Effect of Aripiprazole on 5-HT2 Receptor–mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats

Kohnomi, Shuntaro; Suemaru, Katsuya; Kawasaki, Hiromu; Araki, Hiroaki

doi:10.1254/jphs.fp0071924

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…Based on these concepts, administration of 5-HT 2A receptor agonists such as 2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) has been used to produce head shakes in mice (Corne et al, 1963; Bedard and Pycock, 1977; Dursun and Handley, 1996) and rats (Pranzatelli, 1988; Berendsen and Broekkamp, 1990; Fone et al, 1991), as well as PPI deficits in rats (Sipes and Geyer, 1994; Kehne et al, 1996). Some of these effects can be countered by both antipsychotic administration (Kohnomi et al, 2008) and mGlu2/3 receptor stimulation (Wischhof et al, 2012). …”

Section: Pharmacological Models Of Tic Disordersmentioning

confidence: 99%

Animal models of tic disorders: A translational perspective

Godar

Mosher

Giovanni

et al. 2014

Journal of Neuroscience Methods

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Tics are repetitive, sudden movements and/or vocalizations, typically enacted as maladaptive responses to intrusive premonitory urges. The most severe tic disorder, Tourette syndrome (TS), is a childhood-onset condition featuring multiple motor and at least one phonic tic for a duration longer than 1 year. The pharmacological treatment of TS is mainly based on antipsychotic agents; while these drugs are often effective in reducing tic severity and frequency, their therapeutic compliance is limited by serious motor and cognitive side effects. The identification of novel therapeutic targets and development of better treatments for tic disorders is conditional on the development of animal models with high translational validity. In addition, these experimental tools can prove extremely useful to test hypotheses on the etiology and neurobiological bases of TS and related conditions. In recent years, the translational value of these animal models has been enhanced, thanks to a significant re-organization of our conceptual framework of neuropsychiatric disorders, with a greater focus on endophenotypes and quantitative indices, rather than qualitative descriptors. Given the complex and multifactorial nature of TS and other tic disorders, the selection of animal models that can appropriately capture specific symptomatic aspects of these conditions can pose significant theoretical and methodological challenges. In this article, we will review the state of the art on the available animal models of tic disorders, based on genetic mutations, environmental interventions as well as pharmacological manipulations. Furthermore, we will outline emerging lines of translational research showing how some of these experimental preparations have led to significant progress in the identification of novel therapeutic targets for tic disorders.

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Section: Pharmacological Models Of Tic Disordersmentioning

confidence: 99%

Animal models of tic disorders: A translational perspective

Godar

Mosher

Giovanni

et al. 2014

Journal of Neuroscience Methods

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“…2.0. The power spectrum densities, integrated and averaged, could be divided into 4 frequency areas: delta wave (0.5 -4 Hz), theta wave (4 -8 Hz), alpha wave (8 -13 Hz), and beta wave (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Delta activity (%) and beta activity (%) were calculated using following equation: Delta (beta) activity (%) = [delta (beta) wave power density in the drug administration period] / [delta (beta) wave power density in vehicle administration period in each animal] × 100.…”

Section: Sleep-wake State Analysismentioning

confidence: 99%

Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia

2009

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Abstract. We studied the effects of antipsychotics and a hypnotic on sleep disturbance in schizophrenia using an animal model of the disease. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were chronically implanted into the cortex and the dorsal neck muscle of rats. EEG and EMG were recorded with an electroencephalograph for 6 h (10:00 -16:00). SleepSign ver. 2.0 was used for EEG and EMG analysis. Haloperidol and olanzapine had an antagonizing effect on the increases in sleep latency and total awake time and the decrease in total non-rapid eye movement (NREM) sleep time induced by MK-801. Olanzapine also antagonized the decrease in total rapid eye movement (REM) sleep time induced by MK-801. Aripiprazole antagonized only the increase in sleep latency induced by MK-801, whereas, risperidone, quetiapine, and flunitrazepam had no effect in the changes of sleep-wake pattern induced by MK-801. Olanzapine increased delta activity and decreased beta activity during NREM sleep. In contrast, flunitrazepam had an opposite effect. It was clarified that haloperidol and olanzapine were effective for decrease of sleep time in this animal model of schizophrenia. In addition, aripiprazole showed a sleep-inducing effect in schizophrenia model rat. On the other hand, flunitrazepam showed no beneficial effect on sleep disturbance in schizophrenia model rat.

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“…Beklendiği üzere, dopamin reseptörleri üzerinden ters etki yaratan ajanlar bu modellerdeki belirtilerde düzelme sağlamıştır (Gilbert ve ark. 2013 Serotonin reseptörü (5HT2A) agonisti 2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) uygulamasıyla farelerin kafalarında sallanmalar oluşturulmuş (Dursun ve Handley 1996) ve sıçanlarda bunların antipsikotik uygulamasıyla düzeldiği gösterilmiştir (Kohnomi ve ark. 2008).…”

Section: C) Farmakolojik Modellerunclassified

Neurobiology of Tourette Syndrome

Unal¹,

Akdemir²

2016

Turkish Journal of Psychiatry

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Effect of Aripiprazole on 5-HT2 Receptor–mediated Wet-Dog Shake Responses and Disruption of Prepulse Inhibition in Rats

Cited by 17 publications

References 17 publications

Animal models of tic disorders: A translational perspective

Animal models of tic disorders: A translational perspective

Effects of Some Antipsychotics and a Benzodiazepine Hypnotic on the Sleep-Wake Pattern in an Animal Model of Schizophrenia

Neurobiology of Tourette Syndrome

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