Effect of applying modes of the polymer microneedle-roller on the permeation ofl-ascorbic acid in rats

Abstract

Despite the advantages of drug delivery through skin, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept known as microneedle was introduced and could be used to pierce effectively to deliver drugs using micron-sized needles in a minimally invasive and painless manner. In this study, the polymer microneedle-roller was fabricated so that it can be applied into the permeation of L-ascorbic acid. Moreover, a recent publication suggested the possibility of ascorbic acid 2-phosphate as a hair restorer; hence, this study was carried out to check the effect of L-ascorbic acid itself on the hair growing rate in rats according to the presence of various application frequencies of the polymer microneedle-roller. When the polymer microneedle-roller was applied nine times with four directions into rat's shaved skin, the permeation of L-ascorbic acid increased by 10.54-fold compared to that of the absence of the polymer microneedle-roller. The histological examination revealed that the skin pretreated with various application frequencies of the polymer microneedle-roller had more transport pathways. The faster hair growing phenomenon was observed in the presence of polymer microneedle-roller compared to the absence of the polymer microneedle-roller.

Assessment of solid microneedle rollers to enhance transmembrane delivery of doxycycline and inhibition of MMP activity

“…The extent of membrane disruption by manual rolling may be dependent on the number of rolls as well as the number of planes in which the microneedles are rolled in. In this study, the microneedles were rolled unilaterally without removal of the microneedles from the membrane; however, other studies have used multilateral rolling which creates overlapping micropores (Badran et al, 2009;You et al, 2010;Zhou et al, 2010). This suggests that for 'poke and patch' IDD and TDD, rolling is a more efficient way of permeabilizing skin than static impact insertion of the microneedle system, and that repeated rolls increase drug diffusion rates .…”

Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin

“…[1][2][3][4][5] The feasibility of microneedle-mediated delivery of nanoparticles into or through the skin has also been confirmed. 6,7 Initially, McAllister et al reported permeation of latex nanoparticles of up to 100 nm through human cadaver epidermis after the skin was treated with solid microneedles (150 µm long, base diameter 80 µm).…”

Microneedles: an emerging transdermal drug delivery system

“…Desmopressin [70] Coat and poke Efficient, controlled and less variable delivery of desmopressin was achieved. Drugs L-Ascorbic acid [34] Poke and release Faster hair growth due to 10.54 fold increased in penetration. Galanthamine [71] Poke and patch Enhanced drug delivery.…”

“…Reproduced with permission from Elsevier. [8] [26] Polylactic acid (PLA) [27] Polyvinyl acetate (PVA) [18] Thermoplastic starch [28] Stainless steel [29] Polyglycolic acid (PGA) [27] Alginic acid [18] Carboxymethylcellulose [30] Titanium 19 Polylactide-co-glycolic acid (PLGA) [27] Gantrez AN-139, a copolymer of methylvinylether and maleic anhydride (PMVE/MA) [18] Amylopectin [30] Mesoporous silicon [31] Polycarbonate [16] Carbopol 971 P-NF 18 Dextran, galactose, chondroitin sulfate [32] Polyvinylpyrrolidone (PVP) [33] Polyetherimide [34] Maltose [35] Microneedles: an emerging drug delivery Shital H. Bariya et al…”

“…[12,47] On the other hand You et al reported that penetration of l-ascorbic acid was not significantly increased through microneedle-treated skin as compared with untreated skin. [34] They punctured the skin more than once to demonstrate the effect of application frequency of microneedles.…”