Effect of Artemisia Aucheri.L and Bupivacaine Encapsulated Nanoparticles on Nociceptive Pain

Moradkhani, Mahmoud Reza; Karimi, Arash

doi:10.1055/a-0825-6487

Cited by 4 publications

(10 citation statements)

References 22 publications

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“…Bupivacaine has positive results in longer operative contexts (more than 40 minutes in duration) and with a lower association of analgesics. This is because bupivacaine prevented peripheral nerve sensitization, resulting in postoperative pain reduction [24]. Furthermore, the literature describes that prescribing bupivacaine is safe to attempt to alleviate chronic pain from AIP [25,26].…”

Section: Discussionmentioning

confidence: 99%

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Use of intrathecal drug infusion pump with combined morphine and bupivacaine medication for the treatment of abdominal pain due to Acute Intermittent Porphyria (AIP)

Oliveira¹,

Souza²,

Andrade³

et al. 2022

BJCR

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Porphyrias consist of nine genetic disorders, acquired or congenital, resulting from failures in the biosynthesis process of the heme group, resulting in the accumulation of metabolic intermediates in the human body, causing toxicity. We describe a case of a 32-years-old Woman presented with severe and continual abdominal pain, presenting a visual analog scale (VAS) score of 9-10, described by the patient as the worst pain she has ever felt in her life, colic type in the mesogastric area and that radiated throughout the entire abdomen for six months. Due to the presented condition, she underwent appendectomy and cholecystectomy procedures, being later diagnosed with acute intermittent porphyria (AIP). It is important to highlight that some manifestations resulting from AIP are similar to Acute Abdomen. This is a clinical condition characterized by sudden or progressive abdominal pain, which usually requires an emergency surgical procedure to resolve the condition. The diagnosis of AIP is quite complex, and it can easily cause misdiagnoses, as in the present case report, in which the patient was mistakenly submitted to appendectomy and cholecystectomy procedures, due to the symptom of severe abdominal pain, which could lead to exposure her to iatrogenic damage.

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Section: Discussionmentioning

confidence: 99%

“…However, studies have shown that bupivacaine is not efficient in reducing short-term pain [27]. Furthermore, there is no evidence capable of demonstrating the efficacy of the routine use of bupivacaine or any advantage of this drug when compared to other local anesthetics [23,24].…”

Section: Discussionmentioning

confidence: 99%

Use of intrathecal drug infusion pump with combined morphine and bupivacaine medication for the treatment of abdominal pain due to Acute Intermittent Porphyria (AIP)

Oliveira¹,

Souza²,

Andrade³

et al. 2022

BJCR

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“…The most developed and studied formulations are nanoemulsions [ 9 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ], followed by liposomes [ 10 , 24 , 25 , 26 , 27 ], and, finally, nanoparticles [ 11 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. In general, the papers have similar developments: characterization of the formulation through tests that measure particle size, PDI, and zeta potential.…”

Section: Literature Searchmentioning

confidence: 99%

“…In general, the papers have similar developments: characterization of the formulation through tests that measure particle size, PDI, and zeta potential. Electron microscopy also uses physicochemical characterization, although not in all studies [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 25 , 27 , 33 ]. Some papers did not develop stability studies of the formulations developed, which is an important parameter during the product development process.…”

Section: Literature Searchmentioning

confidence: 99%

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Nanotechnology Promoting the Development of Products from the Biodiversity of the Asteraceae Family

et al. 2023

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Biodiversity is a hallmark of the Asteraceae family. Several species are known for their pharmacological potential. The search for new substances has permeated the chemistry of natural products for years. However, the development of a final product is still a challenge. Plant extracts have physicochemical characteristics that sometimes hinder administration, requiring a formulation. In this context, nanotechnology emerges as a tool to improve the pharmacokinetic parameters of several pharmacologically active substances. Nanoemulsions, liposomes, and nanoparticles are used to carry the active ingredients and thus improve therapeutic action, especially for substances with solubility and absorption problems. This paper aimed at compiling all the studies that used nanotechnology to develop formulations from species of the Asteraceae family from 2010 to 2021 in a literature review. The search showed that nanoemulsions are the most developed formulation associated with essential oils. The use of nanotechnology promoted an improvement in the pharmacokinetic parameters of active substances.

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Comparison between ketamine and propofol combined against propofol alone for brachial plexus nerve block in open fixation of forearm fracture: A randomized controlled trial

Moradkhani

Shabaninia

Vahabi

2020

International Journal of Surgery Open

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Background: General anesthesia has been successfully replaced by various nervous block for surgeries. Objective: The purpose of this study was to examine the combined effect of ketamine and propofol for brachial plexus block. Method: In this double-blind randomized trial, 64 patients who underwent open fixation for forearm fracture were randomly assigned to group A (n = 32); comprising of patients who received both propofol (200 mg) and ketamine (50 mg) or group B (n = 32) who received only propofol (200 mg). The infusion was controlled in the groups to induce light-to-moderate sedation. The visual analogue scale (VAS) was used to evaluate pain in the groups. Additionally, parameters such as nausea and vomiting, patients’ satisfaction, blood pressure, heart rate, hallucination and the time of recovery were compared among the groups. Result: Due to the failure of nerve block, 7 patients were excluded from the study. A total of 64 patients were equally divided into two groups. Pain, nausea, vomiting, hallucination and patients’ satisfaction were not statistically different among the two groups. Whereas, changes in the blood pressure and heart rate were lesser in Ketamine-propofol group and however, were not reported to be statistically significant. Conclusion: Admixture of ketofol, containing a small dose of ketamine, is not an appropriate analgesic adjunct for upper arm nerve block, however, it does not increase the incidence of nausea, vomiting and hallucination. Highlights:

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Effect of Artemisia Aucheri.L and Bupivacaine Encapsulated Nanoparticles on Nociceptive Pain

Cited by 4 publications

References 22 publications

Use of intrathecal drug infusion pump with combined morphine and bupivacaine medication for the treatment of abdominal pain due to Acute Intermittent Porphyria (AIP)

Use of intrathecal drug infusion pump with combined morphine and bupivacaine medication for the treatment of abdominal pain due to Acute Intermittent Porphyria (AIP)

Nanotechnology Promoting the Development of Products from the Biodiversity of the Asteraceae Family

Comparison between ketamine and propofol combined against propofol alone for brachial plexus nerve block in open fixation of forearm fracture: A randomized controlled trial

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