Effect of Atorvastatin on Activities of Matrix Metalloproteinases and Chitotriosidase in Male and Female Mice with Experimental Hyperlipidemia

Abstract

Activities of matrix metalloproteinases and chitotriosidase were measured in blood serum from male and female ICR mice with moderate hyperlipidemia receiving atorvastatin (75 mg/kg). Hyperlipidemia in male and female mice was characterized by increased serum concentration of cholesterol and, especially, triglycerides. The observed changes were more pronounced in female mice. Administration of atorvastatin decreased cholesterol (but not triglyceride) level in intact males, but had no effect on these parameters in females; chitotriosidase activity increased in male and female mice, while activity of matrix metalloproteinases increased only in males. Administration of atorvastatin produced similar effects in male and female mice with moderate hyperlipidemia: decrease in the concentration of cholesterol and, particularly, of triglycerides. Activities of matrix metalloproteinases and chitotriosidase increased in males and females, this increase being more pronounced in males. The existence of a negative correlation between cholesterol and triglyceride concentrations and activities of matrix metalloproteinases and chitotriosidase in males suggests that these enzymes can serve as a therapeutic target during hyperlipidemia.

Identification of a Chromosome 1 Substitution Line B6-Chr1BLD as a Novel Hyperlipidemia Model via Phenotyping Screening

“…Furthermore, many clinical data have also proved that the level of lipid metabolism is different between male and female patients with hyperlipidemia [98,99]. And hyperlipidemia-related drugs have different effects on male and female patients and animal models [100,101]. Based on the clinical differences between male and female hyperlipidemia patients, we need to construct appropriate female or male hyperlipidemia mouse models separately for the study of the disease.…”