Effect of aqueous ginger (Zingiber officinale) extract on sperm quality and haematology in lead acetate-treated male albino rats

Odo, Rita Ifeoma; Mbegbu, Edmund Chidiebere; Anyanwu, Lawrence N.

doi:10.4314/tjpr.v19i7.21

Cited by 5 publications

(8 citation statements)

References 12 publications

(15 reference statements)

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“…These data suggested that ginger may help maintain healthy sperm parameters (Al-Kashef 2021). Recently, ginger extract had potential to improve semen quality and quantity in lead acetate-treated male rats (Banihani 2018; Odo et al 2020). Moreover, Morakinyo et al (2008) found that GE was significantly increase the relative weight of the rat testis as well as serum testosterone levels.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Banihani (2018) attributed the possible mechanisms of improved male fertility by ginger extract due to its ability to increase testosterone production, reduce oxidative stress, enhance the activity of antioxidant enzymes, and normalize blood glucose levels. Ginger extract has potential to improve semen quality and quantity in lead acetate-treated male rats (Odo et al 2020). The purpose of this study was to see how coadministration of GE and Vit.…”

Section: Introductionmentioning

confidence: 99%

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Coadministration of Ginger Roots Extract and Vitamin E Improves Male Fertility of Streptozotocin-Induced Diabetic Rats

2022

Int J Vet Sci

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Ginger is an important medicinal plant in folk medicine. Antioxidant, antidiabetic, and anti-inflammatory effects have been reported in ginger extracts. This study was performed to examine how ginger extract (GE) and vitamin E (Vit E) have affected the fertility in Streptozotocin-induced diabetic male rats. Sixty adult male rats were randomly assigned into six groups (n=10). Group 1 served as a negative control, while the other animals were intraperitoneally injected with Streptozotocin (50mg/kg) after fasting for 16 hours to induce diabetes. Group 2 was kept as a diabetic positive control. While groups 3 and 4 were orally given GE alone at 300 and 600mg/kg for 65 consecutive days to cover the whole spermatogenic cycle in rats, respectively. For the same period, groups 5 and 6 received GE (300 and 600mg/kg) plus Vit E (200mg/kg). Serum samples were obtained to estimate blood glucose, insulin, testosterone, FSH, and LH levels. Sex organs have been weighed, besides semen picture and histopathology of the testis were carried out. The results revealed that co-administration of GE and Vit. E increased the fertility index, weights of the testis and epididymis, serum testosterone level and improved semen quality in Streptozotocin-induced diabetic rats. Moreover, co-administration of GE and Vit. E caused hypoglycemia and hypoinsulinemia in administered rats compared to the diabetic positive control. Mild to moderate testicular degeneration and incomplete arrest of spermatogenesis were seen by histopathological examination of diabetic control group. Moreover, GE and Vit. E alleviated testicular lesions induced by diabetes, and improved spermatogenesis in treated groups. Conclusively, diabetic patients who are sexually impotent may benefit from a dietary supplement containing ginger roots and vitamin E.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Coadministration of Ginger Roots Extract and Vitamin E Improves Male Fertility of Streptozotocin-Induced Diabetic Rats

2022

Int J Vet Sci

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“…Also, the treatment increased the viability of TM3 and TM4 cells (Rafiee et al, 2019). Odo et al (2020) evaluated the preventive effect of ginger extract against lead acetate on sperm quality and haematology in male rats. In this study, the simultaneous ingestion of lead acetate with aqueous ginger extract (300 mg/kg) for 6 weeks induced a significant increase in the spermatozoa parameters (viability and motility), and the production of red blood cells.…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

