Effect of Arsenic Exposure on Alveolar Macrophage Function

Lantz, R. Clark; Parliman, G.; Chen, Guan Jie; Carter, D. E.

doi:10.1006/enrs.1994.1073

Cited by 48 publications

(13 citation statements)

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“…Arsenate which is in the pentavalent state (As(V)) is also considered to be toxic and carcinogen to human. Arsenate is thought to elicit acute toxicity via different mechanisms where arsenate mimics phosphate and interferes with the adenosine triphosphate (ATP) production in the mitochondria [3].…”

Section: Introductionmentioning

confidence: 99%

Removal of Cr(VI) and As(V) from aqueous solutions by HDTMA-modified zeolite Y

Yusof¹,

Malek²

2009

Journal of Hazardous Materials

293

113

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Section: Introductionmentioning

confidence: 99%

Removal of Cr(VI) and As(V) from aqueous solutions by HDTMA-modified zeolite Y

Yusof¹,

Malek²

2009

Journal of Hazardous Materials

293

113

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“…Bioassay of TNF-· in the CSF utilized the fibrosarcoma cell line, WEHI 164 subclone 13 (Dr. Andres Waage, University of Trondheim, Norway) [27] with modifications as previously described [28].…”

Section: Methodsmentioning

confidence: 99%

Clearance of [<sup>125</sup>I]-Tumor Necrosis Factor-α from the Brain into the Blood after Intracerebroventricular Injection in Rats

Chen¹,

Reichlin²

1998

Neuroimmunomodulation

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To test the hypothesis that brain to blood clearance is a mechanism by which brain inflammation and damage can increase circulating acute phase cytokines, rate of transfer of [¹²⁵I]-tumor necrosis factor-α ([¹²⁵I]-TNF) from brain to blood was determined. Acid precipitable [¹²⁵I]-TNF appeared in peripheral blood within 5 min of intracerebroventricular (i.c.v.) injection and was cleared from brain to blood following first order kinetics at a fractional rate of 0.01123 ± 0.0030/min, a value virtually identical with a previously determined clearance rate of [¹²⁵I]-IL-6. Area under blood concentration curve compared with that after intravenous injection shows that 31.6 ± 5.8% of the intracerebral dose reached peripheral blood in 4 h. Elevated ratios of superior sagittal sinus to aortic blood radioactivity concentration at 1 and 3 h (1.48 ± 0.26, p = 0.042; 1.95 ± 0.39, p = 0.026, respectively) indicate that TNF-α drains from brain at least in part via the sagittal sinus. Escherichia coli lipopolysaccharide i.c.v. injection increased the rate of brain efflux of TNF-α.

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“…Contrary to the commonly-observed response by arsenic-exposed HBE and HPF cells, AM cells typically exhibit a dose-dependent reduction in ROS production in the presence of arsenic [128,185,[205][206][207][208]. Soluble trivalent arsenic was notably more potent at inhibiting ROS production than the corresponding pentavalent form, with superoxide inhibition occurring at respective concentrations of 0.1 and 1 µg/mL [208].…”

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funcmentioning

confidence: 59%

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

et al. 2014

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Arsenic in dust and aerosol generated by mining, mineral processing and metallurgical extraction industries, is a serious threat to human populations throughout the world. Major sources of contamination include smelting operations, coal combustion, hard rock mining, as well as their associated waste products, including fly ash, mine wastes and tailings. The number of uncontained arsenic-rich mine waste sites throughout the world is of growing concern, as is the number of people at risk of exposure. Inhalation exposures to arsenic-bearing dusts and aerosol, in both occupational and environmental settings, have been definitively linked to increased systemic uptake, as well as carcinogenic and non-carcinogenic health outcomes. It is therefore becoming increasingly important to identify human populations and sensitive sub-populations at risk of exposure, and to better understand the modes of action for pulmonary arsenic toxicity and carcinogenesis. In this paper we explore the contribution of smelting, coal combustion, hard rock mining and their associated waste products to atmospheric arsenic. We also report on the current understanding of the health effects of inhaled arsenic, citing results from various toxicological, biomedical and epidemiological studies. This review is particularly aimed at OPEN ACCESSGeosciences 2014, 4 129 those researchers engaged in the distinct, but complementary areas of arsenic research within the multidisciplinary field of medical geology.Arsenic is the 20th most abundant element in the earth's crust and may be released into the atmosphere as a result of natural processes and anthropogenic activities [1]. Environmental arsenic is released via chemical and physical weathering processes, biological activity and volcanic emissions, while anthropogenic sources include mining, metal smelting and burning of coal. Annual global arsenic emissions are estimated to be 24,000 t [2], with around 60% originating from copper smelting and coal combustion alone [3]. In some urban and highly industrialized areas, less than 2% of the atmospheric arsenic inputs originate from natural sources [3].Emissions of arsenic-bearing particulate matter (PM) are of particular concern for human populations living in proximity to an emission source. Arsenic and inorganic arsenic compounds are classified as Group 1 carcinogens and are associated with cancers of the lung, bladder, kidney, skin, liver and prostate [2]. It should be noted that within the general population, inhalation is only considered a minor exposure pathway for inorganic arsenic compounds, and ingestion is considered the primary exposure pathway [2]. However, populations living in the vicinity of an arsenic emission source have an increased risk of additional exposure through inhalation of arsenic-contaminated particulates [4][5][6][7][8][9].Despite their substantial contribution to global atmospheric arsenic species, mining operations play an understudied role in the generation of contaminated dust and aerosols [10]. To identify some of the emerging ...

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Effect of Arsenic Exposure on Alveolar Macrophage Function

Cited by 48 publications

References 0 publications

Removal of Cr(VI) and As(V) from aqueous solutions by HDTMA-modified zeolite Y

Removal of Cr(VI) and As(V) from aqueous solutions by HDTMA-modified zeolite Y

Clearance of [<sup>125</sup>I]-Tumor Necrosis Factor-α from the Brain into the Blood after Intracerebroventricular Injection in Rats

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

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