Effect of Aqueous Stem Bark Extract of<i>Khaya senegalensis</i>on Some Biochemical, Haematological, and Histopathological Parameters of Rats

Onu, Andrew; Saidu, Yauba; Ladan, MJ; Bilbis, L. S.; Aliero, Adamu Almustapha; Sahabi, Saddiku Malami

doi:10.1155/2013/803835

Cited by 22 publications

(27 citation statements)

References 23 publications

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“…Because the rats from the CF + GL and the CF + AP groups consumed GL and AP mushrooms with the CF, the cytotoxic and oxidative stress caused by CF were ameliorated and the body weight gain was restored (by 18.65% and 8.79%, respectively) compared with the negative control group. Our study also confirmed that oral administration of CF at 1 mg/kg body weight for consecutive 28 days has significant ( p < 0.05) adverse effect on the mean relative liver weights, because the liver is the first organ exposed to metabolizing any upcoming metabolites from gastrointestinal tract following oral ingestion [ 27 ]. However, the CF administration had no significant ( p < 0.05) effects on the other organs, such as kidney, heart, brain, and pancreas perhaps because of the low bioavailability; that is, the low dose of CF was less likely to cause large scale toxicity through the body [ 28 ].…”

Section: Discussionsupporting

confidence: 77%

Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran‐Induced Toxicity in Rats

Hossen

Prince

Tanvir

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The current study aimed to investigate the ameliorative effects of two types of mushrooms, Ganoderma lucidum (GL) and Auricularia polytricha (AP), against carbofuran- (CF) induced toxicity in rats. Male Wistar rats (n = 42) were divided into six equal groups. The rats in the negative control group received oral administration of CF at 1 mg/kg with the normal diet for 28 days. The treatment groups received oral administration of ethanolic extract of GL or AP at 100 mg/kg followed by coadministration of CF at 1 mg/kg with the normal diet for the same experimental period, respectively. In the CF alone treated group, there were significant decreases in the erythrocytic and thrombocytic indices but increases in the concentrations of the total leukocytes, including the agranulocytes. A significant increase in all of the liver function biomarkers except albumin, in lipid profiles except high-density lipoprotein, and in the kidney function markers occurred in the negative control group compared to the rats of the normal control and positive control groups. The coadministration of mushroom extracts significantly ameliorated the toxic effects of the CF. The GL mushroom extract was more efficacious than that of the AP mushroom, possibly due to the presence of high levels of phenolic compounds and other antioxidants in the GL mushroom.

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Section: Discussionsupporting

confidence: 77%

Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran‐Induced Toxicity in Rats

Hossen

Prince

Tanvir

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Although both pulp and peel extracts were investigated in this study, the peel extract exhibited a higher level of antioxidant activity than the pulp, which supports the findings of previous studies (Abu-Amsha et al, 1996) As an organ of detoxification, the liver is the first organ that encounters all materials that are absorbed from the gastrointestinal tract. It has been shown to react to toxicological insults in a number of ways, including undergoing cellular degeneration, necrosis, bile duct hyperplasia and fibrosis (Onu et al, 2013). In this study, liver function was evaluated by determining the activities of various serum enzymes (ALT, AST, ALP, GGT and LDH), metabolites (TB) and plasma proteins (TP and ALB).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Properties of Citrus macroptera Fruit and Its in vivo Effects on the Liver, Kidney and Pancreas in Wistar Rats

Khalil¹,

Paul²,

Hossen³

et al. 2015

International J. of Pharmacology

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In this study, the antioxidant potential of Citrus macroptera fruit was compared between its pulp (CMPU) and peel (CMPE). The biochemical effects of an ethanol extract of CMPU were investigated on major organs, including the liver, kidney and pancreas. Male wistar rats (n = 24) were randomly divided into four groups, including Group I (control), Group II (250 mg kgG 1), Group III (500 mg kgG 1) and Group IV (1000 mg kgG 1) and they were administered the extract for 28 days. The CMPE contained higher amounts of total polyphenols (620.91±7.75 mg), flavonoids (508.33±5.49 mg), tannins (585.99±4.46 mg) and protein (4.00±0.14 g) compared to the pulp (291.06±10.14, 145.02±0.36, 526.08±3.32 mg/100 g and 2.89±0.32 g/100 g, respectively). Similarly, CMPE also exhibited higher 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging activity and Ferric Reducing Antioxidant Power (FRAP) values than CMPU. However, the ascorbic acid content was higher in CMPU (120.83±0.0019 mg/100 g) than CMPE. In vivo studies confirmed that CMPU possessed a significant lipid lowering activity that occurred in a dose dependent manner and that it caused beneficial changes in several other biochemical parameters. Additionally, a significant diminution of lipid peroxidation in liver and kidney tissues was observed. It was concluded that C. macroptera possesses high antioxidant potential and is relatively safe. Its protective effects against various chronic diseases that are associated with oxidative stress should be further investigated.

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“…Malaria [159,166], scabies, control blood sugar levels [167], tuberculosis [30] Antibacterial activity against S. typhi and antifungal activity against C. albicans (n-hexane extract) [168], antioxidant and antibacterial properties (50% ethanol leaf extract) [169] in vitro (Ditch well diffusion method) [168], in vitro (Agar well diffusion method [169] The aqueous and methanol leaf extracts were reported to be non-toxic against MRC-5 cells (CC 50 > 32 µg/mL) [96] The methanol leaf extract was reported to be toxic to brine shrimp larvae (LC 50 = 233.061 µg/mL) [42] The aqueous and methanol leaf extracts were reported to be toxic to brine shrimp larvae (LC Orally administered ethanol stem bark extract in rats at a dose of 2 mg/kg for 18 days was reported to induce the synthesis of liver enzymes [175]. The subchronic administration of the aqueous stem bark extract to rats was reported to affect the cellular integrity of vital organs of the body [176]. Sub-chronic administration of the aqueous stem bark extract in albino rats was reported to cause the elevation of liver enzymes, and to Increase plasma total protein, blood urea, and creatinine [177].…”

Section: No Reportsmentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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Effect of Aqueous Stem Bark Extract ofKhaya senegalensison Some Biochemical, Haematological, and Histopathological Parameters of Rats

Cited by 22 publications

References 23 publications

Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran‐Induced Toxicity in Rats

Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran‐Induced Toxicity in Rats

Antioxidant Properties of Citrus macroptera Fruit and Its in vivo Effects on the Liver, Kidney and Pancreas in Wistar Rats

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

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