“…Also, the level of white blood cells was significantly reduced. The ameliorative impact of ginger on spermatozoa parameters may be associated with its antioxidant properties, and the presence of vitamin C (Odo et al, 2020).…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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“…Many studies revealed that ginger has various activities such as immune-modulatory, antioxidant and anti-apoptosis (Hosseinzadeh et al, 2017). Zingiber has a constructive influence on improved sperm numbers, motility, testosterone levels, and reproductive activities in rats (Odo et al, 2020;Seif et al, 2021). Consequently, this study has been conducted out to assess the defending effects of the ethanolic extract of ginger against the testicular alterations produced by MSG administration on male albino rats.…”

Section: Introductionmentioning

confidence: 99%

Possible Ameliorative Role of Ethanolic Ginger Extract (Zingiber officinale) against Testicular Toxicity Induced By Monosodium Glutamate In Albino Rats

Mohamed

Kamel

2021

Egyptian Academic Journal of Biological Sciences, B. Zoology

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The paper aims to investigate the protective effect of ethanolic ginger extract against Monosodium glutamate (MSG) induced reproductive disorders in male rats. Forty-eight male albino rats were separated into four experimental groups: normal control, ginger extract, MSG only, and MSG plus ginger extract groups. All experimental regimens were administrated orally for four weeks. Dissection was done after two and four weeks from the starting of the experiment. Body and testis weight, sperm abnormalities, biochemical investigations were recorded.Additionally, molecular, histopathological, and immunohistochemical techniques in testis tissue were performed. The present data shows a significant increase in body weight, sperm abnormalities, and serum total cholesterol, with a significant decline in testis weight, serum Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), and testosterone levels after MSG administration. There was an upregulation in the expression of Bax protein whereas downregulation in the expression of B-cell lymphoma-2 (BCL-2) protein in the MSG group when compared with the normal control. Furthermore, testicular alterations were distinguished in the group treated with MSG only, along with enhanced caspase-3 and declined BCl-2 positive cells in testis tissue. While administration with ethanolic ginger extract showed an ameliorative effect contrasted with testicular alterations produced by Monosodium glutamate. Study Protocol:Rats were left for one week as an acclimatization period before treatment. The animals were separated into 4 experimental groups (12 animal/group). The first group served as the normal control group which was given distilled water. The second group was given Ginger Extract (GE ) only at 50 mg/kg b.wt according to (Bordbar et al., 2013), while the third group received MSG only at 2 mg/g b.wt according to (Igwebuike et al., 2011). Finally, the 4 th group was received GE at 50 mg/kg b.wt, and MSG at 2 mg/g b.wt. All experimental regimens were given orally to rats for 4 consecutive weeks daily, animals were dissected after two and four weeks from the beginning of the experiment. Samples Collection:After two and four weeks, the weight of each animal was documented, then all rats were autopsied through diethyl ether (Sigma, USA) inhalation anesthesia, after which animals were carefully dissected. Epididymis was removed for sperm abnormalities and testes weights were recorded. Blood was collected by cardiac acupuncture in centrifuge tubes left to clot and centrifuged at 3000 rpm for twenty minutes. then serum was collected and kept at −20°C till usage. All animals tests were collected for molecular and histochemical studies. Sperm Head Abnormality Test:Sperm-shape abnormalities were made according to the method described by Wyrobek ( 1978). In detail, caudal epididymis was sited in a Petri-dish containing one ml of NaCl (0.9 %). The epididymis was cut off into small pieces to allow the sperms to get out. Then, three drops of this solution were used to prepare the smears. The sl...

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Effect of aqueous ginger (Zingiber officinale) extract on sperm quality and haematology in lead acetate-treated male albino rats

Cited by 5 publications

References 12 publications

Coadministration of Ginger Roots Extract and Vitamin E Improves Male Fertility of Streptozotocin-Induced Diabetic Rats

Coadministration of Ginger Roots Extract and Vitamin E Improves Male Fertility of Streptozotocin-Induced Diabetic Rats

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Possible Ameliorative Role of Ethanolic Ginger Extract (Zingiber officinale) against Testicular Toxicity Induced By Monosodium Glutamate In Albino Rats

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