Effect of aspirin on phase gradient of 2F1–F2 distortion product otoacoustic emissions

Parazzini, Marta; Hall, Amanda; Lutman, Mark E.; Kapadia, Sarosh

doi:10.1016/j.heares.2005.02.010

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…Aspirin reversibly reduces overall otoacoustic emission amplitudes . The evoked distortion products were reduced in amplitude and changed in fine structure . Similar effects have been observed for quinine as discussed above.…”

Section: Other Audiological Responses: Comparison Between Quinine Andsupporting

confidence: 74%

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Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

Alván

Berninger

Gustafsson

et al. 2016

Basic Clin Pharma Tox

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This review has the purpose to summarize concentration-effect studies made with quinine and to compare the effects on hearing between quinine and salicylate. Quinine and salicylate have roles in experimental hearing research and may induce pronounced and reversible hearing impairment when administered in sizeable doses. The quinine-induced increase in hearing threshold and its recovery can be analysed according to 'the psychophysical power function'. The power function is a special case of the Hill equation when the stimulus (e.g. a drug concentration) is exceedingly small compared with the concentration that would elicit a half-maximum response. Quinine and salicylate induce sensorineural hearing impairment and tinnitus when given in higher dose ranges in man. The drugs influence the presence, magnitude, and quality of audiological responses, such as spontaneous and evoked otoacoustic emissions. Quinine reversibly reduces frequency selectivity and hearing sensitivity, whereas the self-attained most comfortable speech level and the acoustic stapedius reflex are not affected, that is the dynamic range of hearing is reversibly reduced. This observation supports the view that quinine acts on the outer hair cell of the cochlea. Both drugs share a protective effect against the permanent hearing damages caused by gentamicin. This action is interpreted as a request for functioning mechanoelectric transducer (MET) channels to elicit the ill effect of aminoglycosides. Both drugs may interfere with the cochlear amplifier through blocking MET channels and the motor protein prestin. This review finds considerable overlap between type and extent of pharmacological actions of quinine and salicylate, supposedly caused by partly shared mechanisms of action but performed with different molecular mechanisms.The aim of this MiniReview was to explore key findings from the few concentration-effect (pharmacokinetic-pharmacodynamic, PK-PD) studies that have been performed with quinine, to understand the extent and mechanisms of reversibly impaired hearing. With respect to salicylate, concentration-effect studies are scarce. Considering the overlap of sensorineural effects of quinine and aspirin, we have compared studies on their respective mechanisms to interfere with hearing. Quinine has been used as a drug since the 17th century, in the beginning as bark from the cinchona tree. The most significant medical indication is severe malaria where it still has a role. It has been argued that the availability of quinine was a key factor in making Africa safe for non-immune Europeans as malaria was a deadly threat [1]. Quinine has been used to induce abortion and has killed many women because of its general toxicity. Both quinine and its isomer quinidine affect ion channels and cause life-threatening arrhythmia taken in overdose. Salicylate was known to the ancients and manufactured synthetically in the 19th century. Its neuropharmacological effects on hearing both peripherally and centrally have recently been updated [2].The heari...

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Section: Other Audiological Responses: Comparison Between Quinine Andsupporting

confidence: 74%

“…Further, spontaneous otoacoustic emissions were abolished after the intake of 16 doses of 325 mg aspirin every 6 hr [40]. Aspirin reversibly reduces overall otoacoustic emission amplitudes [41]. The evoked distortion products were reduced in amplitude [42] and changed in fine structure [41,43].…”

Section: Quininementioning

confidence: 97%

Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

Alván

Berninger

Gustafsson

et al. 2016

Basic Clin Pharma Tox

View full text Add to dashboard Cite

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“…Moreover, OAEs are a well-described method for detecting cochlear involvement by external agents. Low-level noise exposure ͑Skellett et al, 1996͒, increased body temperature due to fever ͑O'Brien, 1994͒, administration of salicylate ͑McFadden andPlattsmier, 1984;Janssen et al, 2000;Parazzini et al, 2005a͒, or Some authors studied the interaction between mobile phone radiation and the cochlear OHCs functionality by means of OAEs both in animals and humans, observing sometimes significant effects that might be attributable to exposure, but these results are inconsistent and need further confirmation. Marino et al ͑2000͒ found no statistically significant evidence measuring DPOAEs in Sprague-Dawley rats after chronic exposure to EMFs.…”

