Effect of Ascorbic Acid on Renal Excretion of Lead in the Rat

Niazi, Sarfaraz K.; Lim, Josephine; Bederka, John P.

doi:10.1002/jps.2600711033

Cited by 9 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported protective effects of vitamin C against intoxication with lead (Houston & Johnson, 2000;Shalan et al, 2005). Studies in rats have demonstrated that vitamin C could reduce the gastrointestinal lead absorption (Morton et al, 1985) and promotes the renal excretion of lead (Niazi et al, 1982). In addition, there is evidence that vitamin C in the duodenum results in the reduction of ferric iron to the ferrous state, which competes with lead for intestinal transporter (Morton et al, 1985;Suzuki & Yoshida, 1979).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Heidarian

Rafieian-Kopaei

2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Artichoke, Cynara scolymus L. (Asteraceae), has many natural antioxidants and multiple pharmacological actions. Recent studies have shown that it has antitoxic activity. Objective: Lead (Pb) is a dangerous environmental toxicant that induces a broad range of dysfunctions in human. This study evaluated the protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with lead-containing diet. Materials and methods: Thirty-two rats were randomly divided into four groups. The first (control) group received standard diet. The second, third and fourth groups received 500 mg lead/kg diet, 500 mg lead/kg diet plus 300 mg/kg b.w. artichoke extract daily, and 500 mg lead/ kg diet plus 1 mg vitamin C/100 g b.w. daily for 6 weeks, respectively. Serum lead, lipoprotein profile, ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), malondialdehyde (MDA) and liver histopathology assessments were conducted. Results: Serum lead, triglyceride (TG), VLDL, ALT, AST, ALP and MDA levels decreased significantly (p50.05) in the artichoke-treated group (35.85, 38.26, 38.38, 21.90, 12.81, 26.86 and 46.91%, respectively) compared to lead-intoxicated rats without treatment. No significant change was observed in serum lead, ALP and ALT between artichoke and vitamin C-treated groups (p40.05). Furthermore, the liver histopathology in rats treated with artichoke showed a mild degree of lymphocyte infiltration that was relatively comparable to the control and vitamin C-treated groups. Discussion and conclusion: These results clearly show that the artichoke extract in lead-poisoned rats has suitable chelating properties for the reduction of blood lead levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Heidarian

Rafieian-Kopaei

2013

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…In previous studies administration of ascorbic acid decreased significantly but not completely Pb circulation in the blood. Some other studies in rats demonstrated that ascorbic acid decreased the intestinal absorption of lead [35] and increased the renal clearance of lead [36]. VC has also been reported to protect the cells and sperm from oxidative stress and loss of motility, respectively [37].…”

Section: Discussionmentioning

confidence: 99%

Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Ayinde

Ogunnowo

Ogedegbe

2012

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

BackgroundOccupational and environmental exposures to lead remain a public health problem as lead alters physiological processes by inducing oxidative stress and mimicking divalent cations. This study was designed to investigate the effects of Vitamin C (VC) and Vitamin E (VE) on the reproductive function of lead exposed male rats. Experimental animals were exposed to oral doses of lead, VC and VE at 60 mg/kg body weight, 40 mg/kg body weight, and 150 mg/kg body weight respectively, while control animals received 0.9% saline solution. Oral administration spanned for six weeks after which changes in testicular redox status, lead deposition, testicular zinc content, serum androgen content, semen quality and testis histology were examined.ResultsThere were significant (p < 0.05) increases in oxidative stress indices and testicular lead content. A significant (p < 0.05) depletion of zinc in the testis of lead exposed animals was also observed. Fluctuations were observed in androgen levels of lead treated animals with a significant increase (p < 0.05) in Serum follicle stimulating hormone (FSH) and testosterone (TT) content, while there was no significant change in luteinizing hormone (LH) content. Testicular tissue showed an alteration in its normal histology with degeneration of the seminiferous epithelium accompanied by a significant reduction (p < 0.05) in the number of luminal spermatozoa. A downgrade in the semen appearance and semen quality –sperm motility, morphology, and count was also observed after lead exposure. VC and VE treatment showed a significant (p < 0.05) reversal of the physiological alteration induced by lead.ConclusionsLead exposure resulted in a decline in the reproductive function of male rats by inducing oxidative stress, inhibiting enzymes and depleting testicular zinc contents. However, results clearly showed that VC and VE attenuated the deleterious impact of lead on the reproductive system.

show abstract

“…Elimination half-life of a drug is the key parameter which allows estimation of the time required for the drug to attain its steady state concentrations in the body. In general, steady state concentrations of a drug are attained in about 4 to 5 half-lifes, following its continuous administration (Rowland & Tozer 1980). In man, the elimination half-life of As-Ac ranges between 2 to 4 hr (Yung et al 1978).…”

Section: Discussionmentioning

confidence: 99%

“…L-Ascorbic acid (As-Ac) has been reported to alleviate cadmium toxicity in animals (Fox et al 1971) and it inhibits the bioavailability of dietary copper (Van Campen & Gross 1968). Another report by Niazi et al (1982) has suggested 120% increase in the urinary clearance of lead following the intravenous administration of lead along with As-Ac. Another report by Niazi et al (1982) has suggested 120% increase in the urinary clearance of lead following the intravenous administration of lead along with As-Ac.…”

mentioning

confidence: 99%

“…An epidemiological study by Needleman et al (1979) has suggested a correlation between low intake of vitamin C and incidence of lead poisoning. Another report by Niazi et al (1982) has suggested 120% increase in the urinary clearance of lead following the intravenous administration of lead along with As-Ac. This study also provided some evidence regarding the increase in the total amount of lead excreted in urine in one week following the use of As-Ac.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Interaction of L‐Ascorbic Acid on the Disposition of Lead in Rats

Dalley

Gupta

Lam

et al. 1989

Pharmacology & Toxicology

View full text Add to dashboard Cite

L-Ascorbic acid (As-Ac) has been investigated for its potential in the prophylaxis of lead poisoning. Using rats as the animal model, the pharmacokinetics of As-Ac was determined following a single intravenous dose (100 mg/kg) administered through a jugular vein. Plasma As-Ac levels were monitored using an enzyme assisted UV spectrophotometric method. The pharmacokinetic parameters of As-Ac obtained were used to establish a dosage regimen which could maintain its average plasma concentration of about 11 micrograms/ml at steady state in rats. The disposition of lead acetate (1 mg/kg) in rats was studied in the absence and presence of As-Ac at steady state. Lead concentrations were monitored in femur, kidney, liver and plasma over a 120 hr period using flameless atomic absorption spectrophotometry. In presence of As-Ac, femur, kidney and liver demonstrated 56, 22 and 41% respective reductions in their exposure towards lead. In addition, the half-life of lead in femur and plasma was found to be reduced by 27 and 51% respectively.

show abstract

Effect of Ascorbic Acid on Renal Excretion of Lead in the Rat

Cited by 9 publications

References 2 publications

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat

Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats

Interaction of L‐Ascorbic Acid on the Disposition of Lead in Rats

Contact Info

Product

Resources

About