Effect of Aqueous Extract from Phaseolus vulgaris Pods on Lipid Peroxidation and Antioxidant Enzymes Activity in The Liver and Kidney of Diabetic Rats

Abstract

The social significance of diabetes mellitus lies in the fact that in addition to significant prevalence, this disease is associated with many complications. To facilitate the course of diabetes and its complications medicinal plants are widely used in traditional medicine. One of such plants is kidney bean (Phaseolus vulgaris). This plant is used in traditional medicine, especially for the secondary complications of diabetes. Since complications of diabetes are often associated with increased oxidative stress, the study of antioxidant properties of P. vulgaris is important to clarify the mechanism of its therapeutic effect. Present investigation shows that long-term oral administration of aqueous P. vulgaris pods extract in dose of 200mg/kg b.w. besides its pronounced hypoglycemic action also has a positive influence on the liver and kidney function markers in STZ-treated diabetic rats. The extract also inhibits free radical production and lipid peroxidation and activates antioxidant enzymes in liver and kidneys of rats with STZ-induced diabetes. Thus, our data reveal antioxidant properties of aqueous P. vulgaris pods extract that might have beneficial effect in treatment of diabetes.

Dose dependent hepatotoxic effects of dry seed phaseolus vulgaris linn. (red kidney beans) on rabbits

“…These tests involve the screening of blood, which gives information about a wide range of disease conditions (HALL & CASH, 2012). It is well understood that any destruction or damage to liver causes the release of enzymes from hepatocytes into the serum and later on the condition advances to necrosis or leads to alteration in cell membrane permeability (KYZNIETSOVA et al, 2015). ALT is predominantly present in hepatocellular cytoplasm, on the other hand, 80% of AST exists in the mitochondria of cells.…”

Substitusi Tepung Ampas Kedelai pada Mie Basah sebagai Inovasi Makanan Penderita Diabetes

“…β-karoten merupakan salah satu jenis antioksidan yang memberikan manfaat pada penderita diabetes melitus. Penderita DM mengalami kondisi stres oksidatif yang dapat menyebabkan terjadinya komplikasi DM mikrovaskular maupun makrovaskular [26]. Pemberian antioksidan memberikan efek positif terhadap kondisi stres oksidatif, sehingga dapat membantu mempercepat pengobatan DM dan mencegah terjadinya komplikasi [27,28].…”

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“…Antioxidants Estimation: Antioxidants like CAT assayed by the method of Sinha (1972) 19 while SOD used by the method of Kakkar et al, 1984 20 and MDA determined by the method of Satoh K, 1978 21 in blood serum and brain homogenate. The absorbance of catalase was measured at 530 nm.…”