Effect of Asbestos Dust Inhalation on Lung Function

Kleinfeld, Morris; Messite, Jacqueline; Kooyman, Olive; Sarfaty, J.

doi:10.1080/00039896.1966.10664474

Cited by 21 publications

(3 citation statements)

References 7 publications

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“…2). Recent studies of lung rales [Thacker and Kraman, 19821 have documented that normal young nonsmokers do not have rales during inspiration from functional residual capacity, which is in agreement with the low incidence of such findings on control subjects of epidemiological surveys [hathart, 1968;Kleinfeld et al, 1966;Shirai et al, 19811. However, in matched control workers, some of whom were cigarette smokers, the incidence of bilateral lung rales was present in some 5-11 %, and this agrees with our data on group A and B workers ( Table I).…”

Section: Discussionmentioning

confidence: 64%

Clinical features to stage alveolitis in asbestos workers

Bégin

Cantin

Berthiaume

et al. 1985

American J Industrial Med

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To analyze the clinical features of asbestos-induced alveolitis and stage its activity, we evaluated 217 asbestos workers by the usual clinical, radiological, and functional parameters and computerized gallium 67(Ga) lung scan; we obtained bronchoalveolar lavage (BAL) in 33 and lung biopsy in 6. In addition, we scored the profusion of lung rales and correlated it with other parameters of severity of asbestosis. In the 55 workers without asbestosis and normal 67Ga scan, BAL analyses were comparable to those of controls. Of the 56 without asbestosis but increased 67Ga lung uptake, BAL analyses in 8 documented a predominantly macrophagic alveolitis (confirmed on lung biopsy in 3), with the highest levels of BAL fibronectin. In the 106 workers with asbestosis, 67Ga lung uptake was increased in 75; BAL in 17 demonstrated a macrophagic and neutrophilic alveolitis with elevated fibronectin levels. Lung biopsy in 3 of the latter workers documented peribronchiolar fibrosing alveolitis. Rale scores in all workers or in those without asbestosis did not correlate with 67Ga scores; they correlated fairly well with profusion of parenchymal opacities (Rs = 0.42) and rigidity of the lung pressure-volume curve (Rs = 0.39). Thus, 67Ga lung uptake is an early indicator of chronic macrophagic alveolitis in asbestos workers, which usually progresses to asbestosis. In the disease, profusion of lung rales constitutes a simple clinical mode of assessment of disease severity that correlates better with radiological and functional parameters than with parameters of alveolitis.

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Section: Discussionmentioning

confidence: 64%

Clinical features to stage alveolitis in asbestos workers

Bégin

Cantin

Berthiaume

et al. 1985

American J Industrial Med

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“…It is important to note that they were able to compare this with a 4.2% prevalence in control subjects. Similarly, Vigliani 13 reported 13% and Kleinfield and coworkers 14 reported 16%. The use of auscultation was made even more objective when the observer auscultating was unaware of exposure history.…”

Section: Lung Auscultation In Asbestosismentioning

confidence: 85%

Chest Auscultation in Occupational Lung Disease

Murphy¹

1986

Semin Respir Crit Care Med

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“…Study Area. Studies of talc workers near Gouverneur, New York, starting more than a half century ago reported high incidences of diseases similar to diseases of asbestos workers ( − ). Other investigators have contended that these abnormalities were not directly related to talc ( , ).…”

Section: Methodsmentioning

confidence: 99%

Reconstruction of a Century of Airborne Asbestos Concentrations

Webber

Jackson

Parekh

et al. 2003

Environ. Sci. Technol.

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Airborne asbestos concentrations have been reconstructed for the entire 20th century for the first time through a combination of paleolimnological methods, particle-separation techniques, and analytical transmission electron microscopy. Pb concentrations and respirable aerosol mass concentrations in air and sediments yielded collection efficiencies of approximately 3000 m3 of air per gram of lake sediment. Airborne concentrations of chrysotile, the most common type of asbestos, reconstructed from control lake sediments echoed chrysotile's usage during the 20th century, with the highest concentrations mid-century (approximately 0.1 fibers/cm3) and then decreasing in the last quarter century. Reconstructed airborne concentrations of anthophyllite asbestos, a byproduct of local talc mining and milling, increased from <0.004 to 0.022 fibers/cm3 from 1846 to 1967. These anthophyllite concentrations during the approximately 100-year period of talc mining correlated well (r2 = 0.80, p < 0.01) with annual production of local talc and were much higher (p = 0.004) than concurrent concentrations in a control lake located upwind of the mines and mills. All of the chrysotile and more than 70% of the anthophyllite asbestos fibers were too narrow to be detected by phase-contrast light microscopy, the method used to measure airborne fiber concentrations before approximately 1980.

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Effect of Asbestos Dust Inhalation on Lung Function

Cited by 21 publications

References 7 publications

Clinical features to stage alveolitis in asbestos workers

Clinical features to stage alveolitis in asbestos workers

Chest Auscultation in Occupational Lung Disease

Reconstruction of a Century of Airborne Asbestos Concentrations

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