Effect of aqueous extract and anthocyanins of calyces of <i>Hibiscus sabdariffa</i> (Malvaceae) in rats with adenine-induced chronic kidney disease

Ali, Badreldin H.; Cahlíková, Lucie; Opletal, Lubomı́r; Karaca, Turan; Manoj, P; Ramkumar, Aishwarya; Suleimani, Yousuf M. Al; Za’abi, Mohammed Al; Chocholousova-Havlikova, Lucie; Ločárek, Miroslav; Siatka, T; Blunden, Gerald

doi:10.1111/jphp.12748

Cited by 42 publications

(27 citation statements)

References 46 publications

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“…However, using an adenine-induced CKD model in rats recently showed that administration of anthocyanins lessened the effects of adenine-induced CKD. 71 The underlying mechanism of the positive effect of anthocyanins in this rat model was suggested to be by acting as an antagonist to oxidative stress and by decreasing the inflammation response. Anthocyanins could therefore be a potential dietary agent to consider in the treatment of CKD.…”

Section: Targeting Mitochondrial Dysfunction In Ckdmentioning

confidence: 89%

“…Although anthocyanins seem to be electron acceptors in complex I‐mediated oxidation of NADH and provide cardioprotection, the effects of this polyphenol have not been tested in the context of CKD. However, using an adenine‐induced CKD model in rats recently showed that administration of anthocyanins lessened the effects of adenine‐induced CKD . The underlying mechanism of the positive effect of anthocyanins in this rat model was suggested to be by acting as an antagonist to oxidative stress and by decreasing the inflammation response.…”

Section: Nutritional Strategies Targeting Mitochondrial Dysfunction Imentioning

confidence: 97%

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Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Mafra

Gidlund

Borges

et al. 2018

Eur J Clin Investigation

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Chronic kidney disease (CKD), which affects 10%-15% of the population, associates with a range of complications-such as cardiovascular disease, frailty, infections, muscle and bone disorders and premature ageing-that could be related to alterations of mitochondrial number, distribution, structure and function. As mitochondrial biogenesis, bioenergetics and the dynamic mitochondrial networks directly or indirectly regulate numerous intra-and extracellular functions, the mitochondria have emerged as an important target for interventions aiming at preventing or improving the treatment of complications in CKD. In this review, we discuss the possible role of bioactive food compounds and exercise in the modulation of the disturbed mitochondrial function in a uraemic milieu.

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Section: Targeting Mitochondrial Dysfunction In Ckdmentioning

confidence: 89%

Section: Nutritional Strategies Targeting Mitochondrial Dysfunction Imentioning

confidence: 97%

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Mafra

Gidlund

Borges

et al. 2018

Eur J Clin Investigation

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“…Notably, delphinidin also prevents muscle atrophy in mice (266) and lowers fasting glycaemia in prediabetic individuals (267). Moreover, dietary supplementation with anthocyanins isolated from roselle (Hibiscus sabdarrifa) attenuated progression of adenineinduced CKD in rats (268). Since a causal role for senescent cells in ageing-related bone loss has been demonstrated in mice (269) nutritional compounds with senolytic effects , such as quercetin and fisetin (270) -found in fruits, capers, vegetables and berries -may also contribute to the capacity of bears to maintain their bone mass (242).…”

Section: Major Differences Exist In Levels Of Serum Biomarkers Of Micmentioning

confidence: 99%

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Stenvinkel

Painer²,

Kuro‐o

et al. 2018

Nat Rev Nephrol

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Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress. Biomimetic studies suggest that the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) offers protection in extreme environmental conditions and promotes longevity in the animal kingdom. Similarly, during months of fasting, immobilization and anuria, hibernating bears are protected from muscle wasting, azotaemia, thrombotic complications, organ damage and osteoporosis - features that are often associated with CKD. Improved understanding of the susceptibility and protective mechanisms of these animals and others could provide insights into novel strategies to prevent and treat several human diseases, such as CKD and ageing-associated complications. An integrated collaboration between nephrologists and experts from other fields, such as veterinarians, zoologists, biologists, anthropologists and ecologists, could introduce a novel approach for improving human health and help nephrologists to find novel treatment strategies for CKD.

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“…The pathophysiological basis of CKD and its complications include inflammation, oxidative stress and apoptosis, features that are always seen in human beings and animals with CKD [14-16]. There are also major mediators of the disease such as C-reactive protein, tumor necrosis factor and other cytokines, and several markers of nitrosative and oxidative stress, exerting similar effects in CKD models in rats [16-19].…”

Section: Introductionmentioning

confidence: 99%

Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease

Za’abi

Al-Salam

Suleimani

et al. 2018

Cell Physiol Biochem

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Background/Aims: The effect of treatment with gum acacia (GA), a prebiotic shown previously to ameliorate chronic kidney disease (CKD), in diabetic and non – diabetic rats with adenine – induced CKD has been investigated using several conventional and novel physiological, biochemical, and histopathological parameters. Methods: Diabetes mellitus was induced in rats by a single injection of streptozotocin (STZ). Diabetic and non – diabetic rats were randomly divided into several groups, and given either normal food or food mixed with adenine (0.25% w/w, for five weeks) to induce CKD. Some of these groups were also concomitantly treated orally with GA in the drinking water (15% w/w). Results: Rats fed adenine alone exhibited physiological (decreased body weight, increased food and water intake and urine output), biochemical (increase in urinary albumin/creatinine ratio, plasma urea and, creatinine, indoxyl sulfate and phosphorus), inflammatory biomarkers (increased in neutrophil gelatinase-associated lipocalin, transforming growth factor beta -1, tumor necrosis factor alpha, adiponectin, cystatin C and interleukin-1β), oxidative biomarkers (8-isoprostane, 8 -hydroxy -2-deoxy guanosine), nitrosative stress biomarkers (nitrite and nitrate) and histopathological (increase in tubular necrosis and fibrosis) signs of CKD. STZ - induced diabetes alone worsened most of the renal function tests measured. Administration of adenine in STZ – diabetic rats further worsened the renal damage induced by adenine alone. GA significantly ameliorated the renal actions of adenine and STZ, given either singly or in combination, especially with regards to the histopathological damage. Conclusion: GA is a useful dietary agent in attenuating the progression of CKD in rats with streptozotocin-induced diabetes.

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Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease

Cited by 42 publications

References 46 publications

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Gum Acacia Improves Renal Function and Ameliorates Systemic Inflammation, Oxidative and Nitrosative Stress in Streptozotocin-Induced Diabetes in Rats with Adenine-Induced Chronic Kidney Disease

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