Effect of arthrocentesis and sodium hyaluronate injection on nitrite, nitrate, and thiobarbituric acid-reactive substance levels in the synovial fluid

Treatment of Temporomandibular Joint Osteoarthritis by Using Arthrocentesis and Hyaluronic Acid Injections: Modified Protocol

“…But, they concluded that Arthrocentesis with hyaluronic acid injection seemed to be superior to Arthrocentesis alone especially in patients with TMJ Closed Lock and this was ascribed to a faster and longer effect of hyaluronic acid on pain relief. Besides, intraarticular injection of hyaluronic acid caused significant reduction in the nitric oxide (NO) level in the synovial fluid, whereas no significant decrease in these levels was found in patients receiving Arthrocentesis only [14].…”

Oxidant and anti‐oxidant systems of synovial fluid from patients with knee post‐traumatic arthritis

“…OH may inhibit cartilage proteoglycan synthesis, e.g., by interfering with ATP synthesis, in part by inhibiting the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase in chondrocytes. [45][46][47][48] Alpaslan et al 49 found that intraarticular use of hyaluronan significantly decreased concentration This would suggest that membrane lipids are only one of the possible targets of oxidative damage, and compounds of SF such as hyaluronic acid would be more susceptible to oxidative stress. The production of ROS in synovial fluid is difficult to detect because ROS are extremely labile.…”

“…Chronic joint diseases may deplete anti-oxidant defenses, whereas acute post-traumatic arthritis may upregulate them. 49,52 The samples used in the present study represent an acute PA with inflammatory exudates in the knee joints, especially in HA subgroup.…”

“…In SF, these anti-oxidant enzymes often coexist. 49 The absence or dysfunction of some of these antioxidant enzymes make the components of the joint cavity vulnerable to oxidative damage. 51 We hypothesized that patients with knee posttraumatic arthritis, associated or not to hemarthrosis, display a decreased anti-oxidant system.…”

Temporomandi̇bular Eklem Osteoartri̇tli̇ Hastalarda Artrosentezi̇ Taki̇ben Yapilan Trombosi̇tten Zengi̇n Plazma, Hyaluroni̇k Asi̇t Ve Korti̇kosteroi̇d Enjeksi̇yonlarinin Temporomandi̇bular Eklem Palpasyonunda Oluşan Ağriya Etki̇leri̇ni̇n Karşilaştirilmasi

“…1,2 Artrosentez işlemi eklem içerisindeki enflamatuar ürünleri uzaklaştırıp ağrıyı azaltmakta ve fonksiyonel iyileşme göstermektedir. 4 Trombositten zengin plazma (PRP) deneklerden alınan tam kanın yüksek oranda santrifüj edilmesi ile elde edilen ve tam kandan 3-8 kat kadar fazla konsantrasyonda, çok sayıda büyüme faktörü içeren trombositlerinotolog solüsyonu olarak tanımlanmaktadır. PRP hücrelerin proliferasyonu, migrasyonu ve farklılaş-ması üzerinde etki ederek yeni kemik ve kartilaj üze-rinde iyileştirici potansiyel etki gösterir, kondrojenik farklılaşma, matrix üretimi ve doku remodelasyonu üzerinde etki oluşturur.…”