Effect of arterial occlusion on responses of group III  and IV afferents to dynamic exercise

Adreani, Christine M.; Kaufman, Marc P.

doi:10.1152/jappl.1998.84.6.1827

Cited by 109 publications

(106 citation statements)

References 16 publications

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“…most part confirmed these findings. In addition, the present study has shown for the first time that postexercise circulatory occlusion, a maneuver that was not performed in our previous studies (1,2,25), significantly increased over (preexercise) baseline levels the discharge of group IV, but not group III, afferents.…”

Section: Discussionsupporting

confidence: 46%

“…We (1,2,25) have shown previously that dynamic exercise increased the activity of group III and IV afferents in decerebrated cats. This increase displayed two characteristics.…”

Section: Discussionmentioning

confidence: 80%

“…The second mechanism, the exercise pressor reflex, arises from mechanical and metabolic stimuli that activate group III and IV afferents in the working muscles (14,19,22). Mechanical stimuli appear to be transduced primarily by group III muscle afferents, whereas metabolic stimuli appear to be transduced primarily by group IV muscle afferents (1,2,10).…”

mentioning

confidence: 99%

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Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats

Hayes¹,

Kindig²,

Kaufman

2006

American Journal of Physiology-Heart and Circulatory Physiology

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Cyclooxygenase products accumulate in statically contracting muscles to stimulate group III and IV afferents. The role played by these products in stimulating thin fiber muscle afferents during dynamic exercise is unknown. Therefore, in decerebrated cats, we recorded the responses of 17 group III and 12 group IV triceps surae muscle afferents to dynamic exercise, evoked by stimulation of the mesencephalic locomotor region. Each afferent was tested while the muscles were freely perfused and while the circulation to the muscles was occluded. The increases in group III and IV afferent activity during dynamic exercise while the circulation to the muscles was occluded were greater than those during exercise while the muscles were freely perfused ( P < 0.01). Indomethacin (5 mg/kg iv), a cyclooxygenase blocker, reduced the responses to dynamic exercise of the group III afferents by 42% when the circulation to the triceps surae muscles was occluded ( P < 0.001) and by 29% when the circulation was not occluded ( P = 0.004). Likewise, indomethacin reduced the responses to dynamic exercise of group IV afferents by 34% when the circulation was occluded ( P < 0.001) and by 18% when the circulation was not occluded ( P = 0.026). Before indomethacin, the activity of the group IV, but not group III, afferents was significantly higher during postexercise circulatory occlusion than during rest ( P < 0.05). After indomethacin, however, group IV activity during postexercise circulatory occlusion was not significantly different from group IV activity during rest. Our data suggest that cyclooxygenase products play a role both in sensitizing group III and IV afferents during exercise and in stimulating group IV afferents during postexercise circulatory occlusion.

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Section: Discussionsupporting

confidence: 46%

“…We (1,2,25) have shown previously that dynamic exercise increased the activity of group III and IV afferents in decerebrated cats. This increase displayed two characteristics.…”

Section: Discussionmentioning

confidence: 80%

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Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats

Hayes¹,

Kindig²,

Kaufman

2006

American Journal of Physiology-Heart and Circulatory Physiology

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“…The former involves muscle metaboreceptor and mechanoreceptor afferent signals integrated at the level of the hypothalamus or medulla oblongata, while the latter involves integration of the two afferents (e.g., sensitization) at the activating muscle level (1,30). When muscle mechanoreceptors and metaboreceptors are activated in the same muscle, both central and peripheral integration would induce physiological responses.…”

mentioning

confidence: 99%

Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Amano

Ichinose

Nishiyasu

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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-Activation of muscle metaboreceptors and mechanoreceptors has been shown to independently influence the sweating response, while their integrative control effects remain unclear. We examined the sweating response when the two muscle receptors are concurrently activated in different limbs, as well as the blood pressure response. In total, 27 young males performed passive calf muscle stretches (muscle mechanoreceptor activation) for 30 s in a semisupine position with and without postisometric handgrip exercise muscle ischemia (PEMI, muscle metaboreceptor activation) at exercise intensities of 35 and 50% of maximum voluntary contraction (MVC) under hot conditions (ambient temperature, 35°C, relative humidity, 50%). Passive calf muscle stretching alone increased the mean sweating rate significantly on the forehead, chest, and thigh (SRmean) and mean arterial blood pressure (MAP), but not the heart rate (HR), from prestretching levels by 0.04 Ϯ 0.01 mg·cm 2 ·min Ϫ1 , 4.0 Ϯ 1.3 mmHg (P Ͻ 0.05), and Ϫ1.0 Ϯ 0.5 beats/min (P Ͼ 0.05), respectively. The SRmean and MAP during PEMI were significantly higher than those at rest. The passive calf muscle stretch during PEMI increased MAP significantly by 3.4 Ϯ 1.0 and 2.0 Ϯ 0.7 mmHg for 35 and 50% of MVC, respectively (P Ͻ 0.05), but not that of SRmean or HR at either exercise intensity. These results suggest that sweating and blood pressure responses to concurrent activation of the two muscle receptors in different limbs differ and that the influence of calf muscle mechanoreceptor activation alone on the sweating response disappears during forearm muscle metaboreceptor activation. nonthermal factors; group III and IV muscle afferents; thermoregulation; sympathetic nervous system; sweat gland THE SWEATING RESPONSE DURING exercise is controlled not only by core and skin temperatures (thermal factors) but also by exercise-related (nonthermal) factors, such as afferent inputs from working muscles. It is well known that group III muscle afferents are stimulated predominantly by mechanically sensitive muscle mechanoreceptors, whereas group IV muscle afferents are stimulated mainly by chemically sensitive muscle metaboreceptors. Activation of muscle metaboreceptors by postexercise muscle ischemia (PEMI) under normothermic and mildly hot conditions induces sweating (2, 4, 22, 38). Additionally, Kondo et al. (23) reported that activating the muscle mechanoreceptors by passive limb movement for 2 min evoked slight sweating under hot conditions. Furthermore, the muscle mechanoreflex increases the sweating response during passive recovery (passive limb movement using a tandem ergometer) compared with inactive recovery (resting) after cycling (20,39). These studies suggest that the isolated activation of muscle metaboreceptors and mechanoreceptors can independently affect sweating responses. However, the sweating response is presumably controlled by integrative mechanisms, based on afferent signals from muscle metaboreceptors and mechanoreceptors because physiological integrative control h...

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“…However, although injection of an acid solution can stimulate both the group III and IV muscle afferent fibres, there is still no evidence that relatively small changes in muscle pH, such as those resulting from the Haldane effect in fluid with a high buffering capacity, could represent a source of stimulation of these thin muscle afferents during an exercise of light or moderate intensity. For instance, complete occlusion of the hindlimb circulation seems to have a very small stimulatory effect on muscle group IV, and no effect on group III, endings of the triceps in the cat during walking (Adreani & Kaufman, 1998). Moreover, since the study by Dejours et al (1955), there have been consistent reports that trapping all the metabolic-like products of exercise -including H¤ -in the post-exercising muscles does not stimulate ventilation.…”

Section: Mechanisms Of Oµ-induced ýE Stimulation During Exercisementioning

confidence: 95%

Stimulation of ventilation by normobaric hyperoxia in exercising dogs

Haouzi¹,

Allioui²,

Gille³

et al. 2000

Exp. Physiol.

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Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise

Cited by 109 publications

References 16 publications

Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats

Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats

Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans

Stimulation of ventilation by normobaric hyperoxia in exercising dogs

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