Effect of aqueous extract of Hibiscus sabdariffa on some biochemical parameters in alloxan-induced diabetic rats

Emeka, Patrick; Nwaigwe, Chioma Uchenna; Okwuagwu, Flora Ogbonne; Udem, Samuel Chukwuneke; Asuzu, Isaac Uzoma

doi:10.1007/s00580-014-1889-7

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Pretreatment with Hibiscus sabdariffa extract was observed to significantly increase the PCV, RBC, Hb values in dose dependent manner with beneficial decrease in WBC. Our results corroborated earlier reports that the extract increased PCV, RBC and Hb concentration (Olusola et al, 2012;Agbai and Nwanegwo, 2013;Emelike and Dapper, 2013). Studies have highlighted the role of polyphenolic acid, flavonoids and anthocyanins that may act as antioxidants contributing to Hibiscus sabdariffa medicinal merits (Da-Costa-Rocha et al, 2014).…”

Section: Discussionsupporting

confidence: 92%

“…The observed effects of the extract in this study might be due to the high ascorbic acid component (Falade et al, 2005) or other antioxidants present in the extract, which possibly reduced the free radicals and enhanced erythropoiesis for blood cell formation. For example, anthocyanins, a group of flavonoid derivatives and natural pigments present in the dried flowers of Hibiscus sabdariffa (Da-Costa-Rocha et al, 2014), which reduces loss of blood cells to lipid peroxidation (Degenhardt et al, 2000;Ologundudu et al, 2009) has been implicated to induce renal secretion of erythropoietin, a biological signal for differentiation and multiplication of the pluripotent stem cells involved in blood formation (Kaur and Kapoor, 2005;Agbai and Nwanegwo, 2013). Increase in hemoglobin concentration further support the use of this medicinal plant in folk medicine against anemia.…”

Section: Discussionmentioning

confidence: 98%

“…Similar result was obtained in a study by Olatunji et al (2005a) that reported non-significant effect of red and green petal extracts of Hibiscus sabdariffa on hematological parameters. Agbai and Nwanegwo (2013) conducted an acute toxicity test study on methanolic calyx extract of Hibiscus sabdariffa and found that LD 50 was above 5000 mg kgG 1 . These findings are consistent with the dose administered in MEHS control group in this study that demonstrated no toxicity in the blood.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Pretreatment of Rats with Calyx Extract of Hibiscus sabdariffa against Carbon Tetrachloride-induced Hematotoxicity

Famurewa¹,

Kanu²,

Ogugua³

et al. 2015

J. of Biological Sciences

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Beneficial health impact of medicinal plants reported in scientific literature includes enhancement of antioxidant defense mechanism and amelioration of toxicities. The present study aimed to investigate the pre and post-treatment protective effects of methanolic extract of Hibiscus sabdariffa (MEHS) on CCl 4-induced hematotoxicity and alterations in lipid profile in rats. The 55 rats were randomly divided into 11 groups of 5 animals each. The pretreatment and post treatment groups were administered 200, 600 and 1000 mg kgG 1 doses of MEHS 10 days before and after oral administration of CCl 4 (2.5 mL kgG 1 b.wt.), respectively. Hematological parameters and serum lipids were analyzed by standard methods. The administration of CCl 4 significantly induced hematotoxicity as evidenced by decreased RBC, PCV and Hb with significantly increased WBC count (p<0.05). The pretreatment with MEHS and vitamin E significantly (p<0.05) increased the RBC, PVC and Hb concentration. Similarly, MEHS doses at 600 and 1000 mg kgG 1 and vitamin E 9.6 mg kgG 1 b.wt., significantly decreased WBC (p<0.05). In the post-treatment, there were beneficial significant changes in all treatments for PCV, at 1000 mg kgG 1 MEHS for Hb and at vitamin E administration for Hb and WBC count. However, there were no significant differences observed in both treatment approaches for serum lipid concentrations compared to CCl 4-treated rats (p>0.05). The data from this study suggest the prophylactic protective role of MEHS against hematotoxicity in carbon tetrachloride challenge.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Protective Effect of Pretreatment of Rats with Calyx Extract of Hibiscus sabdariffa against Carbon Tetrachloride-induced Hematotoxicity

Famurewa¹,

Kanu²,

Ogugua³

et al. 2015

J. of Biological Sciences

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“…Hibiscus was equally effective as gilbenclamide (a drug therapy for type 2 diabetes) in reducing blood glucose levels in rats with induced diabetes. 87 In addition, hibiscus mitigated increases in cholesterol and LDL levels in alloxan-induced diabetes in mice by 29% and 40%, respectively, which was comparable to the effects of the cholesterol-lowering drug lovastatin. 88 The effect of hibiscus on HDL was similar to that of pravastatin in the only human study to have examined effects in adults with hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 80%

