Effect of Ascophyllan from Brown Algae Padina tetrastromatica on Inflammation and Oxidative Stress in Carrageenan-Induced Rats

Mohsin, Sahar; Kurup, G. Muraleedhara; Mahadevan, R.

doi:10.1007/s10753-013-9665-4

Cited by 14 publications

(10 citation statements)

References 41 publications

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“…The large quantities of hydrogen peroxide generated are then taken care of by catalase and glutathione peroxidase (GPx) to water. Excessive production of lipid hydroperoxide may also lead to reduced activity of GPx in inflammatory conditions [29]. Besides the enzymatic antioxidants, the level of glutathione, a nonenzymatic reducing agent that traps free radicals and prevents oxidative damage, is also diminished in inflammatory conditions [30].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

Golechha

Sarangal

Ojha

et al. 2014

International Journal of Inflammation

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Emblica officinalis, commonly known as amla in Ayurveda, is unarguably the most important medicinal plant for prevention and treatment of various ailments. The present study investigated the anti-inflammatory activity of hydroalcoholic extract of Emblica officinalis (HAEEO). Acute inflammation in rats was induced by the subplantar injection of carrageenan, histamine, serotonin, and prostaglandin E2 and chronic inflammation was induced by the cotton pellet granuloma. Intraperitoneal (i.p.) administration of HAEEO at all the tested doses (300, 500, and 700 mg/kg) significantly (P < 0.001) inhibited rat paw edema against all phlogistic agents and also reduced granuloma formation. However, at the dose of 700 mg/kg, HAEEO exhibited maximum anti-inflammatory activity in all experimental models, and the effects were comparable to that of the standard anti-inflammatory drugs. Additionally, in paw tissue the antioxidant activity of HAEEO was also measured and it was found that HAEEO significantly (P < 0.001) increased glutathione, superoxide dismutase, and catalase activity and subsequently reduced lipid peroxidation evidenced by reduced malondialdehyde. Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

Golechha

Sarangal

Ojha

et al. 2014

International Journal of Inflammation

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“…15 Ascophyllan, a compound isolated from PT, was reported to show high antioxidant activity. 16,17 However, the brown marine seaweed PT has not been explored for its other bioactive properties.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Anticancer and Genotoxicity Profiles of Green Synthesized and Chemically Synthesized Silver Nanoparticles

Veeragoni

Deshpande

Rachamalla

et al. 2022

ACS Appl. Bio Mater.

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Silver nanoparticles were green synthesized (Ag-PTs) employing the crude extract of Padina tetrastromatica, a marine alga, and their anticancer and safety profile were compared with those of chemically synthesized silver nanoparticles (Ag-NPs) by in vitro and in vivo models. Ag-PT exhibited potent cytotoxicity against B16-F10 (IC50 = 3.29), MCF-7 (IC50 = 4.36), HEPG2 (IC50 =3.89), and HeLa (IC50 = 4.97) cancer cell lines, whereas they exhibited lower toxicity on normal CHO-K1 cells (IC50 = 5.16). The potent anticancer activity of Ag-PTs on cancer cells is due to the liberation of ions from the nanoparticles. Increased ion internalization to the cells promotes reactive oxygen species (ROS) production and ultimately leads to cell death. The in vitro anticancer results and in vivo melanoma tumor regression study showed significant inhibition of melanoma tumor growth due to Ag-PT treatment. Ag-PT is involved in the upregulation of the p53 protein and downregulation of Sox-2 along with the Ki-67 protein. The antitumor effects of Ag-PTs may be due to the additional release of ions at a lower pH of the tumor microenvironment than that of the normal tissue. The results of safety investigations of Ag-PT by studying mitotic chromosome aberrations (CAs), micronucleus (MN) induction, and mitotic index (MI) demonstrated Ag-PT to be less genotoxic compared to Ag-NP. The bioefficacy and toxicology outcomes together demonstrated that the green synthesized silver nanoparticles (Ag-PTs) could be explored to develop a biocompatible, therapeutic agent and a vehicle of drug delivery for various biomedical applications.

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“…Seaweeds have been widely used in pharmaceutical and food industries for decades due to its renewable properties. There are around 10,000 species of seaweeds found worldwide and they are all classified into three major classes which are red algae (Rhodophytes), brown algae (Phaeophytes) and green algae (Chlorophytes) (Mohsin et al, 2013). Seaweeds can be easily found all around the world, especially in Asian countries such as Japan, Philippines, Korea, Malaysia and Indonesia (Wang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Biological and therapeutic potential of the edible brown marine seaweed Padina australis and their pharmacological mechanisms

Chellappan¹,

Chellian²,

Leong³

et al. 2020

JTBC

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Seaweeds have an important place in the ancient systems of medicine. In addition, they also find significant mention in farming and in nutritional diet due to their benefits such as, availability, cheaper price, renewable potential and the advantage of being easily accessible. There are over 10,000 species of seaweeds that reflect their immense diversity. They are further used for both, their flavour and nutritional properties. Edible seaweeds are rich sources of bioactive compounds. In the last three decades, the discovery of metabolites with biological activities from macroalgae has increased significantly. Padina australis has been reported to possess several therapeutic activities including, antioxidant, anti-inflammatory, antibacterial and larvicidal effects. In addition, studies have also reported on the antidiabetic and antihypertensive potential of Padina australis. Till date, there are limited or no scientific reviews that have been published on the pharmacological and therapeutical activities of Padina australis in specific. Thus, there is a need for such a review to appreciate the various biological actions of this potent seaweed. This review, in this direction, attempts to explore the various therapeutic activities of the brown marine seaweed Padina australis, from the current published literature along with their pharmacological and molecular mechanisms, underlying its therapeutic activities. The main limitation of this review is that ancient texts, leisure magazines and traditional manuscripts were not searched.

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Effect of Ascophyllan from Brown Algae Padina tetrastromatica on Inflammation and Oxidative Stress in Carrageenan-Induced Rats

Cited by 14 publications

References 41 publications

Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

Anti-Inflammatory Effect ofEmblica officinalisin Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms

In Vitro and In Vivo Anticancer and Genotoxicity Profiles of Green Synthesized and Chemically Synthesized Silver Nanoparticles

Biological and therapeutic potential of the edible brown marine seaweed Padina australis and their pharmacological mechanisms

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