deprivation procedure.…”

Section: Discussionmentioning

confidence: 99%

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

Carlini

Lindsey

Tufik

1977

British J Pharmacology

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1Previous work from our laboratory has shown that cannabis induces aggressive behaviour in rats that have been deprived of rapid eye movement (REM) sleep. It was suggested that this effect was related to brain catecholamines, with dopamine playing an agonist role and noradrenaline an inhibitory one. The present paper describes new experiments dealing with this subject. 2 Previous REM sleep-deprivation enhanced both A9-tetrahydrocannabinol (THC)-induced hypothermia and nomifensine effects on aggressive behaviour. 3 A marihuana extract decreased brain dopamine turnover in REM sleep-deprived rats, an effect not observed in non-deprived rats. Noradrenaline metabolism was not altered. 4 Fighting behaviour was elicited in REM sleep-deprived rats treated with 4 different dopamine-,6-hydroxylase inhibitors. 5 Apomorphine, nomifensine and A9-THC administered to non-deprived rats pretreated with bis(4-methyl-l-homopiperanzinyl-thiocarbonyl) disulphide (Fla-63), induced fighting behaviour. 6 Nomifensine and apomorphine induced fighting in non-deprived rats pretreated with A9-THC. 7 Clonidine inhibited the fighting elicited in REM sleep-deprived rats by either A9-THC or 8 The data are discussed in terms of the influence of REM sleep-deprivation (or the stress associated with deprivation) on the response to dopaminergic drugs and cannabis. Taken together they emphasize the participation of brain dopamine and noradrenaline systems in the aggressive behaviour studied.

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Effect of apomorphine and nigrostriatal lesions on aggression and striatal dopamine turnover during morphine withdrawal: Evidence for dopaminergic supersensitivity in protracted abstinence

Cited by 114 publications

References 17 publications

Does REM Sleep Deprivation Induce a Supersensitivity of Dopaminergic Receptors in the Rat Brain?

Does REM Sleep Deprivation Induce a Supersensitivity of Dopaminergic Receptors in the Rat Brain?

The Effect of Melanotrophin Release Inhibiting Factor (Mif) and Cyclo (Leu‐gly) on the Tolerance to Morphine‐induced Antinociception in the Rat: A Dose‐response Study

Cannabis, Catecholamines, Rapid Eye Movement Sleep and Aggressive Behaviour

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