Effect of astragaloside IV on hepatic glucose‐regulating enzymes in diabetic mice induced by a high‐fat diet and streptozotocin

Lv, Lin; Wu, Shaoyu; Wang, Guangfa; Zhang, Jiajie; Pang, Jinwei; Liu, Zhongqiu; Xu, Wei; Wu, Shaofang; Rao, Jinjun

doi:10.1002/ptr.2915

Cited by 76 publications

(48 citation statements)

References 31 publications

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“…antioxidation, [3][4][5] antivirus, 6,7) anti-apoptosis, 8,9) anti-hyperglycemic, 10,11) neuroprotection, 13) gastroprotection, 14) anti-chronicasthma, 15) and anti-lung-cancer. 16) One of AS-IV's targets is the cardiovascular system, and especially the heart.…”

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confidence: 99%

Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

Zhao

et al. 2013

Biological & Pharmaceutical Bulletin

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Astragaloside IV (AS-IV) is one of the main active constituents of Astragalus membranaceus, which has various actions on the cardiovascular system. However, its electrophysiological mechanisms are not clear. In the present study, we investigated the effects of AS-IV on action potentials and membrane currents using the whole-cell patch clamp technique in isolated guinea-pig ventricular myocytes. AS-IV prolonged the action potential duration (APD) at all three tested concentrations. The peak effect was achieved with 1×10 −6 m, at which concentration AS-IV significantly prolonged the APD at 95% repolarization from 313.1±38.9 to 785.3±83.7 ms. AS-IV at 1×10 −6 m also enhanced the inward rectifier K + currents (I K1 ) and inhibited the delayed rectifier K + currents (I K ). AS-IV (1×10 −6 m) strongly depressed the peak of voltage-dependent Ca 2+ channel current (I CaL ) from −607.3±37.5 to −321.1±38.3 pA. However, AS-IV was not found to affect the Na + currents. Taken together, AS-IV prolonged APD of guinea-pig ventricular myocytes, which might be explained by its inhibition of I K . AS-IV also influences Ca 2+ signaling through suppressing I CaL .

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confidence: 99%

Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

Zhao

et al. 2013

Biological & Pharmaceutical Bulletin

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“…This may be explained on the basis that astragaloside-IV has strong antioxidant ability (Gui et al, 2012). The lowering serum total cholesterol (TC) and triglycerides (TG) levels with astragaloside-IV were also reported in another study (Lv et al, 2010). Decrease in total protein level reflecting the liver and kidney injury caused by CCl 4 (Al-Yahya et al, 2013).…”

Section: Discussionmentioning

confidence: 71%

Isolation of Astragaloside-IV and Cyclocephaloside-I from Astragalus gummifera and Evaluation of Astragaloside-IV on CCl4 Induced Liver Damage in Rats

Ranganath

Balakrishna

Pramila

et al. 2014

Asian J. of Biological Sciences

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Two Cycloartane saponins, astragaloside-IV and cyclocephaloside-I, were isolated from the roots of Astragalus gummifera. Their structures were determined by utilizing 1D and 2D NMR experiments. Hepatoprotective effects of astragaloside-IV against carbon tetrachloride (CCl 4 ) induced nephrotoxicity and hepatotoxicity in rats was studied. The rats (200-230 g) of either sex were divided into 6 groups (6 rats each). Injection of a single dose of CCl 4 increases the level of serum AST, ALT, GGT, ALP and total bilirubin activities, decreases non-protein sulfhydryls (NP-SH) and total proteins (TPs), increases malondialdehyde (MDA) and produces changes in hepatic and nephritic tissue structure. Administration of doses of 25, 50 and 75 mg kgG 1 of astragaloside-IV reversed significantly (p<0.001) the liver diagnostic blood markers as well as stricture of nephrotoxicity and hepatotoxicity of the treated groups when compared to the control group. The present finding indicated that astragaloside-IV is an active hepatoprotective agent that restores the affected biochemical markers and nephritic and hepatic tissues.

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“…MPP + -induced neurodegeneration is specific to dopamine neurons and can be prevented by drug treatment with ginsenoside Rg1 or astragaloside IV (38,39). Recent studies have demonstrated that certain botanical extracts have an antioxidant effects against oxidative-stress induced damage and PD (38,40). Standardized extracts of ginsenoside Rg1 can efficiently terminate the toxic effects of MPTP in PD animal models (38).…”

Section: Discussionmentioning

confidence: 99%

Astragaloside IV rescues MPP+-induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Effect of astragaloside IV on hepatic glucose‐regulating enzymes in diabetic mice induced by a high‐fat diet and streptozotocin

Abstract: Astragaloside IV exhibited a hypoglycemic effect in diabetic mice. The hypoglycemic effect of this compound may be explained, in part, by its inhibition of hepatic GP and G6Pase activities.

Cited by 76 publications

References 31 publications

Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

Isolation of Astragaloside-IV and Cyclocephaloside-I from Astragalus gummifera and Evaluation of Astragaloside-IV on CCl4 Induced Liver Damage in Rats

Astragaloside IV rescues MPP+-induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A

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