Effect of Ascaris Extract Applied Intravenously, on Segment Bronchus and the Influence of Ipsilateral Vagus Blockade

Zimmermann, I.; Islam, M. S.; Ulmer, W. T.

doi:10.1159/000193742

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…The reaction of respiratory airways to local application of his tamine and Ascaris extract on the bronchopulmonary segment and thus the effect of ipsilateral vagus blockade on this reaction was also studied before [6,12].…”

Section: Discussionmentioning

confidence: 99%

“…Bilateral vagotomy is impracticable for prolonged experiments. The sensitizing effect of local application of histamine to a circumscribed area in the trachea or in one of the segmental bronchi to acetylcholine aerosol and the role of unilat eral vagotomy on this effect has been studied by Islam and U lmer [4] and Islam et al [6].The role of ipsilateral vagus blockade on bronchoconstriction effects produced by local application on segmental bronchi of Ascaris extract has also been studied before [12]. …”

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confidence: 99%

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Effect of Unilateral Vagus Blockade on Antigen-Induced Airway Obstruction

Zimmermann¹,

Islam²,

Ulmer³

1976

Respiration

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Respiratory hyper sensitivity and the effect of unilateral vagus blockade on the same, after the use of Ascaris extract aerosol, are studied in three boxer dogs with spontaneous reactivity to this aerosol. The dogs were exposed initially to Ascaris extract aerosol, and this exposure was repeated after unilateral vagus blockade and after its lavage. The principal parameters, ΔP_oes (mm Hg)/100ml TV, are given as a measurement of airway flow resistance and respiratory rates. The spontaneous respiratory distress observed in all the animals after exposure to the mentioned aerosol was avoided with unilateral blockade of the nervus vagus.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Unilateral Vagus Blockade on Antigen-Induced Airway Obstruction

Zimmermann¹,

Islam²,

Ulmer³

1976

Respiration

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“…Otherwise, asthma model has been pro duced in dogs and monkeys by exposing them to aerosol challenge with Ascaris suum ex tract [Goldeta/., 1972b;Weiszeretat., 1968] and different methods of unilateral or bilat eral central vagus blockade have been stud ied before in this experimental asthma [ Gold et al, 1972a;Zimmermann et a!., 1976b].…”

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confidence: 99%

Effect of Unilateral Vagus Blockade on Allergen-Induced Airway Obstruction

Zimmermann¹,

Ulmer²

1977

Respiration

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Unilateral application of ascaris extract on segment bronchus as the influence of contralateral vagus blockade on reflex bronchoconstriction was studied on four boxer dogs in a first group (A) of experiments: ascaris extract was applied in liquid form directly through a catheter into the right segment bronchus. This application was repeated after contralateral vagus blockade and once more after its lavage. All the animals showed an increase of airway resistance under local application of ascaris extract which could not be avoided by contralateral central vagus blockade. In the second group (B) isolation of unilateral vagus for reproducible performance of blockade as a long-term model was investigated in three boxer dogs for 7 weeks and the influence of this method of unilateral vagus blockade on exposure to allergen aerosol was studied. The unilateral blockade of the nerve vagus was again always successful in decreasing the reflex bronchoconstriction following allergen inhalation. The effect of unilateral section of nervus vagus 3 weeks after this vagotomy was tested on two boxer dogs. Reflex bronchoconstriction following ascaris extract inhalation can be avoided by unilateral section of the nervus vagus the first time after section. Three weeks after this unilateral vagotomy, the reflex bronchoconstriction becomes managed by the remaining vagus trunk to the same degree as observed by bilateral intact vagi.

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“…Allergeninduzierte Atemwegsobstruktion ist in etwa gleich grol3er St~irke von den tieferen Atemwegen wie von dem oberen Tell des Respirationstraktes her aus-16sbar (Zimmermann et al, 1976b(Zimmermann et al, , 1979a. Bei den einzelnen Tieren ist die Empfindlichkeit der getrennten Abschnitte unterschiedlich, wie die Mittelwertkuryen der Abbildungen 2-4 erkennen lassen.…”

Section: Ergebnisseunclassified

Wirkort von ?2-Receptoren stimulierenden Bronchodilatatoren

et al. 1980

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On dogs sensitive against Ascaris suum extract an increase of the airway resistance can be caused by challenge alone on the upper part or the lower part of the airways by Ascaris suum extract. Fenoterol as beta 2-receptor stimulator is capable to decrease this reaction by deposition of this drug on the upper part as on the lower part of the airways. The effect of Fenoterol on the upper part of the airways is much stronger and lasts much longer than on the lower part of the airways or by intravenous route. A direct effect of the beta 2-receptor stimulator Fenoterol on the sensoric part of the reflex way of the reflex bronchoconstriction must be considered. It will be also discussed that the local application of Fenoterol on the upper part of the airways may influence also the reaction of the bronchial muscles in the lower part of the airways without a direct resorptive-systemic effect. The relationship of these findings for the clinical situation on man has to be investigated.

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Effect of Ascaris Extract Applied Intravenously, on Segment Bronchus and the Influence of Ipsilateral Vagus Blockade

Cited by 8 publications

References 7 publications

Effect of Unilateral Vagus Blockade on Antigen-Induced Airway Obstruction

Effect of Unilateral Vagus Blockade on Antigen-Induced Airway Obstruction

Effect of Unilateral Vagus Blockade on Allergen-Induced Airway Obstruction

Wirkort von ?2-Receptoren stimulierenden Bronchodilatatoren

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