Effect of Ascorbic Acid on Certain Blood Fat Metabolism Factors in Animals and Man

Sokoloff, Boris; Hori, Michiteru; Saelhof, Clarence C.; McConnell, Ben; Imai, Tomie

doi:10.1093/jn/91.1.107

Cited by 61 publications

(17 citation statements)

References 18 publications

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“…Willis [39] was able to produce lesions in guinea pig arteries which were morphologically similar with those in human athero sclerosis by feeding L-ascorbic acid-deficient diets. L-Ascorbic acid (150 mg/kg/day) greatly decreased the lesions of experimental rabbit cholesterol atherosclerosis when examined grossly after 8 months of treatment [35]. Yavorsky et at.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid and its 2-Sulfate on Rabbit Aortic Intimal Thickening

Verlangieri¹,

Hollis²,

Mumma³

1977

J Vasc Res

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Effects of intravenously injected L-ascorbic acid or L-ascorbic acid 2-sulfate on aortic intimal thickening were examined histologically, qualitatively, and quantitatively in the upper, middle and lower thoracic aortic positions of cholesterol-induced atherosclerotic rabbits. A means of evaluating the degree of pathology of the aortic positions was developed employing five descriptive statistics of intimal thickening. Both L-ascorbic acid and L-ascorbic acid 2-sulfate inhibited intimal thickening. The most significant reductions were observed in the upper thoracic aorta.

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Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid and its 2-Sulfate on Rabbit Aortic Intimal Thickening

Verlangieri¹,

Hollis²,

Mumma³

1977

J Vasc Res

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“…One of the presumed reasons for our negative results may be the relatively small dose and short-term treatment with vitamins. Rabbits fed cholesterol (100 mg/kg body weight/day) and ascorbic acid (150 mg/kg body weight/ day) for 8 months showed fewer pathologic vascular changes than the rabbits fed cholesterol alone [39]. Another rabbit study [40] showed that the protection by vitamin E (0.04 g/kg/day) was associated with a decrease in blood and aortic tissue malondialdehyde concentration in spite of hypercholesterolemia.…”

mentioning

confidence: 98%

Effects of Antioxidant Vitamins C and E on Atherosclerosis in Lipid-Fed Rabbits

Sun¹,

Zhu²,

Sievers³

et al. 1998

Cardiology

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Background: Antioxidant vitamins are hypothesized to help prevent atherosclerosis by blocking lipoprotein oxidation. We investigated the effects of dietary vitamins C and E on atherosclerosis in rabbits. Methods and Results: Forty New Zealand male rabbits were divided into 4 groups: 0.3% cholesterol diet with (LV) and without vitamin (LC), and 0.5% cholesterol diet with (HV) and without vitamins (HC). The treated groups consumed 137 ± 8 mg/day vitamin C and 80 ± 4 mg/day vitamin E for 10 weeks. Vitamin treatment did not significantly affect serum lipids. α-Tocopherol values were significantly higher in both serum (mg/dl) and omental fat (µg/g) among the treated rabbits (3.9 ± 0.5 and 31.6 ± 2.1 for LV, 1.7 ± 0.2 and 12.1 ± 1.9 for LC, 5.6 ± 0.8 and 51.3 ± 9.3 for HV and 1.9 ± 0.3 and 8.2 ± 0.4 for HC; p < 0.001). Vitamin treatment did not affect the percent of surface lesions in the aorta and pulmonary artery (23.8 ± 5.2 and 20.1 ± 3.3% for LV, 19.8 ± 5.6 and 23.2 ± 3.5% for LC, 28.1 ± 6.5 and 51.1 ± 4.2% for HV and 32.4 ± 5.5 and 43.7 ± 3.9% for HC, respectively; p = 0.981 and p = 0.562. Conclusions: Although significantly higher values of α-tocopherol were found in both serum and omental fat, antioxidant vitamins C and E did not demonstrate a significant protective effect on atherosclerosis in lipid-fed rabbits during the 10-week study period.

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“…In rats and rabbits fed cholesterol, Sokoloff et al [70] found a gradual decline in LPL activity, accompanied by an increase in TG levels. However, additional AA inhibited the reduction in LPL activity and the associated elevation of TG levels.…”

Section: Effect Of Aa On Lipid Metabolismmentioning

confidence: 98%

“…It has been proposed that the reduction of TG levels by AA may also be attributable to an effect on LPL [70]. In rats and rabbits fed cholesterol, Sokoloff et al [70] found a gradual decline in LPL activity, accompanied by an increase in TG levels.…”

Section: Effect Of Aa On Lipid Metabolismmentioning

confidence: 99%