Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats

Augusti, Paula Rossini; Conterato, Greicy M. M.; Somacal, Sabrina; Sobieski, Rocheli; Spohr, P.R.; Torres, José V.; Charão, Mariele Feiffer; Moro, Ângela M.; Rocha, Marta Pires da; Garcia, Solange Cristina; Emanuelli, Tatiana

doi:10.1016/j.fct.2007.08.001

Cited by 66 publications

(46 citation statements)

References 47 publications

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“…Augusti et al, (2008) demonstrated the protective role of astaxanthin against mercury nephrotoxicity by reducing OS. A carotenoid, astaxanthin is able to prevent the increased LPO and protein oxidation and attenuate histopathological changes caused by mercuric chloride in kidney.…”

Section: Protective Effect Of Medicinal Plants-derived Antioxidants Imentioning

confidence: 99%

A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants

Palipoch

2013

Afr. J. Trad. Compl. Alt. Med.

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Acute kidney injury (AKI) is the common clinical syndrome which is associated with increased morbidity and mortality. The severity extends from less to more advanced spectrums which link to biological, physical and chemical agents. Oxidative stress (OS)-related AKI has demonstrated the increasing of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the decreasing of endogenous antioxidants. Medicinal plants-derived antioxidants can be ameliorated oxidative stress-related AKI through reduction of lipid peroxidation (LPO) and enhancement of activities and levels of endogenous antioxidants. Therefore, medicinal plants are good sources of exogenous antioxidants which might be considered the important remedies to ameliorate pathological alterations in oxidative stress-related AKI.

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Section: Protective Effect Of Medicinal Plants-derived Antioxidants Imentioning

confidence: 99%

A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants

Palipoch

2013

Afr. J. Trad. Compl. Alt. Med.

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“…Heo et al (2008) have reported the restorative and protective effects of fucoxanthin against H 2 O 2 induced oxidative stress and associated damage. Ax and fucoxanthin (and its metabolites including FuOH) are known to exert antioxidant effect by scavenging superoxide anion and reducing active intermediates as well as up-regulating the activity of antioxidant enzymes in addition to inhibiting molecules such as NF-κB, NO, COX-2 (Augusti et al 2008;Kim et al 2009, Peng et al 2011). …”

Section: Resultsmentioning

confidence: 99%

Does squalene alter the antioxidant potential of astaxanthin and fucoxanthinol? In vitro evidence in RAW 264.7 cells, a murine macrophage

et al. 2015

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Astaxanthin (Ax) and fucoxanthin/fucoxanthinol (FuOH) are marine xanthophylls exhibiting anti-oxidant effects. Squalene (SQ) is a triterpenoid and is a precursor of sterols. This study aimed to determine if SQ can improve the effect of Ax/FuOH on lipid peroxidation. RAW 264.7 cells were treated with different concentrations of Ax, FuOH and SQ and corresponding rate of cell survival was noted. In addition,combination groups -Ax + SQ and FuOH + SQ-were also run. Cells treated with Ax, FuOH, SQ, Ax + SQ and FuOH + SQ were stimulated with lipopolysaccharide and lipid hydroperoxides were estimated. Results showed that 5 μM Ax, 2 μM FuOH and 10 μM SQ supported cell survival. In presence of SQ, cell viability improved for higher concentrations of FuOH (5, 10 μM). Lipid hydroperoxides were supressed by Ax, FuOH, Ax + SQ and FUOH +SQ and were significantly lower in Ax + SQ, indicating the synergistic effect of Ax and SQ. To conclude, combination of Ax with SQ enhances its ability to supress lipid peroxidation while with FuOH, SQ attenuates the toxic effect at higher doses. Moreover, this is the first time that the combined effect of SQ and carotenoids has been studied and reported.

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“…Many studies have proven that astaxanthin has a preventive effect on various kidney diseases [1][2][3][4][5] . Oxidative stress and apoptosis are common pathophysiological features of contrast agent induced acute kidney injury (CI-AKI), hence ATX may have a potential therapeutic role in this condition.…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Astaxanthin on Contrast agent induced acute kidney injury

Li¹

2018

J Cardiol and Cardiovasc Sciences

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Contrast agent induced acute kidney injury (CI-AKI) is a leading cause of hospital-acquired acute kidney injury as a result of more and more iodinated contrast-media use for diagnostic purposes. Previous studies have demonstrated that oxidative stress and apoptosis are established processes contributing to contrast agent induced acute kidney injury. Astaxanthin (ATX), a carotenoid found in microalgae, fungi, complex plants, seafood, flamingos and quail has been confirmed have anti-oxidant, and anti-apoptosis effects. Experimental investigations in a range of species using a contrast agent induced acute kidney injury model demonstrated kidney preservation when ATX is administered prior to the induction of contrast agent. ATX, as an natural antioxidant, is capable to prevent CI-AKI effectively, and the mechanism is possibly related to anti-oxidant and anti-apoptosis. In this mini review, we briefly summarize the potential for ATX as a protector against CI-AKI pathologies.

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Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats

Cited by 66 publications

References 47 publications

A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants

A review of oxidative stress in acute kidney injury: protective role of medicinal plants-derived antioxidants

Does squalene alter the antioxidant potential of astaxanthin and fucoxanthinol? In vitro evidence in RAW 264.7 cells, a murine macrophage

Research Progress of Astaxanthin on Contrast agent induced acute kidney injury

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