Effect of AT1 angiotensin receptor antagonist on lipid peroxidation and antioxidative defense in diabetic kidney

Kędziora–Kornatowska, Kornelia; Luciak, M; Błaszczyk, Jan; Pawlak, Wojciech; Kędziora, J

doi:10.1016/s0928-4680(99)00028-0

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Thus, it is well known that mechanisms that increase levels of blood glucose produce kidney disease, including nonenzymatic glycosylation of proteins, an increase in oxidative stress, alteration in protein kinase C isoforms, and nephropathy [30]. Furthermore, enhanced oxidative stress due to diabetes may also result from a dysfunction in the defense system against free radicals, such as reduction of GSH, GSH-Px, SOD and CAT, vitamin A, and beta carotene [1].…”

Section: Discussionmentioning

confidence: 99%

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Ulaş

Çay

2011

Biol Trace Elem Res

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The aim of this study was to investigate the effects of vitamin E (alpha-tocopherol) and 17β-estradiol (E(2)) supplementation on malondialdehyde (MDA), glutathione (GSH), vitamin A, beta carotene, selenium-dependent glutathione peroxidase (GSH-Px), zinc-dependent superoxide dismutase (SOD), and copper/zinc-dependent catalase (CAT) values in the kidney of ovariectomized (OVX) diabetic rats. Forty-two female rats were randomly divided into seven equal groups as follows: group I, control; group II, OVX; group III, OVX+E(2); group IV, OVX+E(2)+alpha-tocopherol; group V, OVX+diabetic; group VI, OVX+diabetic+E(2); and group VII, OVX+diabetic+E(2)+alpha-tocopherol. E(2) (40 μg kg(-1)/day) and alpha-tocopherol (100 μg kg(-1)/day) were given. Bilateral ovariectomy was performed in all groups except group I. After 4 weeks, antioxidant and MDA levels in the kidney for all groups were analyzed. GSH-Px, CAT, SOD, GSH levels, vitamin A, and beta carotene levels were decreased in OVX group compared to those in the control group but MDA level was elevated via ovariectomy. However, E(2) and E(2)+alpha-tocopherol supplementations in OVX group was associated with an increase in the GSH-Px, GSH, CAT and Zn-SOD values, vitamin A, and beta carotene levels but a decrease in MDA levels in kidney. The MDA levels in the kidney of diabetic OVX rats were found higher than those in the control and OVX groups. However, GSH, GSH-Px, CAT, SOD, vitamin A, and beta carotene levels in kidney were lower in OVX diabetic rats. On the other hand, E(2) and E(2)+alpha-tocopherol supplementations to OVX diabetic rats have caused an increase in GSH-Px, CAT and SOD, GSH, vitamin A, and beta carotene levels but a decrease in MDA levels. In conclusion, the E(2) and E(2)+alpha-tocopherol supplementations to diabetic OVX and OVX rats may strengthen the antioxidant defense system by reducing lipid peroxidation, and therefore they may play a role in preventing renal disorders.

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Section: Discussionmentioning

confidence: 99%

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Ulaş

Çay

2011

Biol Trace Elem Res

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“…On the other hand Kedziora-Kornatowska et al (17) showed significant increase in supraoxide anion generation in patients treated with cimetidine vs those treated with famotidine and ranitidine. All three drugs stimulated superoxide dismutase activity and decreased malondialdehyde concentration.…”

Section: Acta Physiologica Hungarica 90 2003mentioning

confidence: 95%

Activity of cathepsin B, D and L in rat cerebrum after cimetidine and famotidine administration

Burdan

Madej²,

Radzikowska³

et al. 2003

Acta Physiologica Hungarica

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Cathepsins are lysosomal enzymes that are used a sensitive markers in various toxicological investigations. The purpose of this study was to evaluate and compare the influence of cimetidine and famotidine on the cerebral cortex, particularly on the activity of cortical cathepsin B, D and L in the frontal lobe of rat brain. The drugs were administered intraperitoneally, twice a day, for six weeks to male Wistar rats in two doses. The initial dose was 2.85 mg/kg for cimetidine and 0.285 mg/kg for famotidine. The second dose was 10 times higher. Control animals were injected with 0.9% NaCl. Half of the animals from each of the drug-treated and control groups were sacrificed on the 42nd day of the experiment. The remaining animals were raised for another 6 weeks without any xenobiotics, and sacrificed on the 84th day. The frontal lobe of the right cerebral hemisphere was taken for biochemical investigation. The activities of free and bound fractions of cathepsin B, D and L were evaluated spectrophotometrically in cortical homogenates. The activity of bound fraction of cathepsin D and L decreased significantly in animals exposed to the higher dose of cimetidine and sacrificed on the 42nd day. Also significant elevation of the free fraction of cathepsin L was noted in the same group of rats. Cathepsin activities were normalized during the next six weeks. No behavioural changes were noted among the observed animals. Unlike cimetidine, famotidine did not change profiles of the cerebral cathepsins.

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Effect of AT1 angiotensin receptor antagonist on lipid peroxidation and antioxidative defense in diabetic kidney

Cited by 2 publications

References 26 publications

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

17β-Estradiol and Vitamin E Modulates Oxidative Stress-Induced Kidney Toxicity in Diabetic Ovariectomized Rat

Activity of cathepsin B, D and L in rat cerebrum after cimetidine and famotidine administration

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