Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat

Yu, Zheng; Tian, Chunxiao; Dong, Lei; Tian, Lei; Glabonjat, Ronald A.; Xiong, Chan

doi:10.1016/j.neuro.2021.04.002

Cited by 13 publications

(10 citation statements)

References 49 publications

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“…Each electrode can be served as both a stimulating electrode and a recording electrode. After recording a 20-min baseline, high-frequency stimulation (HFS, 1 sweep of 100 pulses, 1 s apart) was applied on the electrode located in the SC of the hippocampus to induce the LTP using an external stimulator (STG-1004, Multi-Channel Systems, Germany) [ 40 ]. The field excitatory postsynaptic potentials (fEPSPs) in the hippocampal CA1 region were subsequently recorded for 100 min by LTP-Director 1.3.2 and LTP-Analyzer1.3.2.…”

Section: Methodsmentioning

confidence: 99%

Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression

Cheng

Tian

et al. 2023

Bioactive Materials

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Section: Methodsmentioning

confidence: 99%

Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression

Cheng

Tian

et al. 2023

Bioactive Materials

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“…This also results in changes in synaptic plasticity, a factor commonly described as the ability of neural tissue to form new synaptic connections and enhance existing ones as a part of memory and learning. To investigate on this particular property, long-term potentiation (LTP) is often taken to model synaptic plasticity, and the MEAtechnology is a valuable tool to measure these events, normally with conventional MEAs, but also with especially designed electrode arrays where hippocampal slices can be placed appropriately on the MEA, so that the Schaffer collaterals can easily be addressed (Zheng et al 2021). LTP can be described as an enhancement of synaptic activity following short, high-frequency stimulation through afferent connections (Chen et al 2000).…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Using multielectrode arrays to investigate neurodegenerative effects of the amyloid-beta peptide

et al. 2021

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Background Multielectrode arrays are widely used to analyze the effects of potentially toxic compounds, as well as to evaluate neuroprotective agents upon the activity of neural networks in short- and long-term cultures. Multielectrode arrays provide a way of non-destructive analysis of spontaneous and evoked neuronal activity, allowing to model neurodegenerative diseases in vitro. Here, we provide an overview on how these devices are currently used in research on the amyloid-β peptide and its role in Alzheimer’s disease, the most common neurodegenerative disorder. Main body: Most of the studies analysed here indicate fast responses of neuronal cultures towards aggregated forms of amyloid-β, leading to increases of spike frequency and impairments of long-term potentiation. This in turn suggests that this peptide might play a crucial role in causing the typical neuronal dysfunction observed in patients with Alzheimer’s disease. Conclusions Although the number of studies using multielectrode arrays to examine the effect of the amyloid-β peptide onto neural cultures or whole compartments is currently limited, they still show how this technique can be used to not only investigate the interneuronal communication in neural networks, but also making it possible to examine the effects onto synaptic currents. This makes multielectrode arrays a powerful tool in future research on neurodegenerative diseases.

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“…A similar study was conducted to evaluate the effects of AsHCs exposure on long-term potentiation (LTP) of synapses in the hippocampal CA1 region. It was found that it enhanced the LTP under 3.75-15 µg As L −1 AsHC 360 exposure, while inhibited LTP was observed under 45-150 µg As L −1 AsHC 360 exposure [15]. Moreover, it has been demonstrated that AsHCs can be ingested by lactating women through seafood and transferred to infants through breast milk.…”

Section: Introductionmentioning

confidence: 97%

AsHC 360 Exposure Influence on Epileptiform Discharges in Hippocampus of Infantile Male Rats In Vitro

Dong,

Zhao,

Tian

et al. 2023

IJMS

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Arsenic-containing hydrocarbons (AsHCs) are typical arsenolipids found in various marine organisms. They can penetrate the blood–brain barrier, specifically affecting synaptic plasticity and the learning and memory ability of hippocampal neurons. Temporal lobe epilepsy often occurs in the hippocampus. Thus, the possible influence of AsHCs exposure to temporal lobe epilepsy garnered attention. The present study investigated the effects of epileptiform discharges (EDs) signals introduced by low-magnesium ACSF in the hippocampus of infantile male rats in vitro, using electrophysiological techniques with multi-electrode arrays under AsHC 360 exposure. In our study of the effects of AsHC 360 on EDs signals, we found that inter-ictal discharges (IIDs) were not significantly impacted. When AsHC 360 was removed, any minor effects observed were reversed. However, when we examined the impact of AsHC 360 on ictal discharges (IDs), distinct patterns emerged based on the concentration levels. For low-concentration groups (5, 20, 60 μg As L−1), both the frequency and duration effects on IDs returned to normal post-elimination of AsHC 360. However, this recovery was not evident for concentrations of 100 μg As L−1 or higher. IDs were only observed in EDs signals during exposures to AsHC 360 concentrations up to 60 μg As L−1. In these conditions, ID frequencies significantly enhanced with the increased of AsHC 360 concentration. At high concentrations of AsHC 360 (≥100 μg As L−1), the transition from IIDs or pre-ictal discharges (PIDs) to IDs was notably inhibited. Additional study on co-exposure of AsHC 360 (100 μg As L−1) and agonist (10 nM (S)-(-)-Bay-K-8644) indicated that the regulation of EDs signals under AsHC 360 exposure could be due to directly interference with the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) expression which influences the binding of excitatory glutamate neurotransmitter to AMPAR. The results suggest that EDs activities in the hippocampus of infantile Sprague Dawley rats are concentration-dependent on AsHC 360 exposure. Thus, it provides a basis for the seafood intake with AsHCs for epileptic patients and those with potential seizures.

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Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat

Cited by 13 publications

References 49 publications

Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression

Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and immune recognition suppression

Using multielectrode arrays to investigate neurodegenerative effects of the amyloid-beta peptide

AsHC 360 Exposure Influence on Epileptiform Discharges in Hippocampus of Infantile Male Rats In Vitro

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