Section: Introductionmentioning

confidence: 99%

Effects of mobile phone exposure on time frequency fine structure of transiently evoked otoacoustic emissions

Paglialonga

Tognola

Parazzini

et al. 2007

The Journal of the Acoustical Society of America

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Mobile phones have become very commonly used worldwide within a short period of time. To date there is only limited knowledge about interaction between electromagnetic fields (EMFs) emitted by mobile phones and the auditory function. Moreover, there is widespread concern that there may be potential for harm. The aim of this study was to assess potential subtle changes in cochlear function by measuring the temporal and spectral fine structure of transiently evoked otoacoustic emissions (TEOAE) in normal hearing subjects after exposure to EMFs emitted by Global System for Mobile Communication (GSM) mobile phones. TEOAEs were recorded in 27 healthy young adults before and after 10 min of real or sham exposure in a double-blind design. TEOAE data were analyzed both globally (broadband analysis) and using the Wavelet Transform (analysis of the time-frequency fine structure). The broadband analysis revealed no significant effect on TEOAEs related to exposure, confirming results of previous studies; in addition, no significant change was detected in the analysis of the elementary wavelet components, suggesting that the temporal and spectral fine structure of TEOAEs is not affected by 10 min exposure to low-intensity EMFs emitted by GSM mobile phones.

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“…OAEs were recorded using non-standard equipment that allowed utilisation of the maximum length sequence (MLS) technique. That technique has been used previously in our studies of hearing monitoring techniques [24,50,58] and found to be more sensitive to small changes over time than conventional techniques. However, we also employed a conventional method using regular click stimuli and non-overlapping recording epochs, so that our results can be compared with other studies.…”

Section: Otoacoustic Emissionsmentioning

confidence: 99%

Periaural Music Player Daily Use Does Not Significantly Influence the Hearing Thresholds

Saralidze¹,

N²,

Tushishvili³

et al. 2019

Lʹviv. klin. visn.

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The Noise at Work Regulations 1989 and the Control of Noise at Work Regulations 2005 (the Regulations) are designed to minimise risk of occupational noise-induced hearing loss in the UK. The present study examined their effectiveness in a longitudinal field study, where participants were seen annually over a period of 3 years. Audiometric and otoacoustic emission measures were obtained in 154 recruits aged 18-25 years at risk of noise-induced hearing loss through occupational exposure and 99 non-exposed controls. The study had power to detect approximately 1-2 dB change per year, which is a smaller change than would be expected in the noise-exposed participants without protection. There were no significant effects on auditory function, or rate of change in function, of risk group when other potential explanatory variables were taken into account. Nor were there significant effects when contrasting exposed participants working in companies demonstrating relatively lower or higher compliance with the Regulations. Noise levels in exposed participants averaged approximately 88-89 dB(A) before accounting for hearing protection. The only significant effects on hearing demonstrated in the study were small effects of estimated social noise prior to the study, for example at nightclubs or from personal audio systems. Limitations of the study arise from the range of noise level encountered and the restricted duration of the study, which precludes showing longer-term effects. The companies involved in the study are not necessarily representative of the UK in terms of their compliance. Within these limitations, no evidence for lack of effectiveness of the Regulations was found. This report and the work it describes were funded by the Health and Safety Executive (HSE). Its contents, including any opinions and/or conclusions expressed, are those of the authors alone and do not necessarily reflect HSE policy. HSE Books

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Effect of aspirin on phase gradient of 2F1–F2 distortion product otoacoustic emissions

Cited by 11 publications

References 25 publications

Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

Concentration–Response Relationship of Hearing Impairment Caused by Quinine and Salicylate: Pharmacological Similarities but Different Molecular Mechanisms

Effects of mobile phone exposure on time frequency fine structure of transiently evoked otoacoustic emissions

Periaural Music Player Daily Use Does Not Significantly Influence the Hearing Thresholds

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