Effect of Astragalus injection on inflammatory mediators in patients with viral myocarditis: A systematic review and meta-analysis

Guo, Jing; Zhao, Ning; Jin, Peipei; Yin, Yuehui

doi:10.1016/j.phymed.2022.154436

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…The primary chemical components of A. mongholics are polysaccharides, saponins, and avonoids, and more than 200 compounds have been isolated from Astragalus membranaceus (Dong et al, 2023). Astragalus injection is clinically used to treat viral myocarditis (Guo et al, 2022), and astragalus polysaccharide can be used to treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) infection (Yeh et al, 2021). There have been several reports on the analysis of the GRF gene family; however, A. mongholics has not yet been studied (Lee et al, 2018)..…”

Section: Introductionmentioning

confidence: 99%

Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

Wang,

Cao

et al. 2024

Preprint

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Background Astragalus membranaceus is a plant of the Astragalus genus, which is used as a traditional Chinese herbal medicine with extremely high medicinal and edible value.Astragalus mongholics, as one of the representative medicinal materials with the same origin of medicine and food, has a rising market demand for its raw materials, but the quality is different in different production areas. Growth-regulating factors are transcription factors unique to plants that play important roles in plant growth and development. Up to now, there is no report about GRF in A. mongholics. Methods and results This study conducted a genome-wide analysis of the AmGRF gene family, identifying a total of nine AmGRF genes that were classified into subfamily V based on phylogenetic relationships. In the promoter region of the AmGRF gene, we successfully predicted cis-elements that respond to abiotic stress, growth, development, and hormone production in plants. Based on transcriptomic data and real-time quantitative polymerase chain reaction (qPCR) validation, the results showed that AmGRFs were expressed in the roots, stems, and leaves, with overall higher expression in leaves, higher expression ofAmGRF1 and AmGRF8 in roots, and high expression levels of AmGRF1and AmGRF9 in stems. Conclusions The results of this study provide a theoretical basis for the further exploration of the functions of AmGRFsin plant growth and development.

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Section: Introductionmentioning

confidence: 99%

Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

Wang,

Cao

et al. 2024

Preprint

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“…Bge. (Fabaceae) is a valuable herb in traditional Chinese medicine and has many pharmacological effects, such as enhancing immune function, inhibiting the in ammatory response, antiviral effects [5], and inducing tumor cell apoptosis [6]. Astragalus injection is one of the early varieties of injections that have been successfully developed and is widely used in clinics in China.…”

Section: Introductionmentioning

confidence: 99%

Astragalus injection alters the pharmacokinetics of doxorubicin and affects the activity of CYP450 enzymes

Shi

Tian

et al. 2023

Preprint

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Background Doxorubicin (DOX) is an antitumor antibiotic widely used in the treatment of breast cancer, liver cancer, lymphoma and other malignant tumors. However, its clinical application is limited by the side effects and drug resistance. Astragalus injection has been combined with DOX in the treatment of cancer, which can improve the curative effect and reduce drug resistance. This study investigated the interaction between DOX and Astragalus injection and elucidated the potential mechanism. Methods The pharmacokinetics of DOX injection (7 mg/kg) with or without Astragalus injection (4.25 mL/kg/day for 14 days) were investigated in male Sprague-Dawley rats (n = 6) by UPLC-MS/MS. The group without the Astragalus injection was set as the control group. Additionally, Sprague-Dawley rat liver microsomes incubation systems were employed to assess the effects of Astragalus injection on CYP450 enzymes. Results Astragalus injection significantly increased the Cmax (2090.01 ± 99.60 vs. 5262.77 ± 111.15 ng/mL) and AUC0-t (1190.23 ± 104.43 vs. 3777.27 ± 130.55 µg/L × h) and prolonged the t1/2α (0.09 ± 0.02 vs. 0.14 ± 0.04 h) of DOX. Astragalus injection significantly inhibited the activity of CYP1A2, CYP2C9, CYP2E1, and CYP3A4, and enhanced the activity of CYP2D1 with a metabolic elimination rate of 30.11 ± 2.67% vs 19.66 ± 3.41%, 35.95 ± 2.57% vs 23.26 ± 3.57%, 13.43 ± 2.56% vs 9.06 ± 2.51%, 47.90 ± 6.30% vs 25.87 ± 2.55%, 17.62 ± 1.49% vs 24.12 ± 2.91%, respectively (p < 0.05). Conclusions The co-administration of DOX and Astragalus injection alters the system exposure of DOX, possibly by affecting the metabolism of DOX by affecting the activity of CYP450 enzymes. Further clinical studies could be carried out according to the investigation.

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Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

Wang,

Cao

et al. 2024

Mol Biol Rep

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Effect of Astragalus injection on inflammatory mediators in patients with viral myocarditis: A systematic review and meta-analysis

Cited by 6 publications

References 29 publications

Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

Astragalus injection alters the pharmacokinetics of doxorubicin and affects the activity of CYP450 enzymes

Genome-wide identification and expression pattern analysis of the GRF transcription factor family in Astragalus mongholicus

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