Effect of arterial hypertension on chronic urticaria duration

Nebiolo, Franco; Bergia, Roberta; Bommarito, Luisa; Bugiani, Massimiliano; Heffler, Enrico; Carosso, Aurelia; Castiglioni, Gloria; Guida, Giuseppe; Badiu, Iuliana; Pizzimenti, Stefano; Mietta, Sabrina; Ferrero, Nicoletta; Rolla, Giovanni

doi:10.1016/s1081-1206(10)60360-2

Cited by 59 publications

(75 citation statements)

References 24 publications

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“…Twelve articles reported the association between autologous serum skin test (ASST) and CSU duration [2,3,4,5,6,7,8,9,10,11,12,13]. The frequency of ASST-positive results varied from 24.7 to 65.5%, in accordance with previous data in the literature [14,15].…”

Section: Resultssupporting

confidence: 77%

“…Two articles [5,7] reported the association between the presence of angioedema and antinuclear antibodies (ANA) with CSU duration. The frequency of angioedema was 40% (56/139) [5] and 39.9% (91/228) [7].…”

Section: Resultsmentioning

confidence: 99%

“…The frequency of angioedema was 40% (56/139) [5] and 39.9% (91/228) [7]. Although the prevalence of concomitant angioedema was similar, results were conflicting, with the studies reporting either no association [7] or a significant association [5]. …”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of ANA was 4% [5] and 21% [7]. Neither article had evidence of a statistically significant association between ANA and CSU duration.…”

Section: Resultsmentioning

confidence: 99%

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Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

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Background: Although some authors have already evaluated the predictive value of various parameters regarding the duration of chronic spontaneous urticaria (CSU), it remains uncertain which ones have importance in clinical practice as prognostic factors that indeed enable prediction. Similarly, some authors have investigated parameters that might be related to severe cases of CSU. However, the results of studies evaluating several parameters as markers of disease severity are fragmented. Thus, we performed a systematic review to summarize the findings of studies investigating the parameters associated with CSU duration and severity. Methods: Two authors independently searched PubMed until June 2012 for observational retrospective or prospective studies addressing clinical or laboratory parameters associated with disease duration or severity in CSU patients. Results: We found 1,136 potentially relevant published papers related to the subject, 34 of which were included in the systematic review. A total of 16, 6 and 12 articles evaluated CSU parameters on severity, duration or both, respectively. Conclusions: Our findings suggest that disease severity might predict CSU duration. Similarly, evidence suggests that plasma levels of prothrombin fragment 1 + 2, D-dimer and C-reactive protein may function as markers of CSU severity.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The prevalence of ANA was 4% [5] and 21% [7]. Neither article had evidence of a statistically significant association between ANA and CSU duration.…”

Section: Resultsmentioning

confidence: 99%

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Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Rabelo-Filardi

Daltro-Oliveira

Campos

2013

Int Arch Allergy Immunol

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“…The analysis of patients with atopic dermatitis matched by sex, age group and index year disclosed that atopic dermatitis was not associated with a previous hyperlipidemia diagnosis, ruling out a relationship of this diagnosis with inflammatory skin diseases in general. A prospective study in a cohort of 228 consecutive adults with moderate to severe CSU revealed that blood hypertension was associated with extended duration of CSU and influenced disease remission (23). In particular, persistence of CSU after 5 years was still detected in 74% and 54% of CSU patients with and without hypertension, respectively.…”

Section: Metabolic Syndromementioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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Summary Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile

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Chronic spontaneous urticaria: Evidence of systemic microcirculatory changes

Mostmans,

Maurer,

Richert

et al. 2024

Clinical & Translational All

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BackgroundChronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease where activation of endothelial cells (ECs) at sites of skin lesions leads to increased blood flow, leakage of fluid into the skin, cellular infiltration, and vascular remodeling. To understand the disease duration and the sometimes vague systemic symptoms accompanying flares, the objective of this study was to examine if CSU comes with systemic vascular changes at the microcirculatory level.MethodsWe investigated CSU patients (n = 49) and healthy controls (HCs, n = 44) for microcirculatory differences by nailfold videocapillaroscopy (NVC) and for blood levels of the soluble EC biomarkers serum vascular endothelial growth factor (VEGF), soluble E‐selectin, and stem cell factor (SCF). Patients were also assessed for clinical characteristics, disease activity, and markers of autoimmune CSU (aiCSU).ResultsCSU patients had significantly lower capillary density, more capillary malformations, and more irregular capillary dilations than HCs on NVC. Serum levels of VEGF, soluble E selectin and SCF were similar in CSU patients and HCs. CSU patients with higher VEGF levels had significantly more abnormal capillaries. Patients with markers of aiCSU, that is, low IgE levels or increased anti‐TPO levels, had significantly more capillaries and less capillary dilations than those without.ConclusionOur results suggest that CSU comes with systemic microcirculatory changes, which may be driven, in part, by VEGF.

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Effect of arterial hypertension on chronic urticaria duration

Cited by 59 publications

References 24 publications

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

Parameters Associated with Chronic Spontaneous Urticaria Duration and Severity: A Systematic Review

The link between chronic spontaneous urticaria and metabolic syndrome

Chronic spontaneous urticaria: Evidence of systemic microcirculatory changes

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