Effect of ascorbic acid on calcium elimination in humans.

Tsao, Constance S.; Miyashita, Koichi; Leung, Ping Y.

doi:10.3177/jnsv.32.437

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Therefore, the aim of this study was to determine in aged mice the impact of a reduced dietary intake of vitamins A, E, B6, and B12, folate, selenium, and zinc on muscle mass, strength, and physical function over time. Vitamin C, a well‐described antioxidant, was not in scope of the diet intervention because mice can endogenously synthesize vitamin C . In addition, underlying determinants of these physical traits were explored, focusing on muscle force production, muscle mitochondrial density and muscle fibre characterization (i.e.…”

Section: Introductionmentioning

confidence: 99%

Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice

Dijk

Hartog

et al. 2017

J cachexia sarcopenia muscle

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BackgroundInadequate intake of micronutrients with antioxidant properties is common among older adults and has been associated with higher risk of frailty, adverse functional outcome, and impaired muscle health. However, a causal relationship is less well known. The aim was to determine in old mice the impact of reduced dietary intake of vitamins A/E/B6/B12/folate, selenium, and zinc on muscle mass, oxidative capacity, strength, and physical activity (PA) over time.MethodsTwenty‐one‐month‐old male mice were fed either AIN‐93‐M (control) or a diet low in micronutrients with antioxidant properties (=LOWOX‐B: 50% of mouse recommended daily intake of vitamins A, E, B6, and B12, folate, selenium, and zinc) for 4 months. Muscle mass, grip strength, physical activity (PA), and general oxidative status were assessed. Moreover, muscle fatigue was measured of m. extensor digitorum longus (EDL) during an ex vivo moderate exercise protocol. Effects on oxidative capacity [succinate dehydrogenase (SDH) activity], muscle fibre type, number, and fibre cross‐sectional area (fCSA) were assessed on m. plantaris (PL) using histochemistry.ResultsAfter 2 months on the diet, bodyweight of LOWOX‐B mice was lower compared with control (P < 0.0001), mainly due to lower fat mass (P < 0.0001), without significant differences in food intake. After 4 months, oxidative status of LOWOX‐B mice was lower, demonstrated by decreased vitamin E plasma levels (P < 0.05) and increased liver malondialdehyde levels (P = 0.018). PA was lower in LOWOX‐B mice (P < 0.001 vs. control). Muscle mass was not affected, although PL‐fCSA was decreased (~16%; P = 0.028 vs. control). SDH activity and muscle fibre type distribution remained unaffected. In LOWOX‐B mice, EDL force production was decreased by 49.7% at lower stimulation frequencies (P = 0.038), and fatigue resistance was diminished (P = 0.023) compared with control.ConclusionsReduced dietary intake of vitamins A, E, B6, and B12, folate, selenium, and zinc resulted in a lower oxidative capacity and has major impact on muscle health as shown by decreased force production and PA, without effects on muscle mass. The reduced fCSA in combination with similar SDH activity per fibre might explain the reduced oxidative capacity resulting in the increased fatigue after exercise in LOWOX‐B mice.

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Section: Introductionmentioning

confidence: 99%

Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice

Dijk

Hartog

et al. 2017

J cachexia sarcopenia muscle

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Urinary excretion of calcium, dopamine, norepinephrine, and epinephrine in young women following ascorbic acid ingestion

et al. 1992

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Effect of citrate on the urinary excretion of calcium and oxalate: relevance to calcium oxalate nephrolithiasis.

et al. 1989

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Studies in 24 recurrent oxalate stone-formers have shown that values for urinary calcium excretion for this group on at-home diets vary significantly (P less than 0.001) more than values for creatinine excretions. By placing stone-formers on controlled in-hospital diets and measuring their calcium excretions, we were able to predict probable outpatient hypercalciuria (greater than 7.5 mmol/day) with a sensitivity of 95% and a specificity of 95%. In this study, the renal loss of calcium during low-calcium diets was proportional to the absorptive hypercalciuria during high-calcium diets. Calcium loading experiments in fasted stone-formers and normal subjects indicated that citrate, at citrate:calcium molar ratios ranging from 0.12 to 1, stimulated urinary calcium excretion more than did calcium carbonate loading alone. In addition, citrate also significantly (P less than 0.05) increased the excretion of urinary oxalate by two normal subjects for a given load of calcium oxalate. Malabsorption of citrate and possibly other hydroxycarboxylic acids may thus predispose to oxalate nephrolithiasis by promoting calcium and oxalate absorption.

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Effect of ascorbic acid on calcium elimination in humans.

Cited by 4 publications

References 22 publications

Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice

Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice

Urinary excretion of calcium, dopamine, norepinephrine, and epinephrine in young women following ascorbic acid ingestion

Effect of citrate on the urinary excretion of calcium and oxalate: relevance to calcium oxalate nephrolithiasis.

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