A systematic review and meta-analysis of the effects of Hibiscus sabdariffa on blood pressure and cardiometabolic markers

et al. 2022

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Context Hibiscus sabdariffa (hibiscus) has been proposed to affect cardiovascular risk factors. Objective To review the evidence for the effectiveness of hibiscus in modulating cardiovascular disease risk markers, compared with pharmacologic, nutritional, or placebo treatments. Data Sources A systematic search of the Web of Science, Cochrane, Ovid (MEDLINE, Embase, AMED), and Scopus databases identified reports published up to June 2021 on randomized controlled trials using hibiscus as an intervention for lipid profiles, blood pressure (BP), and fasting plasma glucose levels in adult populations. Data Extraction Seventeen chronic trials were included. Quantitative data were examined using a random effects meta-analysis and meta-regression with trial sequential analysis to account for type I and type II errors. Data Analysis Hibiscus exerted stronger effects on systolic BP (−7.10 mmHg [95%CI, −13.00, −1.20]; I2 = 95%; P = 0.02) than placebo, with the magnitude of reduction greatest in those with elevated BP at baseline. Hibiscus induced reductions to BP similar to that resulting from medication (systolic BP reduction, 2.13 mmHg [95%CI, −2.81, 7.06], I2 = 91%, P = 0.40; diastolic BP reduction, 1.10 mmHg [95%CI, −1.55, 3.74], I2 = 91%, P = 0.42). Hibiscus also significantly lowered levels of low-density lipoprotein compared with other teas and placebo (−6.76 mg/dL [95%CI, −13.45, −0.07]; I2 = 64%; P = 0.05). Conclusions Regular consumption of hibiscus could confer reduced cardiovascular disease risk. More studies are warranted to establish an effective dose response and treatment duration. Systematic Review Registration PROSPERO registration no. CRD42020167295

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“…The hypoglycemic effect of aqueous extracts from roselle calyces was also confirmed in a study performed on rats with diabetes that was induced by a single administration of alloxan at a dose of 150 mg/kg b.w. [ 103 ]. These diabetic rats were orally administered with roselle calyx extract at a dose of 30 mg/mL ad libitum for 21 days, and it turned out that the treatment resulted in significantly lower blood glucose levels in comparison to the untreated rats [ 103 ].…”

Section: Hibiscus Sabdariffa In Diabetic and Pre-diabetic An...mentioning

confidence: 99%

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

Jamrozik

Borymska

Kaczmarczyk-Sedlak

2022

Foods

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Diabetes is currently a global health problem that is already reported as an epidemic. This metabolic disease, characterized by a disturbance in the carbohydrate, protein, and lipid metabolism, is often accompanied by disorders of several organs. Its treatment is expensive and often difficult to control. Therefore, it seems necessary to search for new drugs and solutions to facilitate therapy and reduce treatment costs. Herbal medicines are becoming more and more popular. Hibiscus sabdariffa (roselle) is a plant that grows wild in a tropical climate. It has been used in folk medicine for thousands of years. Thanks to the numerous active compounds, including polyphenols, polysaccharides, organic acids, or pectins, it is reported to exhibit hypoglycemic, antioxidant, hypotensive, and anti-lipidemic activities and numerous indirect effects that are related to them. The aim of this review was to update the knowledge about the therapeutic effects of roselle in diabetes and its comorbidities based on in vitro, animal, and human studies. After a careful analysis of the scientific literature, it can be stated that roselle is a promising product that can be used either on its own or as an addition to the conventional treatment regimens to prevent or treat diabetes and its accompanying diseases.

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Effect of aqueous extract of Hibiscus sabdariffa on some biochemical parameters in alloxan-induced diabetic rats

Cited by 8 publications

References 17 publications

Protective Effect of Pretreatment of Rats with Calyx Extract of Hibiscus sabdariffa against Carbon Tetrachloride-induced Hematotoxicity

Protective Effect of Pretreatment of Rats with Calyx Extract of Hibiscus sabdariffa against Carbon Tetrachloride-induced Hematotoxicity

A systematic review and meta-analysis of the effects of Hibiscus sabdariffa on blood pressure and cardiometabolic markers

Hibiscus sabdariffa in Diabetes Prevention and Treatment—Does It Work? An Evidence-Based Review

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