Effect of aqueous ethanol extract of Dialium guineense leaf on diclofenac-induced oxidative stress and hepatorenal injuries in Wistar rats

Ogbe, Raphael John; Luka, Carrol Domkat; Adoga, Godwin I.

doi:10.1007/s00580-018-2822-2

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…We also reported a considerable augmentation in GPT and GOT contents, two important biochemical markers indicating hepatocellular and renal damages [ 34 ], in those rats which were exposed to the single-agent of DIC. This finding was in agreement with the results reported previously [ 37 , 38 ]. Of note, our results suggested that CAR could effectively reduce DIC-mediated elevation of GPT and GOT in rats.…”

Section: Discussionsupporting

confidence: 94%

“…The amount of Malondialdehyde (MDA) is an indicator of lipid peroxidation (LPO), which shows the activation of oxidative stress within the cells [ 41 ]. In this study, the amount of MDA was considerably augmented in the DIC-treated rats, which was in accordance with the results of the earlier researches [ 34 , 38 ]. Furthermore, treatment with CAR after exposure to DIC not only caused a rise in FRAP level but also caused a decline in MDA content in the renal tissues and sera.…”

Section: Discussionsupporting

confidence: 93%

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Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Nouri

Izak-Shirian

Fanaei

et al. 2021

Heliyon

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Nouri

Izak-Shirian

Fanaei

et al. 2021

Heliyon

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“…Previous studies also reported diclofenacinduced toxicity to these organs. [31][32][33][34][35] However, administration or coadministration of resveratrol normalized these adverse impacts of the abovementioned irregularities, demonstrating resveratrol's ability to counter tissue damage caused by diclofenac.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Elbaz

Ahmed

Abdelmonem

2022

J Biochem & Molecular Tox

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Despite the extensive therapeutic uses of diclofenac, it may cause several adverse effects, including hepatorenal injury. The antioxidant and anti-inflammatory properties of resveratrol, a polyphenolic compound, make the agent effective in ameliorating a variety of drug-induced injuries. This study investigated the potential beneficial effects of resveratrol on diclofenac-induced hepatorenal toxicity and explored the role of miR-144 and its relationship to oxidative stress and inflammation triggered by diclofenac. Rats were divided into four groups: control; diclofenac group received diclofenac (10 mg/kg/day, intraperitoneal [ip]) for 7 days; prevention group received resveratrol concomitantly with diclofenac for 7 days; and the treatment group received diclofenac for 7 days followed by resveratrol (20 mg/kg/day, per oral) for another 7 days. Diclofenac administration induced a significant increase in serum hepatorenal biomarkers and histopathological aberrations. In addition, diclofenac upregulated miR-144 while reducing nuclear factor erythroid 2-related factor 2 (Nrf2) protein levels and glutathione (GSH) content.Moreover, diclofenac induced tissue inflammation and apoptosis as evidenced by increased protein expression of nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), and caspase-3. Intriguingly, resveratrol prevention or treatment significantly mitigated the toxic effects of diclofenac as manifested by normalization of the hepatorenal functions and amelioration of the histopathological changes.Resveratrol also triggered miR-144 downregulation with Nrf2 upregulation.Consequently, resveratrol showed hepatorenal antioxidant, anti-inflammatory, and antiapoptotic activities as manifested by improvement in the antioxidant markers along with a decline in NF-κB, TNF-α, and caspase-3 expressions. In conclusion, this study demonstrates a potential therapeutic role of resveratrol in mitigating diclofenac-induced hepatorenal insult, possibly via modulating miR-144/Nrf2/ GSH axis.

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“…Considering DPPH• assay results, all the fruits had very close activities that ranged from 0.81 ± 0.02 for DE to 0.97 ± 0.01 µmol TE/g for DG. Other study correlated antioxidant activities of DG leave extract to its protective effect against induced oxidative stress and hepatorenal injuries (Ogbe, Luka & Adoga, 2019).…”

Section: In Vitro Antioxidant Activitiesmentioning

confidence: 99%

“…There is an overwhelming upsurge in demand for natural food and other nutritionally driven quest in recent time. However, nutritional and health-related information on D. guineense includes antimicrobial properties of its extract (Okeke, Udeani, & Onyebuchi, 2016), partial prevention of drug-induced oxidative stress and anti-plasmodial effects (Ogbe et al, 2019). In addition to a rich source of vitamin C, fibres, sugars, acids, polysaccharides, small amount of protein, lipids, D. guineense possess some plant secondary metabolites that are probably responsible for most of the nutraceutical properties associated with the consumption of the fruit.…”

Section: Introductionmentioning

confidence: 99%

Exploring in Vitro Antioxidant Activity and Physicochemical Properties of Selected Under-Exploited Tropical Fruits

Jolayemi

Olanrewaju

Ogunwale

2020

Acta Universitatis Cibiniensis. Series E: Food Technology

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Dacryodes edulis (DE), Dalium guineensis (DG), Spondias mombin (SM) and Irvingia gabonensis (IG) as notable underexploited tropical wild fruits in Nigeria, were evaluated for quality characteristics, phenolic contents and in-vitro antioxidant activity. pH of the fruits ranked thus DE > IG > DG > SM and the reverse order was true for acidity. IG exhibited highest obrix, vitamin C and total sugar content. DE had no detectable reducing sugar compared to 18.84% in IG. Total phenol and flavonoid contents followed the same pattern with DG as the highest (1796.89 ± 71.1 and 860.64 ± 3.7 mg/100g) and IG as the lowest (454.23 ± 13.9 and 304.98 ± 7.5 mg/100g), respectively. Regarding antioxidant activities, SM was significant for ABTS•, DE and IG were similar in FRAP assay, while all the fruits were effective DPPH• radical scavengers. Generally, the fruits demonstrate high food application potentials with possible health benefits if consumed adequately.

show abstract

Effect of aqueous ethanol extract of Dialium guineense leaf on diclofenac-induced oxidative stress and hepatorenal injuries in Wistar rats

Cited by 13 publications

References 43 publications

Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Carvacrol exerts nephroprotective effect in rat model of diclofenac-induced renal injury through regulation of oxidative stress and suppression of inflammatory response

Resveratrol mitigates diclofenac‐induced hepatorenal toxicity in rats via modulation of miR‐144/Nrf2/GSH axis

Exploring in Vitro Antioxidant Activity and Physicochemical Properties of Selected Under-Exploited Tropical Fruits

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