Effect of arginine on angiogenesis induced by human colon cancer: in vitro and in vivo studies

Alterative Expression of Angiogenic Proteins by Arginine in SW620 Cell-Inoculated Nude Mice

“…However, the results of this study contradict a previous report performed by our laboratory, which showed that Arg supplementation increased NO secretion and may consequently inhibit the progression of colon cancer. 10 In that experiment, colon primary adenocarcinoma cells (SW480) were used, whereas metastatic colon carcinoma SW620 cells were selected in this study. Zhou et al 28 revealed that SW620 cells had higher tissue factor expression than did SW480 cells.…”

“…This amount of Arg was previously found to enhance the immune response 14,15 and have effects on inhibiting the progression of primary colon cancer in rodents. 10 Although casein was isonitrogenously substituted by Arg, the amount of protein in the Arg group was adequate for growth and maintenance according to the reported nutrient requirements for mice. 16 The diets were sterilized and stored at À20 C in bags.…”

“…Our laboratory demonstrated that Arg supplementation inhibits the progression of primary colon cancer (SW480) in in vivo and in vitro models. 10 However, a report by Park et al 11 described an increase in tumor proliferation markers in patients with breast cancer treated with dietary Arg supplements. Yerushalmi et al 12 also found that Arg promotes colonic tumorigenesis in intestinal neoplastic mice.…”

Effects of Arginine Supplementation on Exogenous Advanced Glycation End Product-induced Renal Inflammatory Mediator Expression in Rats

“…This amount of Arg was used because it has been proven to have regulatory effects on immune responses. 17 The tail vein injection and the diets for the respective group were given daily for a duration of 10 days. After 10 days, all rats were anesthetized and sacrificed by drawing arterial blood from the aorta of the abdomen.…”

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells

“…Yeh et al [157] showed that arginine at 1,000 μmol/L can lower the production of VEGF, bFGF, and MMP-2 in SW480 human colon cancer cells. Moreover, they showed that supplementation of arginine in the diet of SW480 colon cancer cells xenograft mouse model resulted in lower MMP-2, MMP-9, and VEGF receptor levels in tumors and higher NO and spleen NK compared to a control group.…”