Effect of arginine vasopressin on breathing movements of chronically instrumented fetal lambs

Bessho, Takefumi; Murata, Yuji; Ninomiya, Yuko; Ibara, Satoshi; Yamamoto, Tatsuo; Miyake, Yoichi; Tyner, James G.

doi:10.3109/00016349709050063

Cited by 4 publications

(5 citation statements)

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“…The values of hematocrit for sheep of all ages, market‐age sheep, lambs, and fetal sheep are reported in Tables 17 , 18 , 19 , and 20 , respectively. The hematocrit for sheep of all different ages was calculated based on 24 studies (Alhidary et al., 2012 ; Anosa & Isoun, 1976 ; Bessho et al., 1997 ; Campbell et al., 2014 ; Carver & Hay, 1995 ; Ceï et al., 2018 ; Degen & Young, 1981 ; Gomes et al., 2013 ; Hart & Doyle, 1985 ; Horton & Burgher, 1992 ; Jobe et al., 1998 ; Maraba et al., 2018 ; Marsh et al., 2001 ; Matson et al., 1981 ; Mayland et al., 1986 ; Meyer‐Gesch et al., 2013 ; Rege et al., 2002 ; Robillard & Weitzman, 1980 ; Roghair et al., 2004 ; Saylor & Leach, 1980 ; Singh et al., 2018 ; Talke et al., 1985 ; Tran et al., 2000 ; Vannucchi et al., 2012 ), and the average value was 36.15% (Table 17 ). The value of hematocrit for goats was calculated based on five different studies (Anosa & Isoun, 1976 ; Courtice, 1943 ; McKean & Walker, 1974 ; Olsén et al., 2013 ; Olsson et al., 1994 ), and the average value was 29.38% (Table 21 ).…”

Section: Resultsmentioning

confidence: 99%

“… Note The hematocrit of sheep with all ages was calculated based on 24 studies (Alhidary et al., 2012 ; Anosa & Isoun, 1976 ; Bessho et al., 1997 ; Campbell et al., 2014 ; Carver & Hay, 1995 ; Ceï et al., 2018 ; Degen & Young, 1981 ; Gomes et al., 2013 ; Hart & Doyle, 1985 ; Horton & Burgher, 1992 ; Jobe et al., 1998 ; Maraba et al., 2018 ; Marsh et al., 2001 ; Matson et al., 1981 ; Mayland et al., 1986 ; Meyer‐Gesch et al., 2013 ; Rege et al., 2002 ; Robillard & Weitzman, 1980 ; Roghair et al., 2004 ; Saylor & Leach, 1980 ; Singh et al., 2018 ; Talke et al., 1985 ; Tran et al., 2000 ; Vannucchi et al., 2012 ). …”

Section: Resultsmentioning

confidence: 99%

“… Note The hematocrit of fetal sheep was calculated based on five studies (Bessho et al., 1997 ; Jobe et al., 1998 ; Meyer‐Gesch et al., 2013 ; Robillard & Weitzman, 1980 ; Roghair et al., 2004 ). The value of hematocrit for fetal sheep is 37.29% based on these studies.…”

Section: Resultsmentioning

confidence: 99%

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Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food‐producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in tables. Equations describing the growth curves of sheep and goats are presented in figures. When data are sufficient, parameter values are reported for different ages or production classes of sheep, including fetal sheep, lambs, and market‐age sheep (mature sheep). These data provide a reference database for developing standardized PBPK models to predict drug withdrawal intervals in sheep and goats, and also provide a basis for extrapolating PBPK models from major species such as cattle to minor species such as sheep and goats.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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“…General surgical procedures are described in detail elsewhere (9). Briefly, four pregnant cross-bred ewes were anesthetized by intramuscular Rom-puni@ with additional use of Lidocaine.…”

Section: Methodsmentioning

confidence: 99%

Effect of respiratory acidosis on body movements in the chronically instrumented fetal lamb

Bessho

Taira

Koyama

1997

Acta Obstet Gynecol Scand

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“…Intravenous infusions of AVP transiently decrease pulmonary ventilation and phrenic nerve activity in conscious dogs ( Ohtake and Jennings, 1993 ), anesthetized and awake rats ( Louwerse and Marshall, 1993 ; Walker and Jennings, 1998 ; Żera et al, 2018 ; Brackley and Toney, 2021 ) and fetal lambs ( Bessho et al, 1997 ). Recently published pilot study in patients with autosomal dominant polycystic kidney disease showed that upon initiation of treatment with tolvaptan, a selective V2R antagonist, plasma copeptin level increased 6-fold and this was associated with a modest but significant increase in arterial carbon-dioxide and plasma acidity ( Heida et al, 2021 ), suggestive of ventilatory inhibition by increased AVP levels in the bloodstream and enhanced stimulation of V1 receptors, which were not blocked by tolvaptan.…”

Section: The Respiratory Effects Of Vasopressinmentioning

confidence: 99%

Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone

et al. 2021

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Vasopressin (AVP) is a key neurohormone involved in the regulation of body functions. Due to its urine-concentrating effect in the kidneys, it is often referred to as antidiuretic hormone. Besides its antidiuretic renal effects, AVP is a potent neurohormone involved in the regulation of arterial blood pressure, sympathetic activity, baroreflex sensitivity, glucose homeostasis, release of glucocorticoids and catecholamines, stress response, anxiety, memory, and behavior. Vasopressin is synthesized in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus and released into the circulation from the posterior lobe of the pituitary gland together with a C-terminal fragment of pro-vasopressin, known as copeptin. Additionally, vasopressinergic neurons project from the hypothalamus to the brainstem nuclei. Increased release of AVP into the circulation and elevated levels of its surrogate marker copeptin are found in pulmonary diseases, arterial hypertension, heart failure, obstructive sleep apnoea, severe infections, COVID-19 due to SARS-CoV-2 infection, and brain injuries. All these conditions are usually accompanied by respiratory disturbances. The main stimuli that trigger AVP release include hyperosmolality, hypovolemia, hypotension, hypoxia, hypoglycemia, strenuous exercise, and angiotensin II (Ang II) and the same stimuli are known to affect pulmonary ventilation. In this light, we hypothesize that increased AVP release and changes in ventilation are not coincidental, but that the neurohormone contributes to the regulation of the respiratory system by fine-tuning of breathing in order to restore homeostasis. We discuss evidence in support of this presumption. Specifically, vasopressinergic neurons innervate the brainstem nuclei involved in the control of respiration. Moreover, vasopressin V1a receptors (V1aRs) are expressed on neurons in the respiratory centers of the brainstem, in the circumventricular organs (CVOs) that lack a blood-brain barrier, and on the chemosensitive type I cells in the carotid bodies. Finally, peripheral and central administrations of AVP or antagonists of V1aRs increase/decrease phrenic nerve activity and pulmonary ventilation in a site-specific manner. Altogether, the findings discussed in this review strongly argue for the hypothesis that vasopressin affects ventilation both as a blood-borne neurohormone and as a neurotransmitter within the central nervous system.

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Effect of arginine vasopressin on breathing movements of chronically instrumented fetal lambs

Abstract: AVP has an inhibitory effect on FBM. The mechanism of this inhibition was not a direct suppression of the CNS as there was a dissociation between FBM and the electrocortical activity during infusion of AVP.

Cited by 4 publications

References 27 publications

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Effect of respiratory acidosis on body movements in the chronically instrumented fetal lamb

Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone

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